SUZAN DEMİR PEKTAŞ, EMİNE TUĞBA ALATAŞ, GÜRSOY DOĞAN, SALİM NEŞELİOĞLU, ÖZCAN EREL

A Marker for Evaluation of Oxidative Stress in Patients with Alopecia Areta: Thiol-Disulphide Homeostasis

Objective: Alopecia areata (AA) is a disorder characterized by non-scarring hair loss, whose etiology involves oxidative stress. We aimed to determine the role of thiol/disulphide levels in AA pathogenesis and to investigate if they can be used as its marker. Materials and Methods: This prospective study included 100 AA patients who presented to dermatology outpatient clinic and 100 healthy controls without any systemic and/or inflammatory dermatological disorder. The control and study groups were compared with respect to native thiol, total thiol, and disulphide levels, and disulphide/native thiol, disulphide/total thiol, and native thiol/total thiol ratios. The relationships between demographic and lesion characteristics, native thiol, total thiol, and disulphide levels, and disulphide/native thiol, disulphide/total thiol, and native thiol/total thiol ratios were studied. Results: The mean age of AA patients was 37.5 years. Fifty-eight (58%) patients were male, and the median body mass index was 24 kg/m2. Median age was significantly higher in the AA group (p

Alopesi Areata Tanılı Hastalarda Oksidatif Stresin Değerlendirilmesinde Bir Belirteç: Tiyol-Disülfid Homeostazı

Amaç: Alopesi areata (AA) etiyolojisinde oksidatif stresin rol aldığı, skarsız kıl kaybı ile karakterize bir hastalıktır. AA hastalarında tiyol/disülfid düzeylerine bakarak AA patogenezindeki rolünü ve AA patogenezinde bir belirteç göstergesi olup olmayacağının araştırılması amaçlanmıştır. Gereç ve Yöntemler: Bu kesitsel çalışma 27.07.2016-01.02.2017 tarihleri arasında dermatoloji polikliniğine başvuran AA tanısı alan 100 hasta ve herhangi bir sistemik ve/veya enflamatuvar deri hastalığı olmayan 100 gönüllü kontrol grubunda gerçekleştirildi. Kontrol ve hasta grubu arasında nativ tiyol, total tiyol, disülfid düzeyi, disülfid/nativ tiyol, disülfid/total tiyol ve nativ tiyol/total tiyol oranları karşılaştırıldı. AA hastalarının demografik ve lezyon özellikleri ile nativ tiyol, total tiyol, disülfid düzeyi, disülfid/nativ tiyol, disülfid/total tiyol ve nativ tiyol/total tiyol oranları arasındaki ilişki incelendi. Bulgular: AA’lı hastaların yaş ortalaması 34,9±10,4 yıl, %58’i erkek ve vücut kitle indeksi ortancası 24 kg/m2 olup, kontrol grubu ile yaş ortalaması açısından farklılık saptanmadı (p>0,05). AA hastalarında total tiyol düzeyi, nativ tiyol düzeyi ve nativ tiyol/total tiyol oranında düzeylerinde anlamlı düşüklük saptanırken; disülfid düzeyi, disülfid/nativetiyol ve disülfid/total tiyol oranlarında anlamlı yükseklik saptandı (p0,05). Sonuç: AA hastalarında mevcut mekanizmalardan biri oksidatif stres artışıdır. AA grubunda tiyol/disülfid hemostazı oksidatif stres lehine bozulmuş olup, bu hastalarda tiyollerde azalma, disülfid miktarında artma belirlenmiştir.

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