Neutrophil-Lymphocyte Ratio is Valuable in Predicting the Pathology Result in the Patients with Renal Mass > 4 cm Prior to the Partial Nephrectomy

INTRODUCTION: To assess the efficacy of neutrophillymphocyte ratio (NLR) in predicting the pathology results of renal masses prior to partial nephrectomy (PN). METHODS: The data of 76 patients who underwent PN between March 2012 and March 2018 was evaluated. Patients were grouped according to pathology results (malign groupbenign group), tumor stage (T1a-T1b) and tumor grade (Grade1-Grade2-Grade3) and mass size (≤4 cm->4 cm). RESULTS: Benign group was consisted of 17 patients and malign group was of 59 patients. No statistically significant difference was found when preoperative NLR of benign and malign groups were compared (p=0.113). When malign group was divided into 2 groups according to tumor stage (T1a-T1b), NLR of T1b group was significantly higher than benign group and T1a group (p=0.007 and p4 cm malign renal masses (p=0.035). The cut-off value to predict malignancy was 2.31 with 65% specificity and 50% sensitivity. DISCUSSION and CONCLUSION: NLR is a valuable parameter at predicting pathology result in patients with renal masses >4 cm. Higher NLR value was associated high grade tumors. Further studies must be performed to certify the efficacy of NLR.

Nötrofil-Lenfosit Oranı, Parsiyel Nefrektomi Öncesinde 4 cm'den Büyük Renal Kitlesi Olan Hastaların Patoloji Sonucunu Tahmin Etmekte Faydalıdır

GİRİŞ ve AMAÇ: Nötrofil-lenfosit oranının (NLR) parsiyel nefrektomi (PN) öncesi renal kitlelerin patoloji sonuçlarının öngörülmesindeki etkinliğini değerlendirmek. YÖNTEM ve GEREÇLER: Mart 2012 ve Mart 2018 tarihleri arasında PN yapılan 76 hastanın verileri değerlendirildi. Hastalar patoloji sonuçlarına (malign grup benign grup), tümör evresine (T1a-T1b) ve tümör derecesine (Grade 1-Grade2-Grade3) ve kitle boyutuna ( 4 cm) göre gruplandı. BULGULAR: Benign grup 17 hastadan, malign grup 59 hastadan oluşmaktaydı. Benign ve malign grupların preoperatif NLR'leri karşılaştırıldığında istatistiksel olarak anlamlı bir fark bulunmadı (p = 0.113). Malign grup tümör evresine göre (T1a-T1b) 2 gruba ayrıldığında, T1b grubunun NLR değeri benign grup ve T1a grubundan anlamlı olarak yüksekti (sırasıyla p= 0.007 ve p

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1. Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F. Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 2015;136:359–86.

2. Gupta K, Miller JD, Li JZ, Russell MW, Charbonneau C. Epidemiologic and socioeconomic burden of metastatic renal cell carcinoma (mRCC): a literature review. Cancer Treat Rev 2008;34(3):193– 205.

3. Levi F, Ferlay J, Galeone C, Lucchini F, Negri E, Boyle P, La Vecchia C. The changing pattern of kidney cancer incidence and mortality in Europe. BJU Int. 2008;101(8):949-58.

4. Patard JJ, Rodriguez A, Rioux-Leclercq N, Guillé F, Lobel B. Prognostic significance of the mode of detection in renal tumours. BJU Int. 2002;90(4):358-63.

5. Kato M, Suzuki T, Suzuki Y, Terasawa Y, Sasano H, Arai Y. Natural history of small renal cell carcinoma: evaluation of growth rate, histological grade, cell proliferation and apoptosis. J Urol. 2004;172(3):863-6.

6. Tsui KH, Shvarts O, Smith RB, Figlin R, de Kernion JB, Belldegrun A. Renal cell carcinoma: prognostic significance of incidentally detected tumors. J Urol. 2000;163(2):426-30.

7. Cumberbatch MG, Rota M, Catto JW, La Vecchia C. The Role of Tobacco Smoke in Bladder and Kidney Carcinogenesis: A Comparison of Exposures and Meta-analysis of Incidence and Mortality Risks. Eur Urol. 2016;70(3):458-66.

8. Thompson RH, Boorjian SA, Lohse CM, Leibovich BC, Kwon ED, Cheville JC, Blute ML. Radical nephrectomy for pT1a renal masses may be associated with decreased overall survival compared with partial nephrectomy. J Urol. 2008;179(2):468- 71.

9. Huang WC, Elkin EB, Levey AS, Jang TL, Russo P. Partial nephrectomy versus radical nephrectomy in patients with small renal tumors--is there a difference in mortality and cardiovascular outcomes? J Urol. 2009;181(1):55-61.

10. Miller DC, Schonlau M, Litwin MS, Lai J, Saigal CS. Renal and cardiovascular morbidity after partial or radical nephrectomy. Cancer. 2008;112(3):511-20.

