Tip 2 Diabetes Mellitus Hastalarında Glisemik Kontrol Tahmininde Trigliserit-HDL Oranı ve Trigliserit-glukoz İndeksinin Rolü

Amaç: Amacımız, diyabetli hastalarda kan şekeri regülasyonunu trigliserit glikoz indeksi ve trigliseritin yüksek yoğunluklu lipoprotein’e (HDL) oranını temel alarak değerlendirmektir. Gereç ve Yöntemler: Retrospektif çalışmamızın verileri hastanemizin veri tabanından elde edilmiştir. Çalışma 340 tip 2 diyabet hastası ile yapılmıştır. Hastaların demografik verileri, glukoz, hemoglobin A1c (HbA1c), HDL-kolesterol, trigliserit, alanin aminotransferaz (ALT), kreatinin değerleri kayıt edildi. Çalışmadan elde edilen veriler SPSS 21 versiyon program ile değerlendirildi. Bulgular: Katılımcıların 202'si kadın, 138'i erkekti. Hastalar HbA1c yüzdelerine göre gruplara ayrıldı. HbA1c ≥%7 olan grupta trigliserit/HDL değeri, trigliserit-glukoz indeksi, açlık glukozu, diyabet yaşı, trigliserit değerleri istatistiksel olarak anlamlı daha yüksek iken HDL kolesterol daha düşüktü. Trigliserit/HDL değeri ve trigliserit glukoz indeksi ile hem glukoz ve hem HbA1c arasında anlamlı bir ilişki saptandı. Kötü glisemik kontrollü (HbA1c ≥%7) hastalar için trigliserit-glukoz indeksi için cut-off değer 9,38 olarak saptandı. Sonuç: Trigliserit/HDL ve trigliserit-glikoz (TyG) indeks değerleri HbA1c ile ilişkilidir. Özellikle bu iki parametre arasından cut-off değeri belirlenen TyG indeksi, HbA1c bakılamayan durumlarda HbA1c yerine iyi glisemik kontrolü değerlendirmek için kullanılabilecek bir parametredir.

The Role of Triglyceride-HDL Ratio and Triglyceride-glucose Index in Estimating Glycemic Control in Patients with Type 2 Diabetes Mellitus

Objective: Our aim is to evaluate blood glucose regulation in patients with diabetes using the triglyceride glucose index and the triglyceride to high density lipoprotein (HDL) ratio. Materials and Methods: The data of our retrospective study were obtained from the database of our hospital. The study was conducted with 340 type 2 patients with diabetes. Demographic data of the patients, glucose, hemoglobin A1c (HbA1c), high density lipoproteine-cholesterol (HDL-C), triglyceride, alanine aminotransferase (ALT) and creatinine values were recorded. The value obtained from the study was evaluated with the SPSS 21 version program. Results: Of the participants, 202 were female and 138 were male. Patients were divided into groups according to the percentage of HbA1cs. In the group with HbA1c ≥7%, triglyceride/HDL value, triglyceride-glucose index, fasting glucose, diabetes age, triglyceride values were statistically significantly higher, while HDL cholesterol was lower. We found a significant correlation between Triglyceride/HDL value, triglyceride glucose index with both glucose and HbA1c. The cut-off value of triglyceride-glucose (TyG) was 9.38. Conclusion: TG/HDL and TyG index values are related with HbA1c. In particular, the TyG index, whose cut-off value determined between these two parameters, is a parameter that can be used to evaluate good glycemic control instead of HbA1c in cases where HbA1c cannot be measured.

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