Essam AL-DRABAH, Yacoub IRSHAİD, Nada YASEİN, Suheil ZMEİLİ

Prescription pattern of antihypertensive drugs in Family Practice Clinics at Jordan University Hospital

The present study represents the current prescribing trend for antihypertensive drugs in family medicine clinics at Jordan University Hospital in Jordan. The study sample involved 416 male and female hypertensive Jordanian patients. Our results demonstrate that 2 hypertensive patients were not receiving any antihypertensive therapy at the time of evaluation, 192 patients were on a single antihypertensive therapy, 157 patients were on two antihypertensive drugs, 52 patients were on triple antihypertensive therapy and 13 patients were on four or more drugs. The most frequent classes of antihypertensive drugs used or prescribed to patients either as a single therapy or in combinations include angiotensin converting enzyme inhibitors, Î²-blockers, calcium channel blockers, diuretics and angiotensin receptor blockers. Among the mono-therapy prescriptions, angiotensin converting enzyme inhibitors were the most commonly prescribed and diuretics were least used. In combined therapy, diuretics were the most prescribed antihypertensive drugs, followed by Î²-blockers. Combinations consisting of diuretics and Î²-blockers were the most commonly seen. With respect to overall use, angiotensin converting enzyme inhibitors were the most prescribed agents. Despite an observed significant reduction in blood pressure between first and last visits to the family clinics, most of the patients did not achieve recommended blood pressure control according to the international guidelines.

Anahtar Kelimeler:

Misoprostol; Amniotic fluid; Serum; Cervical ripening

Prescription pattern of antihypertensive drugs in Family Practice Clinics at Jordan University Hospital

Keywords:

Misoprostol; Amniotic fluid; Serum; Cervical ripening,

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Al-Safi SA, Aboul-Enein FH, Aboul-Enein BH. Influence of family history and lifestyle on blood pressure and heart rate in young adults in Jordan. Public Health. 2006;120:1027- 32.
Kearney PM, Whelton M., Reynolds K, Muntner P, Whelton PK, He J. Global burden of hypertension: analysis of worldwide data. Lancet. 2005;365:217-23.
Brown DW, Mokdad AH, Walke H, As'ad M, Al-Nsour M, Zindah M, Arqoob K, Belbeisi A. Projected Burden of Chronic, Noncommunicable Diseases in Jordan. Prev Chronic http://www.cdc.gov/pcd/issues/2009/apr/08_0162.htm. 2009;6:A78. Published online 2009 March15
The world health report Reducing Risks, Promoting Healthy Life. 2002; http://www.who.int/whr/2002.
Weinberger MH. Seminars in Cerebrovascular Diseases and Stroke. 2003;3:3237-41.
European Society of Hypertension and European Society of Cardiology Guidelines Committee. 2003 European Society of Hypertension – European Society of Cardiology guidelines for management of arterial hypertension. J Hypertens. 2003;21:1011-53.
Jaddou HY, Bateiha AM, Al-Khateeb MS, Ajlouni KM. Epidemiology and management of hypertension among Bedouins in Northern Jordan. Saudi Med J. 2003;24:472-76.
Jaddou HY, Bateiha AM, Ajlouni KM. Prevalence, awareness and management of hypertension in a recently urbanized community, eastern Jordan. J Hum Hypertens. 2000;14:497-501.
Dipiro JT, Talbert RL, Yee GC, Matzke GR, Wells BG, Posey LM. Pharmacotherapy a pathological approach. 7th ed. McGraw-Hill Companies Inc, New York, 2008:139-72.
Pocok SJ, McCormack V, Gueyffier F, Boutite F, Fagard RH, Boissel JP. A score for predicting risk of death from cardiovascular disease in adults with raised blood pressure, based on individual patients data from randomized controlled trials. BMJ. 2001;323:75- 81.
Staessen JA, Sowski JG, Wang JG. Treatment of isolated systolic hypertension in the elderly: evidence from three clinical trials. Eur J Intern Med. 1999;10:82-7.
Appel LJ, Moore TJ, Obarzanek E, Vollmer WM, Svetkey LP, Sacks FM, BrayGA, Vogt TM, Cutler JA, Windhauser MM, Lin PH, Karanja N. "A Clinical Trial of the Effects of Dietary Patterns on Blood Pressure". NEJM. 1997;336:1117-24.
Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL, Jones DW, Materson BJ, Oparil S, Wright JT Jr., Roccella EJ. Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension. 2003;42:1206-52.
Babaei H. Antihypertensive Drugs. A book published by InTech Janeza Trdine 9, 51000 Rijeka, Croatia, 2012.
Al-Azzam SI, Najjar RB, Khader YS. Awareness of physicians in Jordan about the treatment of high blood pressure according to the seventh report of the Joint National Committee (JNC VII). Eur J Cardiovasc Nurs. 2007;6:223-32.
Nelson M. Drug treatment of elevated blood pressure. Aust Prescr. 2010;33:108-12.
Jaddou HY, Bateiha AM, Ajlouni KM. Prevalence and associated factors of hypertension: results from three community based survey, Jordan. J Hum Hypertens. 1996;10:815-21.
Al- Mehza AM, Al-Yahya AA, Al-Qattan MM, Al-Duwaisan HS, Al-Otaibi DNMB. Determinants of Poor Blood Pressure Control in Hypertensive Patients An Area-based Study. KMJ. 2004;36:270-4.
Al Khaja JKA, Sequeira RB, Abdul Wahab AWM, Mathur VS. Antihypertensive drug prescription trends at the primary health care centers. Pharmacoepidimilogy and Drug Safety. 2001;10:219-27.
Sweileh W. Pharmacotherapeutic Analysis and Prescription Pattern of Antihypertensive Drugs Dispensed at Community Pharmacies in Palestine. An-Najah Univ J Res (N. Sc). 2003;17:167-81.
Chamontin B, Poggi L, Lang T, LangT, LangT, MénardJ, ChevalierH, Gallois H, CrémierO. Prevalence, treatment, and control of hypertension in the French population: data from a survey on high blood pressure in general practice, 1994. Am J Hypertens. 1998;11:759-62.
Sturani A, Esposti ED, Serra M, Ruffo P, Valpiani G. Assessment of antihypertensive drug use in primary care in Ravenna, Italy, based on data collected in the PANDORA project. Clin Ther. 2002;24:249-59.
Youssef RM, Moubarak II. Patterns and determinants of treatment compliance among hypertensive patients. East Mediterr Health J. 2002;8:579-92.
Walley T, Duggan AK, Haycox AR, Niziol CJ. Treatment for newly diagnosed hypertension: patterns of prescribing and antihypertensive effectiveness in the UK. J R Soc Med. 2003;96:525-31.
Ma J, Lee KV, Stafford RS. Changes in antihypertensive prescribing during US outpatient visits for uncomplicated hypertension between 1993 and 2004. Hypertension 2006;48:846-52.
Amar J, Vaur L, Perret M, Bailleau C, Etienne S, Chamontin B; PRATIK study investigators. Hypertension in high-risk patients: beware of the underuse of effective combination therapy (results of the PRATIK study). J Hypertens. 2002;20:779-84.
Stergiou GS, Karotsis AK, Symeonidis A, Vassilopoulou VA. For the ABC–GP Study Group. Aggressive blood pressure Control in General Practice (ABC–GP) study: can the new targets be reached? J Hum Hypertens. 2003;17:767-73.
Mubarak FM, Froelicher ES, Jaddou HY, Ajlounia KM. Hypertension among 1000 patients with type 2 diabetes attending a national diabetes center in Jordan. Ann Saudi Med. 2008;28:346-51.