Ergen K, Yildiz F, Ozcan M, Cekmen M, Tanyeri P -, Utkan T -, Karakoc Y

Effects of Cigarette Smoke on Tissue Trace Element Concentration of Rats Exposed to Second-hand Smoke

Trace elements have an important effect on and play a key role in a variety of the processes necessary for life. Studies have indicated a definite correlation between content of trace elements and many common diseases. It has been concluded that smoking may be a substantial source of intake of these hazardous elements, not only to the smoker, but to nonsmokers via passive smoke, as well. Even passive intake of such elements can change the metabolism of other trace elements and influence their concentrations. In order to assess their potential role in some human diseases, it is necessary to measure trace element concentrations in various tissues in experimental models. In this study, liver, kidney and spleen tissue samples from rats exposed to secondhand smoke were analysed for Fe, Cu, Zn, Cr, Mn and Co trace element levels by atomic absorption spectrophotometer. Cr, Mn, Fe and Co levels in the liver, Fe and Co levels in the kidney, and Zn, Cu, Mn and Co levels in the spleen were significantly lower than those of controls, but Cu levels in the kidney and Fe levels in the spleen were significantly higher than those of controls. Our data suggest that chronic exposure to cigarette smoke alters the trace element concentration of various tissues in rats exposed to secondhand smoke. These alterations may be attributable to oxidative stress produced by cumulative effect of inhaled smoke rather than the toxic effect of absorbed toxic metals. Low Mn levels in the liver and spleen, increased Cu levels in kidney and Fe levels in the spleen, and changes in the metabolism of Zn, Fe and Cu may be indicators of oxidative stress. Decreases in Coand Cr levels in rats exposed to secondhand smoke may also be related to the intake of the toxic trace elements present in cigarette smoke.

Anahtar Kelimeler:

toxic elements, trace elements, cigarette smoke, oxygen free radical, oxidative stress

Effects of Cigarette Smoke on Tissue Trace Element Concentration of Rats Exposed to Second-hand Smoke

Keywords:

toxic elements, trace elements, cigarette smoke, oxygen free radical, oxidative stress,

