Postpartum Dönemdeki Koyunlarda Oksitosin Uygulamasının Meme Arteri Doppler İndeksleri Üzerine Etkileri

Doğum sonrası uterus involüsyonunu hızlandırmak ve sütün indirilmesini sağlamak amacıyla sıklıkla uygulanan oksitosin hormonu vasküler tonusun düzenlenmesinde de etkilidir. Doppler ultrasonografi, doku ve organlara ait kan akımı özelliklerinin değerlendirilebilmesine olanak sağlayan oldukça pratik bir tekniktir. Bu çalışmada postpartum dönemdeki koyunlara uygulanan oksitosin hormonunun meme kan akımında oluşturduğu hemodinamik değişikliklerin incelenmesi amaçlandı. Çalışma tekiz kuzulamış olan 20 adet primipar Kıvırcık ırkı koyun ile gerçekleştirildi. Koyunlar randomize şekilde oksitosin ve kontrol gruplarına ayrıldı (her grup için n=10). Oksitosin ve kontrol gruplarına sırasıyla 10 IU/koyun dozda oksitosin ve 1 ml/koyun dozda serum fizyolojik doğum sonrası ilk üç gün boyunca günde 2 kez kas içi yoldan uygulandı. Puls Doppler ultrasonografi tekniği kullanılarak eksternal pudendal artere ait pulsatilite ve rezistans indeksleri (sırasıyla PI ve RI) ölçüldü. Oksitosin grubu daha yüksek PI ve RI değerlerine sahip olma eğiliminde olmasına karşın gruplar arasında anlamlı farklılık sadece birinci ve ikinci postpartum günlerin PI değerlerinde saptandı (sırasıyla p<0,001 ve p<0,05). Postpartum erken dönemdeki koyunlara uygulanan oksitosin hormonunun, meme arterinin direncini arttırdığı sonucuna ulaşıldı.

Anahtar Kelimeler:

Doppler ultrasonografi, Koyun, Oksitosin

Effects of Oxytocin Administration on Doppler Indices of Mammary Artery in Postpartum Ewes

Oxytocin hormone, which is frequently used in order to hasten uterine involution process and to ensure milk ejection, is also effective in regulation of vascular tone. Doppler ultrasonography is a highly practical technique that allows the evaluation of blood flow characteristics of tissues and organs. In this study, it was aimed to investigate the hemodynamic changes of mammary artery caused by oxytocin administration in postpartum ewes. The study was conducted with 20 primiparous Kivircik ewes which lambed singleton. The ewes were randomly divided into oxytocin and control groups (n=10 for each group). A dose of 10 IU/sheep oxytocin and 1 ml/sheep saline solution were administered intramuscularly bid on the first 3 days postpartum to oxytocin and control groups, respectively. The pulsed Doppler ultrasonography is used to measure pulsatility and resistance indices (PI and RI, respectively) of external pudendal artery. Although oxytocin group tended to have relatively higher PI and RI values, significant differences were detected only in PI values of the first and second days postpartum (p<0.001 and p<0.05, respectively) between groups. It has been concluded that oxytocin administration increased the resistance of mammary artery in early postpartum ewes.

Keywords:

Doppler ultrasonography, Oxytocin, Sheep,

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