İNSİDENTAL ADRENAL LEZYONLARIN KLİNİK, HORMONAL VE HİSTOLOJİK DEĞERLENDİRİLMESİ: TEK MERKEZ SONUÇLAR
AMAÇ: Adrenal insidentaloma günümüzde radyolojik görüntüleme yöntemlerinin yaygın kullanılmasıyla beraber klinikte sıkça karşılaştığımız bir problemdir. Bu çalışmada adrenal insidentaloma (Aİ) tanılı hastaların genel özelliklerinin değerlendirilmesi amaçlanmıştır. GEREÇ VE YÖNTEM: Çalışmada 2001-2013 yılları arasında Hacettepe Üniversitesi Tıp Fakültesi Hastanesi’nde Aİ tanısı alıp takip edilen hastaların klinik ve laboratuvar sonuçları retrospektif olarak incelenmiştir. BULGULAR: Çalışmaya 543 hasta dahil edildi. Hastaların 315 (%58)’ i kadın, 228 (%42)’ i erkekti (p
CLINICAL, HORMONAL AND HISTOLOGICAL EVALUATION OF INCIDENTAL ADRENAL LESIONS: SINGLE CENTER RESULTS
OBJECTIVE: Adrenal incidentaloma is a problem that is frequently encountered clinically with the widespread use of radiological imaging methods. In this study, it was aimed to evaluate the general characteristics of patients with adrenal incidentaloma (AI). MATERIAL AND METHODS: Clinical and laboratory results of the patients who were diagnosed and followed up at the Hacettepe University Medical Faculty Hospital between 2001 and 2013 were retrospectively analyzed. RESULTS: 543 patients were included in the study. 315 (58%) of the patients were female and 228 (42%) were male (p
___
1.Kloos RT, Gross MD, Francis IR, Korobkin M, Shapiro B. Incidentally discovered adrenal masses. Endocrine reviews. 1995; 16:460-484.2. Herrera MF, Grant CS, van Heerden JA, Sheedy PF, Ilstrup DM. Incidentally discovered adrenal tumors: an institutional perspective. Surgery. 1991; 110:1014-1021.
3. Bovio S, Cataldi A, Reimondo G, et al. Prevalence of adrenal incidentaloma in a contemporary computerized tomography series. J Endocrinol Invest. 2006; 29:298-302.
4. Young WF, Jr. Management approaches to adrenal incidentalomas. A view from Rochester, Minnesota. Endocrinol Metab Clin North Am. 2000; 29:159-185.
5. Mantero F, Terzolo M, Arnaldi G, et al. A survey on adrenal incidentaloma in Italy. Study Group on Adrenal Tumors of the Italian Society of Endocrinology. 2000; 85:637-644.
6. Belldegrun A, Hussain S, Seltzer SE, Loughlin KR, Gittes RF, Richie JP. Incidentally discovered mass of the adrenal gland. Surg Gynecol Obstet. 1986; 163:203-208.
7. Cho YY, Suh S, Joung JY, et al. Clinical characteristics and follow-up of Korean patients with adrenal incidentalomas. Korean J Intern Med. 2013; 28:557-564.
8. Haissaguerre M, Courel M, Caron P, et al. Normotensive incidentally discovered pheochromocytomas display specific biochemical, cellular, and molecular characteristics. J Clin Endocrinol Metab. 2013; 98(11):4346-54
9. Mitchell IC, Auchus RJ, Juneja K, et al. "Subclinical Cus hing's syndrome" is not subclinical: improvement after adrenalectomy in 9 patients. Surgery. 2007; 142:900-905.
10. Reincke M, Nieke J, Krestin GP, Saeger W, Allolio B, Winkelmann W. Preclinical Cushing's syndrome in adre nal "incidentalomas": comparison with adrenal Cushing's syndrome. J Clin Endocrinol Metab. 1992; 75:826-832.
11. Abdelmannan D, Aron DC. Adrenal incidentalomas and subclinical Cushing's syndrome. Rev Endocr Metab Disord. 2010; 11:135-140.
12. Tsuiki M, Tanabe A, Takagi S, Naruse M, Takano K. Car diovascular risks and their long-term clinical outcome in patients with subclinical Cushing's syndrome. Endocr J. 2008; 55:737-745.
13. Toniato A, Merante-Boschin I, Opocher G, Pelizzo MR, Schiavi F, Ballotta E. Surgical versus conservative mana gement for subclinical Cushing syndrome in adrenal inci dentalomas: a prospective randomized study. Ann Surg. 2009; 249:388-391.
14. Libe R, Dall'Asta C, Barbetta L, Baccarelli A, Beck-Pec coz P, Ambrosi B. Long-term follow-up study of patients with adrenal incidentalomas. Eur J Endocrinol. 2002; 147:489-494.
15. Terzolo M, Reimondo G, Angeli A. Definition of an op timal strategy to evaluate and follow-up adrenal inciden talomas: time for further research. Eur J Endocrinol. 2009; 161:529-532.
16. Vassilatou E, Vryonidou A, Michalopoulou S, et al. Hormonal activity of adrenal incidentalomas: results from a long-term follow-up study. Clin Endocrinol (Oxf). 2009; 70:674-679.
17. Nieman LK, Biller BM, Findling JW, Newell-Price J, Sa vage MO, Stewart PM, Montori VM. The diagnosis of Cus hing's syndrome: an Endocrine Society Clinical Practice Guideline. 2008; 93:1526-1540.
18. Funder JW, Carey RM, Fardella C, et al. Case detection, diagnosis, and treatment of patients with primary aldos teronism: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2008; 93:3266-3281.
19. Barzon L, Sonino N, Fallo F, Palu G, Boscaro M. Preva lence and natural history of adrenal incidentalomas. Eur J Endocrinol. 2003; 149:273-285.
20. Icard P, Goudet P, Charpenay C, et al. Adrenocortical carcinomas: surgical trends and results of a 253-patient series from the French Association of Endocrine Surgeo ns study group. World J Surg. 2001; 25:891-897.
21. Kasperlik-Zaluska AA, Migdalska BM, Makowska AM. Incidentally found adrenocortical carcinoma. A study of 21 patients. Eur J Cancer. 1998; 34:1721-1724.
22. Young WF, Jr. Clinical practice. The incidentally disco vered adrenal mass. The New England journal of medici ne. 2007; 356:601-610.
- ISSN: 1302-4612
- Yayın Aralığı: Yılda 4 Sayı
- Başlangıç: 1999
Sayıdaki Diğer Makaleler
F64A TARAFINDAN ALZHEİMER BENZERİ DEMANS OLUŞTURULAN RATLARDA BETAİN ve PİPERİNİN ETKİSİ
AYHAN VURMAZ, Fatih BOZKURT, Mine Dosay AKBULUT
İNSİDENTAL ADRENAL LEZYONLARIN KLİNİK, HORMONAL VE HİSTOLOJİK DEĞERLENDİRİLMESİ: TEK MERKEZ SONUÇLAR
Şafak AKIN, Selçuk DAĞDELEN, Okan Bülent YILDIZ, Alper GÜRLEK, Tomris ERBAŞ, Miyase BAYRAKTAR