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Cummings, N. Trace metals in the brain and Wilson’s disease. J Clin Path. 1968:21:1-7.
Ehmann WD, Markesbery W., Alauddin M, Hossain TIM, Brubaker EH. Brain trace elements in Alzheimer’s disease. Neurotoxicology. 1986;7:197-206.
Farkas E, Scheibler H, Reffy A. Bezur L. Al, Zn, Cu, Mn and Fe levels in brain in Alzheimer’s disease. Arch Gerontol Geriatr. 1995;21:89-97.
Reddy SB, Charles MJ, Raju GJ, Reddy BS, Reddy TS, Lakshmi PV, Vijayan V. Trace elemental analysis of cancer-afflicted intestine by PIXE technique. Biol Trace Elem Res. 2004;102(1-3):265-82.
Silvera SA, Rohan TE. Trace elements and cancer risk: a review of the epidemiologic evidence. Cancer Causes Control. 2007;18(1):7-27.
Sivulka DJ. Assessment of respiratory carcinogenicity associated with exposure to metallic nickel: a review. Regul Toxicol Pharmacol. 2005;43(2):117-33.
Adonis M, Martinez V, Marin P, Berrios D, Gil L. Smoking habit and genetic factors associated with lung cancer in a population highly exposed to arsenic. Toxicol Lett. 2005;159(1):32-7.
Goyer RA, Liu J, Waalkes MP. Cadmium and cancer of prostate and testis. Biometals. 2004;17(5):555-8.
Garg AN, Singh V, Weginwar RG, Sagdeo VN. An elemental correlation study in cancerous and normal breast tissue with successive clinical stages by neutron activation analysis. Biol Trace Elem Res. 1994;46(3):185-202.
Staerk, H. Comparative study of food and environmental contamination. IAEA Tech. Rep. STI/PUB. 1974;348-417.
Iskander FY. Cigarette ash as a possible source of environmental contamination. Environ Pollut B. 1986;11:291-301.
Chang MJ, Naworal JD, Walker K, Connell CT. Investigating on the direct introduction of cigarette smoke for trace element analysis by inductively coupled plasma mass spectrometry. Spectrochim Acta B. 2003;58(11):1979-1996.
Schwerha JJ. Occupational medicine forum. J Occup Environ Med. 2006;48(9):988-990.
Chiba M, Masironi R. Toxic and trace elements in tobacco and tobacco smoke. Bull World Health Organ. 1992;70(2):269-275.
Ernst, J.A. & Neal, P.R. Minerals and trace elements. In: R.A. Polin & W.W. Fox, (Eds.), Fetal and neonatal physiology. Philadelphia: W.B. Saunders Co. 1992:239-247.
Xie Y, Garban H, Ng C, Rajfer J, Gonzalez-Cadavid NF. Effect of long-term passive smoking on erectile function and penile nitric oxide synthase in the rat. J Urol. 1997;157(3):1121-1126.
Karakoc Y, Yurdakos E, Gulyasar T, Mengi M, Barutcu UB. Experimental stress-induced changes in trace element levels of various tissues in rats. J Trace Elem Exp Med. 2003;16(1):55-60.
Brys M, Nawrocka AD, Miekos E, Zydek C, Fonksizki M, Barecki A, Krajewska WM. Zinc and cadmium analyses in human prostate neoplasm. Biol Trace Elem Res. 1997;59:145-152.
Tokman N, Akman S, Ozcan M. Solid-phase extraction of bismuth, lead and nickel from seawater using silica gel modified with 3-aminopropyltriethoxysilane filled in a syringe prior to their determination by graphite furnace atomic absorption spectrometry. Talanta. 2003;59:201-205.
Prasad AS. Trace elements and iron in human metabolism. New York: John Wiley & Sons, Ltd. 1978;288.
Marlowe M, Cossairt A, Moon C, Errerg J, MacNeel A, Peak R, Jay R, Schroeder C. Main and interaction effect of metallic toxins on classroom behaviour. J Abnorm Child Psychol. 1985;13:185-198.
Nowak B, Chmielnicka J. Relationship of lead and cadmium to elements in hair, teeth, and nails of environmentally exposed people. Ecotoxicol Environ Saf. 2000;46:265-274.
Prasad AS. Trace elements and iron in human metabolism. New York: John Wiley & Sons Ltd. 1978;84-85.
Nandi M, Slone D, Jick H, Shapiro S, Lewis GP. Cadmium content of cigarettes. Lancet. 1969;2:1329-1330.
Menden EE, Elia VJ, Michael LW, Petering HG. Distribution of cadmium and nickel of tobacco during cigarette smoking. Environ Sci Technol. 1972;6:830.
Ostergaard K. The concentration of cadmium in renal tissue from smokers and non- smokers. Acta Med Scand. 1977;202:193-195.
