Lipid Peroxidation and Antioxidant Activity in Normal and Preeclampsic Pregnancies

Serbest radikallerin oluşumu normal fizyolojik bir süreçtir ve bu serbest radikaller lipidler üzerinde lipidperoksidasyonuna yol açmaktadır. Bununla birlikte insan vücut hücreleri bir takım antioksidan savunmasistemleri geliştirmişlerdir. Lipid peroksidasyonu-antioksidan dengesi hayatın her evresinde olduğu gibihamilelik döneminde de hem annenin hem de fetüsün fizyolojik fonksiyonlarını sürdürebilmesi için önemtaşımaktadır. Hamilelik boyunca artan plasental lipoperoksidatif aktivite hem plasentaya hem de fetüse olumsuzetkiler yapmaktadır. Preeklamptik hamileliklerde ise vasküler endotel hücre disfonksiyonuna bağlı olarak lipidperoksidasyonundaki artış bu durumu çok daha dramatik bir hale getirmektedir. Bu yüzden antioksidan savunmasisteminin devreye girip girmemesi durumun seyri açısından oldukça önem taşımaktadır. Son yıllarda yapılançalışmalarda, lipid peroksidasyonundaki yükselmeye karşın antioksidan sisteminin devreye girmediğidurumlarda eksojen vitamin takviyesinin gerekebileceği ve bu müdahalenin hem annenin hem de fetüsün hayatıiçin koruyucu olabileceği belirtilmektedir

Anahtar Kelimeler:

Lipid peroksidasyonu, antioksidan savunma sistemi, hamilelik, preeklampsi

Lipid Peroxidation and Antioxidant Activity in Normal and Preeclampsic Pregnancies

The formation of free radicals is a normal physiological course and free radicals which act on lipids cause to lipid peroxidation. Nevertheless, all human body cells have developed a set of antioxidant defence system. During pregnancy, the balance between lipid peroxidation and antioxidant defence system is also important as all terms of the human life for resuming the basic physiological functions of both mother and her fetus. Increasing on placental lipoperoxidative activity during pregnancy could effect the placenta and fetus unfavorably. In preeclamptic pregnancies, vasculer endothelial cell disfunction could rise the lipid peroxidation more dramatically. Therefore, intervening the antioxidant defence system is highly vital for the prognosis of the condition. According to the recent studies, antioxidant vitamin supplement can be required whether the antioxidant system doesn't step in against to the lipid peroxidation and this treatment could protect the life of mother and her fetus.

Keywords:

