Fatih ÖZNURHAN, Özgül CART, Burak BULDUR, Uğur TUTAR, Cem ÇELİK, Ceylan HEPOKUR

Antimicrobial Efficacy of Chlorhexidine and Licorice Mouthwashes in Children

Objective: The aim of this in vivo study is to evaluate the effectiveness of a simple herbal caries-prevention protocol for reducing salivary Streptococcus mutans levels in children. Materials and Methods: A total of 90 individuals were recruited randomly divided into three groups (n=30). Mouthwashes including chlorhexidine (CHX), licorice and saline were used as tested antimicrobial agents, and saliva samples were collected before rinsing, at the end of 5 min (T1) and 60 min (T2) following rinsing, and the differences were calculated within 5-60 min (T3). Plaques were evaluated following incubation, and counts of the growing colonies were performed in colony forming units (CFU)/mL. Decreases in CFU were calculated in ratio for statistical analysis. Data were analyzed with Kruskal-Wallis, Mann-Whitney U, Friedman and Wilcoxon signed rank tests by Bonferroni correction, using a 0.05 of significance level. Results: CHX caused significantly different decreases for T1 and T2 (p0.05). Conclusion: Licorice might be a useful agent for dental procedures and further studies are needed to learn more about the dose of licorice, the ratio of glycyrrhizin and the duration of dental therapy.

Çocuklarda Meyan Kökü ve Klorheksidin İçerikli Gargaraların Antimikrobiyal Etkinliğinin Değerlendirilmesi

Amaç: Bu in vivo çalışmanın amacı, çocuklarda tükürük Streptococcus mutans (SM) düzeylerini azaltmaya yönelik basit bir bitkisel çürük önleme protokolünün etkinliğini değerlendirmektir. Gereç ve Yöntemler: Yapılan bu çalışmada Klorheksidin (CHX), meyan kökü ve serum fizyolojik kullanılmıştır. Toplam 90 hasta, her bir grup için 30 kişi olacak şekilde rastgele 3 gruba ayrıldı. Gargara öncesi, gargaradan 5 dk sonra ve gargaradan 1 saat sonrasında tükürük örnekleri toplanmıştır. Değerlendirmeler gargara sonrası 5 dk (T1), 1 saat sonra (T2) ve aradaki farklılıkları tespit amacıyla 5-60 dk (T3) olarak hesaplanmıştır. Ekimi yapılan örneklerin enkübasyon süresi sonunda plaklar değerlendirmeye alınarak üreyen kolonilerin colony forming Unit/mL (CFU mL-1) olarak sayımları yapılmıştır. CFU değerlerindeki azalmalar istatistiksel olarak analiz edildi. Elde edilen verilerin değerlendirilmesinde Kruskall-Wallis, Mann-Whitney U and Bonferroni düzeltmeli Friedman, Wilcoxon işaret ve testleri ile yapıldı ve yanılma düzeyi 0,05 olarak alındı. Bulgular: CHX, T1 ve T2 zamanları içerisinde istatistiksel olarak anlamlı düşüşler gösterirken (p0,05). Sonuç: Meyan kökü dental işlemlerde kullanılabilecek yararlı bir ajan olabilir ve meyan kökü oranının, içerisindeki glisirizik asit yüzdesinin ve tedavinin süresi ile ilgili daha ileri çalışmaların yapılması gerekmektedir.

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