Comparison of antivenom effects between pediatric and adult patients presented to emergency department with scorpion stings

The aim of this study was to compare the use of antivenom, and admission to ICU, scorpinism between adult and pediatric patients. This study included 99 patients who were admitted to the emergency department with scorpion sting within 1 year. Patients’ demographics including age and gender, and clinical findings such as ionized Ca values, body region of sting contact and complications were recorded from the patient files and hospital records. In addition, regarding management of patients with scorpionism the use of antivenoms, admission to intensive care unit and complications developed by the patients were also recorded. Patients were divided into two groups according to age as the pediatric group including patients aged ≤ 18 years (Group 1) old and the adult group consisting of patients aged> 18 years old (Group 2). Antivenom administration was performed in 12 patients (12.2%). Antivenom was administered in 38% (n=8) of the patients in Group 1 and 5.13% (n=4) of the patients in Group 2. The mean age of patients who received antivenom was statistically significantly lower than the patients who did not receive antivenom (p

___

1. Coorg V, Levitan RD, Gerkin RD, et al. Clinical presentation and outcomes associated with different treatment modalities for pediatric bark scorpion envenomation. J Med Toxicol. 2017;13:66-70.

2. Chippaux JP. Emerging options for the management of scorpion stings. Drug Des Devel Ther. 2012;6:165-73.

3. Ozkan O, Uzun R, Adigüzel S, et al. Evaluation of scorpion sting incidence in Turkey. J Venom Anim Toxins incl Trop Dis. 2008;14:128-40.

4. Yılmaz F, Arslan ED, Demir A, et al. Epidemiologic and clinical characteristics and outcomes of scorpion sting in the southeastern region of Turkey. Ulus Travma Acil Cerr Derg 2013;19:417-22.

5. Del Brutto OH. Neurological effects of venomous bites and stings: snakes, spiders, and scorpions. Handb Clin Neurol. 2013;114:349-68.

6. Al-Asmari A, Manthiri RA, Abdo N, et al. Saudi medicinal plants for the treatment of scorpion sting envenomation. Saudi J Biol Sci. 2017;24:1204-11.

7. Nasim MJ, Asad MH, Sajjad A, et al. Combating of scorpion bite with Pakistani medicinal plants having ethno-botanical evidences as antidote. Acta Pol Pharm. 2013;70:387-94.

8. Sahin A, Arici MA, Hocaoglu N, et al. Antivenom use in bite and sting cases presenting to a public hospital. Ulus Travma Acil Cerrahi Derg. 2018;24:343-50.

9. Dudin AA, Rambaud-Cousson A, Thalji A, et al. Scorpion sting in children in the Jerusalem area: a review of 54 cases. Ann Trop Paediatr. 1991;11:217-23.

10. Abimannane A, Rameshkumar R, Satheesh P, et al. Second dose of scorpion antivenom in children with Indian red scorpion (Mesobuthus tamulus) sting envenomation. Indian Pediatr. 2018;55:315-8.

11. Dokur M, Dogan M, Yagmur EA. Scorpion-related cardiomyopathy and acute pulmonary edema in a child who is stung by Leiurus abdullahbayrami. Turk J Emerg Med. 2017;17:104-8.

12. Oyedeji OA, Musa TL, Adebami OJ, et al. Fatal scorpion sting in a child. Niger J Clin Pract. 2014;17:112-4.

13. Ahmed AE, Abdel-Baseer KA, Saad K, et al. Endocrinological and biochemical changes of scorpionism in children in Upper Egypt. Ther Adv Endocrinol Metab. 2015;6:210-6.

14. Abourazzak S, Achour S, El Arqam L, et al. Epidemiological and clinical characteristics of scorpion stings in children in Fez, Morocco. J Venom Anim Toxins inci Trop Dis 2009;15:255-67.

15. Bawaskar HS, Bawaskar PH. Management of scorpion sting. Heart. 1999;82:253-4.

16. Gümüştekin M. Çevresel toksinler: Hayvan ısırma ve sokmaları. T Klin J Pharmacol. 2003;1:53-7.

17. Furtado SDS, Belmino JFB, Diniz AGQ, et al. Epidemiology of scorpion envenomation in the state of Ceará Northeastern Brazil. Rev Inst Med Trop Sao Paulo. 2016;58:15.

18. Kang AM, Brooks DE. Nationwide scorpion exposures reported to US poison control centers from 2005 to 2015. J Med Toxicol. 2017;13:158-65.

19. Nejati J, Saghafipour A, Rafinejad J, et al. Scorpion composition and scorpionism in a high-risk area, the southwest of Iran. Electron Physician. 2018;10:7138-45.

20. O’Connor A, Ruha AM. Clinical course of bark scorpion envenomation managed without antivenom. J Med Toxicol. 2012;8:258-62.

21. Boyer L, Degan J, Ruha AM, et al. Safety of intravenous equine F(ab’)2: insights following clinical trials involving 1534 recipients of scorpion antivenom. Toxicon. 2013;76:386-93.