Benes, B., Spevackova, V., Smid, J., Cejchanova, M., Cerna, M., Subrt, P. & Marecek, J. The concentration levels of Cd, Pb, Hg, Cu, Zn and Se in blood of the population in the Czech Republic. Cent Eur J Public Health. 2000;8:117-119.
Pannett B, Coggon D, Acheson E. A job-exposure matrix for use in population based studies in England and Wales. B J Industr Med.1985;42:777-783.
Skoczynska A, Smolik R, Milian A. The effect of combined exposure to lead and cadmium on the concentration of zinc and copper in rat tissues. Int J Occup Med Environ Health. 1994;7:41-49.
Osman K, Schutz A, Akesson B, Maciag A, Vahter M. Interactions between and toxic elements in lead exposed children in Katowice, Poland. Clin Biochem. 1998;31:657-665.
Tallkvist J, Bowlus CL, Lonnerdal B. DMT1 gene expression and cadmiumabsorption in human absorptive enterocytes. Toxicol Lett. 2001;122:171-177.
Zoller H, Koch RO, Theurl I, Obrist P, Pietrangeelo AS, Montosi G, Haile DG, Vogel W, Weiss G. Expression of the duodenal iron transporters divalent-metal transporter 1 and ferroprotein 1 in iron deficiency and iron overload. Gastroenterol. 2001;120:1412-1419.
Bensryd I, Rylander L, Högstedt B, Aprea P, Bratt I, Fåhraéus A, Holmén A, Karlsson A, Nilsson A, Svensson BG, Schütz A, Thomassen Y, Skerfving S. Effect of acid precipitation on retention and excretion of elements in man. Sci Total Environ. 1994;145(1-2):81-102.
Finley JW, Monroe P. Mn Absorption. The use of CACO-2 cells as a model of the intestinal epithelia. Nutr Biochem. 1997;8:92-101.
Bernhard D, Rossmann A, Wick G. Metals in cigarette smoke. IUBMB Life. 2005; 57(12):805-809.
Bashar SK, Mitra AK. Effect of smoking on vitamin A, vitamin E, and other trace elements in patients with cardiovascular disease in Bangladesh: a cross-sectional study. Nutr J. 2004;3:18.
Pucheau S, Coudray C, Tresallet N, Favier A, de Leiris J. Effect of dietary antioxidant trace element supply on cardiac tolerance to ischmia—reperfusion in the rat. J Mol Cell Cardio.1995;27(10):2303-2314.
Grandjean P, Nielsen GD, Jİrgensen PJ, Hİrder M. Reference intervals for trace elements in blood: significance of risk factors. Scand J Clin Lab Invest.1992;52:321-337.
Bremner I, Beattie JH. Copper and zinc metabolism in health and disease: speciation and interactions. Proc Nutr Soc.1995;54:489-499.
Grant ECG. Allergies Smoking and the Contraceptive Pill. In: G. Hemmings (Ed.), Biological Aspects of Schizophrenia and Addiction. Chichester: John Wiley & Sons Ltd. 1982;263-272.
Moynihan EJ. Trace elements in man. Philos Trans R Soc Lond B Biol Sci. 1979;288:65.
Davidoff GN, Votaw ML, Coon WW, Hultquist FA, Fitler EE, Wexler BJ. Elevations in serum copper, erythrocyte copper and ceruloplasmin concentrations in smokers. Am J Clin Path.1978;75:790.
Dubick MA, Keen CL. Influence of nicotine on tissue trace element concentrations and tissue antioxidant defense. Biol Trace Elem Res.1991;31(2):97-109.
Carrico RJ, Deutsch HF. The presence of zinc in human cytocuprein and some properties of the apoprotein. J Biol Chem. 1970;245:723-727.
Nordberg M, Nordberg GF. Toxicological aspects of metallothionein. Cell Mol Biol. 2000;46:451-463.
Suzuki K. Origin of senescence: a review. Horm. Res. 1993;39(Suppl 1):5-8.
Stohs SJ, Bagchi D. Oxidative mechanism in the toxicity of metal ions. Free Radic Biol Med. 1995;18:321-336.
Kulikowska-Karpinska E, Moniuszko-Jakoniuk J. Lead and zinc influence on antioxidant enzyme activity and malondialdehyde concentration. Pol J Environ Stud. 2001;10:161- 165.
Jurczuk M, Brzóska MM, Moniuszko-Jakoniuk J, Galażyn-Sidorczuk M, Kulikowska- Karpińska E. Antioxidant enzymes activity and lipid peroxidation in liver and kidney of rats exposed to cadmium and ethanol. Food Chem Toxicol. 2004:42(3):429-438.
Wolfsperger M, HauserG, Gossler W, SchlagenhaufenC. Heavy metals in human hair samples from Austria and Italy: influence of sex and smoking habits. Sci Total Environ. 1994:156(3):235-242.