11. Israel GM, Bosniak MA. An update of the Bosniak renal cyst classification system. Urology 2005;66:484–8.

12. Jinzaki M, Tanimoto A, Narimatsu Y, Ohkuma K, Kurata T, Shinmoto H, Hiramatsu K, Mukai M, Murai M. Angiomyolipoma: imaging findings in lesions with minimal fat. Radiology 1997;205: 497–502.

13. Sant GR, Ayers DK, Bankoff MS, Mitcheson HD, Ucci AA Jr. Fine needle aspiration biopsy in the diagnosis of renal angiomyolipoma. J Urol 1990;143:999–1001.

14. Mullins JK, Feng T, Pierorazio PM, Patel HD, Hyams ES, Allaf ME. Comparative analysis of minimally invasive partial nephrectomy techniques in the treatment of localized renal tumors. Urology 2012; 80: 316–21.

15. Kutikov A, Fossett LK, Ramchandani P, Tomaszewski JE, Siegelman ES, Banner MP, Van Arsdalen KN, Wein AJ, Malkowicz SB. Incidence of benign pathologic findings at partial nephrectomy for solitary renal mass presumed to be renal cell carcinoma on preoperative imaging. Urology 2006; 68: 737–40.

16. Coussens LM, Werb Z. Inflammation and cancer. Nature. 2002;420:860-7.

17. Mantovani A, Allavena P, Sica A, Balkwill F. Cancer-related inflammation. Nature. 2008;454:436-44.

18. Luo Y, She DL, Xiong H, Fu SJ, Yang L. Pretreatment neutrophil to lymphocyte ratio as a prognostic predictor of urologic tumors: a systematic review and meta-analysis. Medicine (Baltimore). 2015;94(40):e1670

19. Templeton AJ, Ace O, McNamara MG, AlMubarak M, Vera-Badillo FE, Hermanns T, Seruga B, Ocaña A, Tannock IF, Amir E. Prognostic role of platelet to lymphocyte ratio in solid tumors: a systematic review and meta-analysis. Cancer Epidemiol Biomarkers Prev. 2014;23(7):1204-12.

20. Templeton AJ, McNamara MG, Šeruga B, Vera-Badillo FE, Aneja P, Ocaña A, Leibowitz-Amit R, Sonpavde G, Knox JJ, Tran B, Tannock IF, Amir E. Prognostic role of neutrophil-to-lymphocyte ratio in solid tumors: a systematic review and metaanalysis. J Natl Cancer Inst. 2014;106(6):dju124

21. Petrie HT, Klassen LW, Kay HD. Inhibition of human cytotoxic T lymphocyte activity in vitro by autologous peripheral blood granulocytes. J Immunol. 1985;134(1):230-4.

22. Ohno Y, Nakashima J, Ohori M, Hatano T, Tachibana M. Pretreatment neutrophil-to lymphocyte ratio as an independent predictor of recurrence in patients with nonmetastatic renal cell carcinoma. J Urol. 2010;184(3):873–8.

23. de Martino M, Pantuck AJ, Hofbauer S, Waldert M, Shariat SF, Belldegrun AS, Klatte T. Prognostic impact of preoperative neutrophil-tolymphocyte ratio in localized nonclear cell renal cell carcinoma. J Urol. 2013;190(6):1999–2004.

24. Viers BR, Thompson RH, Lohse CM, Cheville JC, Leibovich BC, Boorjian SA, Tollefson MK. Pre-treatment neutrophil-to-lymphocyte ratio predicts tumor pathology in newly diagnosed renal tumors. World J Urol. 2016;34(12):1693-9.

25. Bazzi WM, Dejbakhsh SZ, Bernstein M, Russo P. Neutrophil-lymphocyte ratio in small renal masses. ISRN Urol. 2014;2014:759253.

26. Widz D, Mitura P, Buraczyński P, Płaza P, Bar M, Cabanek M, Nowak G, Ostrowska A, Bar K. Preoperative neutrophil-lymphocyte ratio as a predictor of overall survival in patients with localized renal cell carcinoma. Urol J. 2019 May 13. doi: 10.22037/uj.v0i0.4541. [Epub ahead of print]

27. Kisa E, Yucel C, Keskin MZ, Karabicak M, Yalcin MY, Cakmak O, Ilbey YO. The Role of Hematological Parameters in Predicting Fuhrman Grade and Tumor Stage in Renal Cell Carcinoma Patients Undergoing Nephrectomy. Medicina (Kaunas). 2019 Jun 18;55(6). pii: E287.

28. Gorgel SN, Ozer K, Kose O, Dindar AS. Can preoperative neutrophil lymphocyte ratio predict malignancy in patients undergoing partial nephrectomy because of renal mass? Int Braz J Urol. 2018;44(3):461-6.
Kocaeli Tıp Dergisi-Cover
  • ISSN: 2147-0758
  • Başlangıç: 2012
  • Yayıncı: -
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