Comparison of the algan hemostatic agent with celox in rat femoral artery bleeding model

Comparison of the algan hemostatic agent with celox in rat femoral artery bleeding model

The most important reasons of deaths after a trauma are major vascular injury. The effective and speedy control of the hemorrhage is crucial in reducing such deaths. Although many products are being used for this topic, most effective products have not yet been developed currently, and there is an urgent need for effective hemostatic. The aim of this study is to compare the efficacy of Algan hemostatic agent (AHA) with Celox in femoral artery incision model in rats. A total of 28 wistar albino rats divided into 4 equal groups. Experimental femoral artery injury was inflicted. In the control group, saline impregnated gauze was employed. AHA impregnated sponge, AHA powder, and Celox in powder form were utilized in the experimental groups. According to the results, there was no difference in bleeding control between AHA and C (p>0.05). When compared to the control group, AHA and Celox were found to be very effective in bleeding control (p

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  • 1. Sauaia A, Moore FA, Moore EE, et al. Epidemiology of trauma deaths: a reassessment. J Trauma Acute Care Surg. 1995;38:185-193.
  • 2. Champion HR, Bellamy RF, Roberts CP, et al. A profile of combat injury. J Trauma Acute Care Surg. 2003;54:13-19.
  • 3. Carson J, Spence R, Poses R, et al. Severity of anaemia and operative mortality and morbidity. Lancet. 1988;331:727-9.
  • 4. Wu WC, Trivedi A, Friedmann PD, et al. Association between hospital intraoperative blood transfusion practices for surgical blood loss and hospital surgical mortality rates. Ann surg. 2012;255:708-14.
  • 5. Huri E, Akgül KT, Yücel MÖ, Aet al. The second step in vitro trial of Ankaferd® Bloodstopper®: comparison with other hemostatic agents. Turk J Med Sci. 2011;41:7-15.
  • 6. Hanks JB, Kjaergard HK, Hollingsbee DA. A comparison of the haemostatic effect of Vivostat® patient-derived fibrin sealant with oxidised cellulose (Surgicel®) in multiple surgical procedures. Eur Surg Res. 2003;35:439- 444
  • 7. Aydinoglu A, Ersoy G, Dogan A, et al. Hemostatic effect of microporous polysaccharide hemosphere in a heparinized rat model with femoral artery bleeding. Eur J Emerg Med. 2008;15:286–306.
  • 8. Akarsu C, Kalaycı MU, Yavuz E,et el. Comparison of the hemostatic efficiency of Ankaferd Blood Stopper and fibrin glue on a liver laceration model in rats. Ulus Travma Acil Cerrahi Derg. 2011;17:308-12.
  • 9. Jackson MR. New and potential uses of fibrin sealants as an adjunct to surgical hemostasis. Am j surg 2001;182:36-9.
  • 10. Abacıoğlu S, Aydın K, Büyükcam F, et al. Comparison of the efficiencies of buffers containing Ankaferd and Chitosan on hemostasis in an experimental rat model with femoral artery bleeding. Turk J Hematol. 2016;33: 48.-52.
  • 11. Ersoy G, Kaynak, MF, Yilmaz O, et al. Hemostatic effects of microporous polysaccharide hemosphere® in a rat model with severe femoral artery bleeding. Adv ther. 2007;24:485-92.
  • 12. Aktop S, Emekli-Alturfan E, Ozer C, et al. Effects of Ankaferd Blood Stopper and Celox on the tissue factor activities of warfarin-treated rats. Clin Appl Thromb Hemost. 2014;20:16-21.
  • 13. Ozgur D, Gurkan E, Osman Y, et al. The effect of application of local oxidised cellulose powder on hemostasis time in a rat model with femoral artery bleeding. Acta Med Mediterr. 2015;31:179–82.
  • 14. Sabatini L, Trecci A, Imariso D, et al. Fibrin tissue adhesive reduces postoperative blood loss in total knee arthroplasty. J Orthop Trauma. 2012; 13:145-51.
  • 15. Echave M, Oyagüez I, Casado MA. Use of Floseal®, a human gelatinethrombin matrix sealant, in surgery: a systematic review. BMC surg. 2014; 14:111.
  • 16. Richter F, Schnorr D, Deger S, et al. Improvement of hemostasis in open and laparoscopically performed partial nephrectomy using a gelatin matrixthrombin tissue sealant (FloSeal). Urology. 2003;61:73–7.
  • 17. Helito CP, Bonadio, MB, et al. Comparison of floseal® and tranexamic acid for bleeding control after total knee arthroplasty: a prospective randomized study. Clinics. 2019;74:1186.
  • 18. Beyea JA, Rotenberg BW. Comparison of purified plant polysaccharide (HemoStase) versus gelatin-thrombin matrix (FloSeal) in controlling bleeding during sinus surgery: a randomized controlled trial. Ann Otol Rhinol Laryngol. 2011;120:495–8.
  • 19. Testini M, Marzaioli R, Lissidini G, et al. The effectiveness of FloSeal matrix hemostatic agent in thyroid surgery: a prospective, randomized, control study. Langenbecks Arch Surg. 2009;394:837-42.
  • 20. Angioli R, Muzii L, Montera R, et al. Feasibility of the use of novel matrix hemostatic sealant (FloSeal) to achieve hemostasis during laparoscopic excision of endometrioma. J Minim Invasive Gynecol. 2009;16:153–6.
  • 21. Midi, A, Kumandas A, Ekici H,et al. Investigation of the efficacy of algan hemostatic agent in liver laceration model in Rats. EJMO. 2019;3:37-42.
  • 22. Midi A, Ozyurek HE, Karahan S, Eet al. Investigation of efficacy of the plant based algan hemostatic agent in hepatectomy bleeding model in rats. EJMI. 2018;2:195-201.
  • 23. Midi A, Ekici H, Kumandas A, et al. Investigation of the effectiveness of algan hemostatic agent in bleeding control using an experimental partial splenectomy model in rats. Marmara Med J. 2019;32:27-32
  • 24. Midi A, Kumandas A, Ekici H, et al. Investigation of the effectiveness of algan hemostatic agent in renal venous bleeding model in rats. EJMI. 2018;2:129-32.
  • 25. Huri E, Akgül T, Ayyıldız A,et al. Hemostatic role of a folkloric medicinal plant extract in a rat partial nephrectomy model: controlled experimental trial. J urol. 2009;181:2349-54.
  • 26. Song H, Zhang L, Zhao X. Hemostatic efficacy of biological self‐assembling peptide nanofibers in a rat kidney model. Macromol Biosci. 2010;10:33-9. 27. Yasunaga H. Risk of authoritarianism: fibrinogen-transmitted hepatitis C in Japan. Lancet. 2007;370:2063-7.
  • 28. Rhee P, Brown C, Martin M, et al. QuikClot use in trauma for hemorrhage control: case series of 103 documented uses. J Trauma Acute Care Surg. 2008;64:1093-9.
  • 29. Schwab PE, Thienpont E. Use of a haemostatic matrix (FloSeal®) does not reduce blood loss in minimally invasive total knee arthroplasty performed under continued aspirin. Blood Transf. 2016;14:134.
  • 30. Kauvar DS, Lefering R, Wade CE. Impact of hemorrhage on trauma outcome: an overview of epidemiology, clinical presentations, and therapeutic considerations. J Trauma Acute Care Surg. 2006;60:3-11.
Medicine Science-Cover
  • ISSN: 2147-0634
  • Yayın Aralığı: 4
  • Başlangıç: 2012
  • Yayıncı: Effect Publishing Agency ( EPA )
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