22. Mishra OP, Prasad R. Myocardial dysfunction in children with scorpion sting envenomation. Indian Pediatr. 2015;52:291-2.

23. Pandi K, Krishnamurthy S, Srinivasaraghavan R, et al. Efficacy of scorpion antivenom plus prazosin versus prazosin alone for mesobuthus tamulus scorpion sting envenomation in children: A randomised controlled trial. Arch Dis Child. 2014;99:575-80.

24. Natu VS, Kamerkar SB, Geeta K, et al. Efficacy of anti-scorpion venom serum over prazosin in the management of severe scorpion envenomation. J Postgrad Med. 2010;56:275-80.

25. Hammoudi-Triki D, Ferquel E, Robbe-Vincent A, et al. Epidemiological data, clinical admission gradation and biological quantification by ELISA of scorpion envenomations in Algeria: effect of immunotherapy. Trans R Soc Trop Med Hyg. 2004;98:240-50.

26. Sevcik C, D’Suze G, Díaz P, et al. Modelling Tityus scorpion venom and antivenom pharmacokinetics. Evidence of active immunoglobulin G’s F(ab’)2 extrusion mechanism from blood to tissues. Toxicon. 2004;44:731-41.

27. Ghalim N, El-Hafny B, Sebti F, et al. Scorpion envenomation and serotherapy in Morocco. Am J Trop Med Hyg. 2000;62:277-83.

28. Krishnamurthy S, Mahadevan S. Efficacy of scorpion antivenom in children. Indian Pediatr. 2014;51:499-500.

29. Dehesa-Davila M, Possani LD. Scorpionism and serotherapy in Mexico. Toxicon. 1994;32:1015-8.

30. Ismail M. The treatment of the scorpion envenoming syndrome: the Saudi experience with serotherapy. Toxicon. 1994;32:1019-26.

31. de Silva HA, Ryan NM, de Silva HJ. Adverse reactions to snake antivenom, and their prevention and treatment. Br J Clin Pharmacol 2016;81:446-52.

32. Dissanayake V, Dalka ET, Koh C, et al. A pilot study on the management and outcomes of self-poisoning in a rural Ugandan Emergency Centre. Afr J Emerg Med. 2018;8:25-28.

33. Bawaskar HS, Bawaskar PH. Efficacy and safety of scorpion antivenom plus prazosin compared with prazosin alone for venomous scorpion (Mesobuthus tamulus) sting: randomised open label clinical trial. BMJ. 2011;342:7136.
Medicine Science-Cover
  • ISSN: 2147-0634
  • Yayın Aralığı: 4
  • Başlangıç: 2012
  • Yayıncı: Effect Publishing Agency ( EPA )
Sayıdaki Diğer Makaleler

The role of ductus venosus doppler, fetal liver length and placental thickness in gestational diabetes

Murat CEVİK, Ruya DEVEER

Mid-term outcome of wide resection in musculoskeletal fibrosarcoma patients

Resit SEVİMLİ, Adem EMELİ, Semih ERİTEN

Serum angiostatin levels in diabetic patients with heart failure taking oral antidiabetic therapy or basal insulin and its clinical significance

Birol YİLDİZ, Ismail ERTÜRK, Galip BUYUKTURAN, Bilgin Bahadir BASGOZ, Ramazan ACAR, Kenan SAGLAM

Surgeon factor in pediatric supracondylar humerus fractures

Ali YUCE, Niyazi IGDE, Yunus IMREN, Suleyman Semih DEDOGLU, Hakan GURBUZ

The relationship between spiritual well-being and hopelessness levels of substance users

Pinar SOYLAR, Ufuk DOGAN

Comparison of the caregiver burden of the mothers of children with cerebral palsy and healthy children

Ercan KAYDOK, Sezin SOLUM, Nesibe Sultan CİNAROGLU

Disturbed sleep quality and increased depression scores in alopecia areata patients

Aynure OZTEKİN, Coskun OZTEKİN

Volume of intensive care unit patients in the emergency department: clinical experience in a training and research hospital

Murat GUZEL, Şener CİNDORUK, Mehmet Tevfik DEMİR, Mehmet YORGUN, Emre OZGEN, Erdinc YAVUZ, Murat YUCEL, Ahmet BAYDİN

A retrospecti̇ve evaluation of the epitelial lesions / neoplasms of the gallbladder in Uşak city and determination of the visual frequency

Sirin KUCUK, Cengiz KOCAK, Ersoy ERCİHAN, Asli Ucar UNCU, Mehmet GUNDOGAN

The effect of gestational hypertension on the maternal mean platelet volume

Emre BASER, Funda SALGUR, Melek BİLGE, Safak OZDEMİRCİ, Eylem UNLUBİLGİN, Ozlem Moraloglu TEKİN, Deniz ESİNLER, Aykan YUCEL