Possibility of reinnervation and prevention of distal target organ atrophy following side to side neurorrhaphy to the intact nerve after end to end repair of proximal transected peripheral nerves

The aim of the study is to investigate the possibility of reinnervation and prevention of muscle atrophy following side to side neurorrhaphy to the intact nerve after end to end repair of proximal transected peripheral nerves in order to prevent distal target organ atrophy. For this, four groups each containing five Sprague–Dawley female rats were used. In group I, no surgical procedure was performed as a control group. In group II, side to side distal neurorrhaphy performed to the tibial and peroneal nerves after end to end repair of transected proximal tibial nerve. In group III. distally side to side epineural neurorrhaphy performed to the tibial and peroneal nerves. In group IV, end to end epineural repair was performed after proximal tibial nerve transection. The rats were followed up for 3 months for nerve regeneration. Subsequently group II, III and IV were evaluated histopathologically. In all group, tibial and fibular bony weights, foot weights, anterior and posterior crural muscle weights and EMG parameters were evaluated. Comparison between the groups revealed no significant differences regarding EMG and muscle weights between groups 2 and 4 also axonal degeneration was observed in 3 group after neurorrhaphy. As result of experimental study, we think that side to side repair of intact distal nerves as an adjunct to end to end repair of proximal nerve transections has no additional benefit to prevent distal organ atrophy but rather may be caused harm on the intact nerve. In addition, it has been observed that this technique affects the intact nerve rather than the transected nerve.

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Brushart TM, Tarlov EC, Mesulam MM. Specificity of muscle reinnervation after epineurial and individual fascicular suture of the rat sciatic nerve. J Hand Surg Am. 1983;8:248-53.

Rich KM, Luszczynski JR, Osborne PA, et all. Nerve growth factor protects adult sensory neurons from cell death and atrophy caused by nerve injury. J Neurocytol. 1987;16:261-8.

Luizzi J, Tedeschi B. Peripheral nerve regeneration in: Neurosurgery clinics of north America p:31-39,1991

Brushart TM, Aspalter M, Griffin JW, et al. Schwann cell phenotype is regulated by axon modality and central-peripheral location, and persists in vitro. Exp Neurol. 2013;247:272-81

Fu SY, Gordon T. Contributing factors to poor functional recovery after delayed nerve repair: prolonged denervation. J Neurosci. 1995;15(5 Pt 2):3886-95.

Caplan J, Tiangco AD, Terzis JK. Effects of IGF-II in a new end- to-side model. J Reconstr Microsurg 1999;5:351–8.

Al-Qattan MM, Al-Thunyan A. Variables affecting axonal regeneration following end-to-side neurorrhaphy. Br J Plast Surg 1998;51:238–42.

Irintchev A, Draguhn A, Wernig A. Neuroscience. Reinnervation and recovery of mouse soleus muscle after long-term denervation. 1990;39:231-43.

Li L, Houenou LJ, Wu W, et al. Characterization of spinal motoneuron degeneration following different types of peripheral nerve injury in neonatal and adult mice. J Comp Neurol. 1998;396:158-68.

10. 10. Gutmann E, Guttmann L. The effect of galvanic exercise on denervated and re-innervated muscles in the rabbit. J Neurol Psychiatry. 1944;7:7-17.

11. Erb DE, Mora RJ, Bunge RP. Reinnervation of adult rat gastrocnemius muscle by embryonic motoneurons transplanted into the axotomized tibial nerve. Exp Neurol. 1993;124:372-6.

12. Ochi M, Kwong WH, Kimori K, et al. Delay of the denervation process in skeletal muscle by sensory ganglion graft and its clinical application. Plast Reconstr Surg. 1996;97:577-86.

13. Lundborg G1, Zhao Q, Kanje M, et al. Can sensory and motor collateral sprouting be induced from intact peripheral nerve by end-to-side anastomosis? J Hand Surg Br. 1994;19:277-82.

14. Yüksel F, Karacaoğlu E, Güler MM. Plast Reconstr Surg. Nerve regeneration through side-to-side neurorrhaphy sites in a rat model: a new concept in peripheral nerve surgery. 1999;104:2092-9.

15. Tham SK, Morrison WA. Motor collateral sprouting through an end-to-side nerve repair. J Hand Surg Am. 1998;23:844-51.

16. Caplan J1, Tiangco DA, Terzis JK. Effects of IGF-II in a new end-to-side model. J Reconstr Microsurg. 1999;15:351-8.
Medicine Science-Cover
  • ISSN: 2147-0634
  • Yayın Aralığı: Yılda 4 Sayı
  • Başlangıç: 2012
  • Yayıncı: Effect Publishing Agency ( EPA )
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