UFUK ERYILMAZ, SALİHA AKSUN, BUKET DEMİRCİ

Protective Effect of Pycnogenol® on Cisplatin Induced-Cardiotoxicity in Rats

Objective: This study investigated the cardiotoxicity of cisplatin (CIS) on rat heart by using the oxidative damage of the rat myocardium, troponin I and serum S100A1 levels. Previous studies have reported that cell-protective effect of Pycnogenol® (PYC) depended on its antioxidant and anti-inflammatory properties. Hence, the myocardial protective effect of PYC was investigated in this study. Materials and Methods: Rats were randomly grouped to four with 5 rats in each group. The groups were consisted of control group, PYC group: 10 mg/kg PYC for 7 days, CIS group: 15 mg/kg single injection of CIS on the 5th day, CIS + PYC group: 10 mg/kg PYC for 7 days, plus 15 mg/kg single injection of CIS on the 5th day. Heart and serum samples were acquired subsequently. Results: CIS and PYC co-treatment group had increased catalase level (from 43.61±15.16 to 60.80±21.36, p

Pycnogenol®’ün Sıçanlarda, Sisplatin ile İndüklenen Kardiyotoksisite Üzerine Koruyucu Etkisi

Amaç: Bu çalışmada sıçan kalbi üzerinde sisplatin (CIS) kardiyotoksisitesi, sıçan miyokardı oksidatif hasarını, troponin I ve serum S100A1 düzeyleri kullanılarak araştırılmıştır. Önceki çalışmalar, Pycnogenol®’un (PYC) hücre koruyucu etkisinin antioksidan ve anti-enflamatuvar özelliklerine bağlı olduğunu bildirmiştir. Bu nedenle, bu çalışmada PYC’nin miyokardiyal koruyucu etkisi araştırılmıştır. Gereç ve Yöntemler: Sıçanlar randomize olarak grup başına 5 olacak şekilde dört gruba ayrıldı. Kontrol grupları, PYC grubu: 10 mg/kg 7 gün boyunca intraperitoneal PYC, 5 gün intraperitoneal olarak sisplatinin 15 mg/kg tek doz enjeksiyonu, sisplatin + PYC grubu: 10 mg/kg PYC intraperitoneal olarak 7 gün boyunca, artı beşinci günde 15 mg/kg tek sisplatin enjeksiyonu. Kalp ve serum örnekleri 8. günde elde edildi. Bulgular: CIS ve PYC eş-tedavi grubunda katalaz seviyesi artmış (43,61±15,16'dan 60,80±21,36’ya, p

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