Zeynep SEVER ERDEM, Yasemin CAYİR, Zahide KOSAN, Haktan Bagis ERDEM

TEKRARLAYAN DÜŞÜK VE TAM KAN SAYIMI DEĞERLERİ ARASINDA HERHANGİ BİR İLİŞKİ VAR MI? BİR VAKA-KONTROL ÇALIŞMASI

AMAÇ:Tam kan sayımı değerleri ile tekrarlayan düşük arasındaki ilişkinin incelenmesi amaçlanmıştır.GEREÇ VE YÖNTEM:2010-2018 yılları arasında tekrarlayan düşük yapan hastalarda vaka-kontrol çalışması yaptık. Vaka grubunda dahil edilme kriterlerini karşılayan 50 hastanın verilerini, 60 kadından oluşan, en az bir canlı doğum yapmış aynı yaş grubundan kontrol grubu ile eşleştirdik. Tam kan sayımında kırmızı kan hücresi (RBC), hemoglobin (HB), hematokrit (HTC), ortalama korpüsküler hacim (MCV), ortalama korpüsküler hemoglobin (MCH), ortalama korpüsküler hemoglobin konsantrasyonu (MCHC), trombosit sayısı (PLT), trombosit dağılım genişliği (PDW), kan sayımında ortalama trombosit hacmi (MPV), kırmızı hücre dağılım genişliği (RDW) ve plateletkreit hesaplaması (PCT) incelendi. İstatistiksel analiz için SPSS 20.0.0 yazılımı kullanıldı. P<0,05 değeri istatistiksel olarak anlamlı kabul edildi.BULGULAR: Katılımcıların yaş ortalaması 29,08±5,5 yıldı. Vaka grubunda MPV ve RDW değerleri ile PCT hesaplaması sağlıklı kontrol grubundan anlamlı olarak yüksek bulundu (p<0,05). Vaka grubunun MCHC düzeyleri kontrol grubundan düşüktü (p<0,05). Vaka ve kontrol grubu arasında RBC, HB, HCT, MCV, MCH, PLT ve PDW açısından anlamlı bir fark yoktu (p>0,05).SONUÇLAR:Yüksek MPV, RDW, PCT ve düşük MCHC gibi tam kan sayımı parametreleri, tekrarlayan düşüklerin önemli bir belirleyicisi olarak düşünülebilir. Bulgularımız, bu kan hücresi fonksiyon belirteçleri ve tekrarlayan düşükler arasındaki ilişkiyi netleştirmek için daha fazla sayıda hasta içeren ileriye dönük çalışmalar ile desteklenmelidir.

Anahtar Kelimeler:

ortalama trombosit hacmi, tekrarlayan düşük

Is There Any Relation Between Recurrent Miscarriage and Complete Blood Count Values? A Case-Control Study

Objective: It was aimed to examine the relationship of complete blood count values with recurrent miscarriage.Method: We carried out a case-control study of patients who had recurrent miscarriage between 2010-2018. Data were collected from 50 patients who were meeting the case group inclusion criteria, and age-matched healthy control group with at least one live birth who consisted of 60 women. Red blood cell (RBC), hemoglobin (HB), hematocrit (HTC), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), platelet count (PLT), platelet distribution width (PDW), mean platelet volume (MPV), red cell distribution width (RDW) and plateletcrit count (PCT) were examined by complete blood count. SPSS 20.0.0 software was used for statistical analysis. P values <0.05 were regarded as statistically significant.Results: The mean age of the case group was 29.8±5.8 years, and the mean age of the control group was 28.7±5.2 years (p>0,05). MPV and RDW values and PCT calculations were significantly higher than healthy control group (p<0.05). MCHC levels of case group were lower than control group (p<0.05). There were no significant differences between the case and control groups in terms of RBC, HB, HCT, MCV, MCH, PLT, and PDW (p>0.05). Conclusion: Complete blood count parameters such as high MPV, RDW, PCT, and low MCHC could be considered as an important predictor of recurrent miscarriage. Our findings should be supported by further prospective studies involving a larger number of patients in order to clarify the relationship between these blood cell function markers and recurrent miscarriage.

Keywords:

mean platelet volume, recurrent miscarriage,

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ISSN: 1309-3878
Yayın Aralığı: Yılda 3 Sayı
Başlangıç: 2009
Yayıncı: Düzce Üniversitesi Tıp Fakültesi Aile Hekimliği AD adına Yrd.Doç.Dr.Cemil Işık Sönmez