Hazem M. Abu SHAWiSH, Hassan TAMOUS, Asma A. SHAHEEN, Khaled I. Abed ALMONEM, Ahmed Awad ELGAMEL, Wael S. AL-LHAM

Determination of haloperidol drug in ampoules and in urine samples using a potentiometric PVC-membrane and graphite coated wire electrodes

A new PVC membrane, called sensor P, and graphite coated wire, called sensor g, for haloperidol drug (HP) are described. The electrodes P and C exhibit a nernstian slope of 57.4±0.8 and 61.1±0.4 mV per decade over a wide concentration range from 3.7×10-6–1.0×10-2 mol/l and 5.8 x 10-7 – 1.0 x 10-2 mol/l and the limit of detection (loD) of 1.6 × 10-6 mol/l and 4.2×10-7 mol/l over the pH range of 2.5–7.5 and 2.5-8.0 respectively. The presented sensors show a very good selectivity for HP drug over the common interfering chemical species. The proposed electrodes were successfully used for determination of HP drug in ampoules and in urine samples with satisfactory results.

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