Erdem TOPRAK, Efe ÖNEN, Sinan AVCI, Sedat ÖNER, Volkan ÇAĞLAYAN, Murat ŞAMBEL, Metin KILIÇ

Nötrofil-Lenfosit Oranı, Parsiyel Nefrektomi Öncesinde 4 cm'den Büyük Renal Kitlesi Olan Hastaların Patoloji Sonucunu Tahmin Etmekte Faydalıdır

GİRİŞ ve AMAÇ: Nötrofil-lenfosit oranının (NLR) parsiyel nefrektomi (PN) öncesi renal kitlelerin patoloji sonuçlarının öngörülmesindeki etkinliğini değerlendirmek.YÖNTEM ve GEREÇLER: Mart 2012 ve Mart 2018 tarihleri arasında PN yapılan 76 hastanın verileri değerlendirildi. Hastalar patoloji sonuçlarına (malign grup benign grup), tümör evresine (T1a-T1b) ve tümör derecesine (Grade 1-Grade2-Grade3) ve kitle boyutuna ( 4 cm) göre gruplandı.BULGULAR: Benign grup 17 hastadan, malign grup 59 hastadan oluşmaktaydı. Benign ve malign grupların preoperatif NLR'leri karşılaştırıldığında istatistiksel olarak anlamlı bir fark bulunmadı (p = 0.113). Malign grup tümör evresine göre (T1a-T1b) 2 gruba ayrıldığında, T1b grubunun NLR değeri benign grup ve T1a grubundan anlamlı olarak yüksekti (sırasıyla p= 0.007 ve p

Neutrophil-Lymphocyte Ratio is Valuable in Predicting the Pathology Result in the Patients with Renal Mass > 4 cm Prior to the Partial Nephrectomy

INTRODUCTION: To assess the efficacy of neutrophillymphocyte ratio (NLR) in predicting the pathology results of renal masses prior to partial nephrectomy (PN).METHODS: The data of 76 patients who underwent PNbetween March 2012 and March 2018 was evaluated. Patientswere grouped according to pathology results (malign groupbenign group), tumor stage (T1a-T1b) and tumor grade (Grade1-Grade2-Grade3) and mass size (≤4 cm->4 cm).RESULTS: Benign group was consisted of 17 patients andmalign group was of 59 patients. No statistically significantdifference was found when preoperative NLR of benign andmalign groups were compared (p=0.113). When malign groupwas divided into 2 groups according to tumor stage (T1a-T1b),NLR of T1b group was significantly higher than benign group and T1a group (p=0.007 and p4 cm malign renal masses (p=0.035). The cut-off value to predict malignancy was 2.31 with 65% specificity and 50% sensitivity.DISCUSSION and CONCLUSION: NLR is a valuable parameter at predicting pathology result in patients with renal masses >4 cm. Higher NLR value was associated high grade tumors. Further studies must be performed to certify theefficacy of NLR.

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