Dilek ÖZÇELİK SOBA, Yasemin ÖZDAMAR EROL, Burcu KAZACI, Çağrı İLHAN

Retinopatisi Olmayan Diyabetik Gözlerde Glikolize Hemoglobin (HbA1c) Düzeyi ile Merkezi Korneal ve Maküler Kalınlık Arasındaki İlişki

Amaç: Tip 2 diyabetik hastaların santral kornea (SKK) ve maküler foveal kalınlıklarının (SMK) sağlıklı bir kontrol grubu ile karşılaştırılması ve açlık kan şekeri (AKŞ), hemoglobin A1c (HbA1c) düzeyleri ve diyabet süresine göre farkın belirlenmesi amaçlanmıştır. Gereç ve Yöntemler: Retinopatisi olmayan 50 diyabetik hasta ve benzer yaş ve cinsiyet özelliği gösteren 47 sağlıklı kontrol karşılaştırıldı. SKK’de art arda üç kornea kalınlığı ölçümünün ortalaması Pentacam HR ımaging system (Oculus Optikgeräte GmbH, Wetzlar, Germany) ile ve maküla kalınlığı Heildenberg optik koherens tomografi (OKT) ile elde edildi. Tüm katılımcıların AKŞ ve HbA1c seviyeleri değerlendirildi. Analiz sağ göze yapıldı. Bulgular: Yaş ve cinsiyet açısından gruplar istatistiksel olarak benzerlik göstermekteydi (p>0,05). Diyabetik hastaların AKŞ ve HbA1c değerleri sağlıklı kontrollere göre anlamlı olarak yüksek ve HbA1c değerleri %8’in altında olan tip 2 diabetes mellitus hastalarının yüzdesi sağlıklı kontrollerden anlamlı olarak düşüktü (p0,05). Sonuç: Çalışmamızda retinopatisi olmayan diyabetik katılımcılarda, diyabetik olmayan kontroller arasında SKK ve SMK açısından fark yoktu. Bu sonuç maküla ve kornea kalınlığının retinopati ve keratopatinin bir göstergesi olarak kullanılamayacağını göstermiştir.

Associations Between Glycosylated Hemoglobin (HbA1c) Level and Central Corneal and Macular Thickness in Diabetic Eyes Without Retinopathy

Objective: The comparison of a central corneal (CCT) and central foveal thickness (CMT) of type 2 patients with diabetes with a healthy control group and determine the difference according to fasting blood glucose (FBG), hemoglobin a1c (HbA1c) levels and time of diabetes. Materials and Methods: Fifty patients with diabetes without retinopathy and 47 healthy controls of similar age and gender were compared. The mean of three consecutive corneal thickness measurements at the central cornea was obtained by the Pentacam HR imaging system (Oculus Optikgeräte GmbH, Wetzlar, Germany) and macular thickness was obtained by Heildenberg optical coherence tomography (OCT). The fiber Bragg grating (FBG) and HbA1c levels of all participants were evaluated. The analysis was performed on the right eye. Results: Groups were statistically similar in terms of age and gender (p>0.05). Patients with diabetes had significantly higher FBG and HbA1c values than controls and the percentage of patients with HbA1c values less than 8% in Type 2 diabetes mellitus was significantly lower than healthy controls (p0.05). Conclusion: In our study, diabetic participants without DR had no difference at CCT and CMT between non-diabetic controls. This result shown that the macula and corneal thickness cannot be used as indicators of retinopathy and keratopathy.

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