Feline Panlökopeni Hastalarında Tedaviye Ek Koloni Stimüle Edici Faktör Kullanımının Kan Değerleri ve Prognostik Açıdan Önemi

Feline panlökopemi virüs özellikle genç ve aşısız bireylerde çok bulaşıcı seyreden, klasik tedaviler ile iyileşme oranları %50’nin altında olan, kedilerin önemli bir hastalığıdır. Bu çalışmada feline parvovirüs hastalarında klasik tedaviye ek olarak granülosit koloni sitümile edici faktör olarak filgrastim kullanımının prognostik başarısının incelenmesi amaçlanmıştır. Çalışmaya alınan 48 hastanın 31’inde filgrastim uygulaması yapılırken 17’si sadece klasik tedavi (kontrol grubu) yapılmıştır. Hastaların %93,61’inde lökopeni, %82,97’sinde ise nötropeni tespit edilmiştir. Hastaların %92,3’ünün aşısız olduğu görülmüştür. Filgrastim kullanılan grupta sağkalım %72,41 iken kontrol grubunda %58,82 dir ve aradaki fark istatistik yönden anlamsız bulunmuştur (p˃0,9999). Kontrol grubunun tedavi öncesi ve sonrası kan değerlerindeki değişim anlamsız bulunurken filgrastim grubunda tedavi öncesi WBC, LYM, NEU değerlerinin tedavi sonrası değişimi istatistik olarak önemli bulunmuştur (p˂0,001). Sonuç olarak feline parvovirüs hastalığından korunmada aşılamanın çok önemli olduğu, ilk muayenede ishal ve kusma gibi semptomların yanında lökopeninin dikkat çekici olduğu, tedavide klasik tedaviye ek olarak filgrastim kullanımının kan değerlerini yükselttiği ancak prognoza etkisinin olmadığı görülmüştür.

Anahtar Kelimeler:

Feline panlökopeni virus, Filgrastim, Lökopeni, Koloni sitümile edici faktör, Tedavi

The Effect of Granulocyte Colony Stimulating Factor Use in addition to Classical Treatment on Prognosis and Blood Values in Patients with Feline Panleukopenia

Feline panleukopenia virus is a notable disease in cats and has a very contagious progression especially in young and not vaccinated individuals. Worse still, conventional treatments have a below 50 % success rate in treating this disease. This study investigated the prognostic success of administering a granulocyte colony-stimulating factor, filgrastim, with the conventional treatment for cats with feline infectious enteritis. The study had 48 sick individuals, 31 of whom had conventional + filgrastim treatment, whereas 17 had only conventional treatment (control group). A ratio of 93.61 % of all individuals showed leukopenia and 82.97 % of all individuals had neutropenia. The ratio of not vaccinated individuals in the study sample was 92.3 %. The recovery ratio in the study group in which filgrastim was administered was 72.41 %, whereas this ratio was 58.82 % in the control group, yet the difference was not statistically significant (p˃0.9999). In the blood count values of the control group, there was no statistically significant difference between pre-treatment and post-treatment measurements. On the other hand, WBC, LYM, and NEU values were significantly different in the study group with additional filgrastim treatment (p<0.001). The study results indicated that vaccination is critical in protection against feline parvovirus, diarrhea, and vomiting symptoms in the first diagnosis are noteworthy, and using filgrastim in addition to the conventional treatment did not have a considerable impact on prognosis, although it did ameliorate blood values.

Keywords:

colony-stimulating factor, Feline panleukopenia Virus, Filgrastim, leukopenia, treatment,

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