Lipid peroxidation, antioxidant defence system, pregnancy, preeclampsia,

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Yalin S, Sahin NO, Comelekoglu U, Yalin E, Bagis S,
Hatungil R, Yalin S, Comelekoglu U, Bagis S, Sahin
NO, Arslan H, Eroglu P, Berkoz M. Cadmium induced
changes in lipid peroxidation and antioxidant status in
brain of ovariectomized rats. Asian J Chem
;18:1467-73. 3. Jacob RA, Burr BJ. Oxidative damage and defence.Am
J Clin Nutr 1996;63:985-90. 4. Little RE, Gladen BC. Levels of lipid peroxides in
uncomplicated pregnancy: a review of the literature.
Reprod Toxicol 1999;13:347-52. 5. Verit FF, Erel O, Sav M, et al. Oxidative stress is
associated with clinical severity of nausea and
vomiting of pregnancy.Am J Perinat 2007;24:545-8 6. Eiben B, Glaubitz R. First-trimester screening: an
overview. J Histochem Cytochem 2005; 53:281-3. 7. Myatt L, Cui XL. Oxidative stress in the placenta.
Histochem Cell Biol 2004;122:369-82. 8. Wang J, Mimuro S, Lahoud R, Trudinger B, Wang XL.
Elevated levels of lipoprotein(a) in women with
preeclampsia.Am J Obstet Gynecol 1998;178:146-9. 9. Poranen AK, Ekblad U, Uotila P, et al. Lipid
peroxidation and antioxidants in normal and pre
eclamptic pregnancies. Placenta 1996;17:401-5. 10. Pentieva K, Ivanova L, Petrova S, Ovcharova D,
Vatralova K, Angelova K. Changes in the level of lipid
peroxidation in healthy pregnant women. Akush
Ginekol 1995;34:19-21. 11. Wang Y, Walsh SW, Kay HH. Placental tissue levels of
nonesterified polyunsaturated fatty acids in normal and
preeclamptic pregnancies. Hypertens Pregnancy
;24:235-45. 12. Walsh SW, Wang Y. Secretion of lipid peroxides by the
human placenta.Am J Obstet Gynecol 1993;169:1462- 6. 13. Hubel CA. Oxidative stress in the pathogenesis of
preeclampsia. Proc Soc Exp Biol Med 1999;222:222- 35. 14. Poston L, Raijmakers MTM. Trophoblast oxidative
stress, antioxidants and pregnancy outcome. Placenta 2004;25:72-8. 15. Weinstein L. Syndrome of hemolysis, elevated liver
enzymes, and low platelet count: a severe consequence
of hypertension in pregnancy. Am J Obstet Gynecol
;142:159-67. 16. Seligman SP, Buyon JP, Clancy RM, Young BK,
Abramson SB. The role of nitric oxide in the
pathogenesis of preeclampsia. Am J Obstet Gynecol
;171:944-8. 17. Walsh SW, Wang Y. Trophoblast and placental villous
core production of lipid peroxides, thromboxane, and
prostacyclin in preeclampsia. J Clin Endocrinol Metab
;80:1888-93. 18. Walsh SW. Eicosanoids in preeclampsia. Prostag
Leukotr Ess 2004;70:223-32. 19. Walsh SW, Wang Y. Deficient glutathione peroxidase
activity in preeclampsia is associated with increased
placental production of thromboxane and lipid
peroxides.Am J Obstet Gynecol 1993;169:1456-61. 20. Wang Y, Walsh SW, Guo J, Zhang J. The imbalance
between thromboxane and prostacyclin in
preeclampsia is associated with an imbalance between
lipid peroxides and vitamin E in maternal blood. Am J
Obstet Gynecol 1991;165:1695-700. 21. Walsh SW, Wang Y, Jesse R. Peroxide induces
vasoconstriction in the human placenta by stimulating
thromboxane. Am J Obstet Gynecol 1993;169:1007- 12. 22. Wang Y, Walsh SW, Kay HH. Placental lipid peroxides and thromboxane are increased and prostacyclin is decreased in women with preeclampsia. Am J Obstet
Gynecol 1992;167:946-9. 23. Biri A, Kavutcu M, Bozkurt N, et al. Investigation of
free radical scavenging enzyme activities and lipid
peroxidation in human placental tissues with
miscarriage. J Soc Gynecol Invest 2006;13:384-8. 24. Wisdom SJ, Wilson R, McKillop JH, Walker JJ.
Antioxidant systems in normal pregnancy and in
pregnancy-induced hypertension. Am J Obstet
Gynecol 1991;165:1701-4. 25. Wang YP, Walsh SW.Antioxidant activities and mRNA
expression of superoxide dismutase, catalase, and
glutathione peroxidase in normal and preeclamptic
placentas J Soc Gynecol Invest 1996;3:179-84. 26. WatsonAL, Palmer ME, Jauniaux E, et al. Variations in
expression of copper/zinc superoxide dismutase in
villous trophoblast of the human placenta with
gestational age. Placenta 1997;18:295-9. 27. Mihailovic M, Cvetkovic M, Ljubic A, et al. Selenium
and malondialdehyde content and glutathione
peroxidase activity in maternal and umbilical cord
blood and amniotic fluid. Biol Trace Elem Res 2000;73:47-54. 28. Frendo JL, Therond P, Bird T, et al. Overexpression of
copper zinc superoxide dismutase impairs human
trophoblast cell fusion and differentiation.
Endocrinology 2001;142:3638-48. 29. Zusterzeel PLM, Rutten H, Roelofs HMJ, et al. Protein
carbonyls in decidua and placenta of pre-eclamptic
women as markers for oxidative stres. Placenta 2001;22:213-9. 30. Frendo JL, Therond P, Guibourdenche J, et al.
Modulation of copper zinc superoxide dismutase
expression and activity with in vitro differentiation of
human villous cytotrophoblasts. Placenta
;21:773-81. 31. Mutlu-Turkoglu U, Ademoglu E, Ibrahimoglu L,
Aykac-Toker G, Uysal M. Imbalance between lipid
peroxidation and antioxidant status in preeclampsia.
Gynecol Obstet Invest 1998;46:37-40. 32. Stahl W, Sies H.Antioxidant defense: vitamins E and C
and carotenoids. Diabetes 1997;46:14-8. 33. Ahn YM, Kim YJ, Park H, et al. Prenatal vitamin C
status is associated with placental apoptosis in normal
term human pregnancies. Placenta 2007;28:31-8. 34. Chappell LC, Seed PT, Kelly FJ, et al. Vitamin C and E
supplementation in women at risk of preeclampsia is
associated with changes in indices of oxidative stress
and placental function. Am J Obstet Gynecol
;187:777-84. 35. Cueto SM, Romney AD, Wang YP, et al. Beta-carotene
attenuates peroxide-induced vasoconstriction in the
human placenta J Soc Gynecol Invest 1997;4:64-71. 36. Holles SM, Wang YP, Romney A, et al. Vitamin E
attenuates peroxide-induced vasoconstriction in the
human placenta Hypertens Pregnancy 1997;16:389- 401. 37. Mikhail MS, Anyaegbunam A, Garfinkel D, Palan PR,
Basu J, Romney SL. Preeclampsia and antioxidant
nutrients: Decreased plasma levels of reduced ascorbic
acid, alpha-tocopherol, and beta-carotene in women
with preeclampsia. Am J Obstet Gynecol
;171:150-7. YAZIŞMA ADRESİ Mehmet BERKÖZ
Mersin Üniversitesi Eczacılık Fakültesi, Biyokimya
Anabilim Dalı, MERSİN Telefon Faks
:0 324 341 30 22 E-Posta
:mehmet_berkoz@yahoo.com Geliş Tarihi Kabul Tarihi :25.09.2008