Selülitte Topikal Yaklaşımlar

Günümüzde özellikle kadınların büyük bölümünü etkileyen ve estetik bir sorun olan selülitin giderilmesi amacıyla farmakolojik aktif kimyasalların topikal uygulamaları ile fiziksel, mekanik ve termal yöntemlerin lokal uygulamaları mevcuttur. Selülite karşı etkili doğal veya sentetik kökenli aktif bileşenlerin selülit oluşan bölgelere topikal olarak uygulamasına yönelik birçok çalışma ve araştıma yapılmış ve de ürünler geliştirilmiştir. Selülite karşı geliştirilen formülasyonlar genellikle jel, emülsiyon, krem, losyon veya köpük formunda olup son yıllarda bu formülasyonlarda aktif bileşenlerin deriye penetrasyonunu arttırmak, aktivite gösterecekleri tabakalara ulaşmalarını sağlamak, salımını düzenlemek, stabilitelerini arttımak ve istenmeyen etkilerini azaltmak amacıyla farmasötik taşıyıcı sistemlerin kullanımı önem kazanmıştır. Taşıyıcı sistemlerden veziküler taşıyıcılar olan lipozomlar, fitozomlar, etozomlar ve nanozomların hem araştırmalarda hem de mevcut ürünlerde kullanımı dikkat çekmektedir. Selülit giderici ürünlerin performansını ölçmeye yönelik girişimsel olmayan aletli analiz yöntemleri mevcut olup bunlar ile hem araştırma-geliştirmede hem de mevcut ürünlerde etkinlik değerlendirmesi yapılabilmektedir. Selülit giderici topikal formülasyonların her geçen gün bilimsel ve teknolojik ilerlemeler doğrultusunda gelişeceği ve çeşitleneceği ilaveten uygulama ve maliyet avantajı sunmaları nedeniyle kullanımlarının yaygınlaşacağı düşünülmektedir.

Topical Approaches to Cellulite

Today, topical application of pharmacologically active chemicals and local application of physical, mechanical and thermal methods are available in order to eliminate cellulite which is an aesthetic problem that affects the majority of women. Many products on natural or synthetic originated anti-cellulite active ingredients have been developed with topical application studies performed on cellulite developed parts. Formulations developed against cellulite are usually in the form of gel, emulsion, cream, lotion or foam. In recent years the use of pharmaceutical delivery systems have become important in order to increase the penetration into the skin, to provide access to layers, to show activity, to regulate the release, to enhance the stability and to reduce the adverse effects of the active ingredients in these formulations. The use of liposomes, phytosomes, ethosomes and nanosomes which are the vesicular carriers of the carrier systems has drawn attention in both researches and existing products. Methods for measuring the performance of anti-cellulite products and efficacy evaluation for research and development of existing products are available with non-invasive device tool analysis. The use of anti-cellulite topical formulations has become widespread with cost advantages and it is expected that these formulations will develop and become diversified and spread more with both scientific and technological progress.

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