Nodular formation of thyroid tissue is a very common endocrinologic pathology. Approximately 5% of thyroid nodules can prove to be cancerous. The usefulness of mean platelet volüme(MPV) and neutrophil to lymphocyte ratio (NLR) is determined as an indicator of immunological response and subclinical inflammation in recent years. In this study we evaluate the association of thyroid stimulating hormone (TSH), platelet, mean platelet volüme(MPV) and NLR levels between the thyroid nodules that turn into cancer and do not convert. Our study consisted of patients with thyroid nodules that converted to thyroid cancer (n = 100) and didn’t convert to thyroid cancer (n = 100). These patients were selected retrospectively using the Hospital Information System. The TSH, NLR, platelet and MPV levels were recorded preoperatively and the difference between them was evaluated statistically with SPSS 21. Differences between groups were examined with using Mann Whitney U Test. P
___
1. Reiners C, Wegscheider K, Schicha H, et al. Prevalence of thyroid disorders in the working population of Germany: ultrasonography screening in 96,278 unselected employees. Thyroid. 2004;14:926-32.
2. Frates MC, Benson CB, Doubilet PM, et al. Prevalence and distribution of carcinoma in patients with solitary and multiple thyroid nodules on sonography. J Clin Endocrinol Metab. 2006;91:3411-7.
3. Pellegriti G, Frasca F, Regalbuto C, et al. Worldwide increasing incidence of thyroid cancer: update on epidemiology and risk factors. J Cancer Epidemiol. 2013;2013:965212.
4. Fugazzola L, Colombo C, Perrino M, et al. Papillary thyroid carcinoma and inflammation. Front Endocrinol. 2011;2:88.
5. Balkwill F., Mantovani A. Inflammation and cancer: back to Virchow? Lancet. 2001;357,539–54510.
6. Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144:646–74.
7. Oflazoğlu U, Alacacıoğlu A, Somalı I ve ark. Nötrofil/Lenfosit Oranı, Trombosit/Lenfosit Oranı ve Ortalama Trombosit Hacminin Kolorektal Karsinomlu Hastalardaki Prognostik Değeri [İzmir Oncoloji Grubu (IZOG) Çalışması]. Acta Oncologica Oncologica.
8. Mangalpally KK, Siqueiros-Garcia A, Vaduganathan M, et al. Platelet activation patterns in platelet size subpopulations: differential responses to aspirin in vitro. J Thrombosis Thrombolysis. 2010;30:251-62.
9. Liu CL, Lee JJ, Liu TP, et al. Blood neutrophil-to-lymphocyte ratio correlates with tumor size in patients with differentiated thyroid cancer. J Surg Oncol. 2013;107:493-7
10. Seretis C, Gourgiotis S, Gemenetzis G, et al. The significance of neutrophil/lymphocyte ratio as a possible marker of underlying papillary microcarcinomas in thyroidal goiters: a pilot study. Am J Surg. 2013;205:691– 6.
11. Perisanidis C, Kornek G, Pöschl PW, et al. High neutrophil-tolymphocyte ratio is an independent marker of poor disease-specific survival in patients with oral cancer. Med Oncol. 2013;30:334
12. Chen J, Deng Q, Pan Y, et al. Prognostic value of neutrophil-tolymphocyte ratio in breast cancer. FEBS Open Bio. 2015;5:502–7
13. Ozdemir Y, Akin ML, Sucullu I, Balta AZ, Yucel E. Pretreatment neutrophil/lymphocyte ratio as a prognostic aid in colorectal cancer. Asian Pac J Cancer Prev. 2014;15:2647–50.
14. McLeod DSA, Watters KF, Carpenter AD, et al. Thyrotropin and thyroid cancer diagnosis: A systematic review and dose-response meta-analysis. J Clin Endocrinol Metab. 2012;97:2682–92.
15. Kocer D, Karaman H, Karakukcu C. May the neutrophil/lymphocyte ratio be a predictor in the differentiation of different thyroid disorders? Asian Pac J Cancer Prev, 2015;16:3875-9.
16. Kim BW, Yousman W, Wong WX, et al. Less is more: comparing the 2015 and 2009 American thyroid association guidelines for thyroid nodules and cancer. Thyroid. 2016;26:759-64.
17. Bayır O, Polat R, Saylam G, et al. The principles of differentiated thyroid cancer surgery and anesthesia in pregnancy: three case reports. Tr-ENT. 2015;25:350-6.
18. Voutsadakis IA. Thrombocytosis as a prognostic marker in gastrointestinal cancers. World J Gastrointest Oncol. 2014;6:34–40
19. Golbert L, de Cristo AP, Faccin CS, et al. Serum TSH levels as a predictor of malignancy in thyroid nodules: A prospective study. Plos One. 2017;12:e0188123.
20. Cho J, Yoon J, Park M, et al. Age and prognosis of papillary thyroid carcinoma: retrospective stratification into three groups: J Korean Surg Soc, 2012;83:259–66.
21. Liu J, Du J, Fan J et al. The neutrophil-to-lymphocyte ratio correlates with age in patients with papillary thyroid carcinoma. Orl, 2015;109–16.
22. Haymart MR, Cayo M, Herbert Chen. Papillary thyroid microcarcinomas: big decisions for a small tumor. Ann Surg Oncol. 2009;16:3132–9.