Mustafa DOĞUŞ, FETHİ YAVUZ, Mehmet KÜÇÜKOSMANOĞLU, Arafat YILDIRIM, Salih KILIÇ

Epicardial Adipose Tissue Thickness and Its Relationship With The Pathophysiology of Saphenous Vein Graft Disease

INTRODUCTION: Despite technical and medical advances, SVGD remains a significant problem that is associated with high morbidity and mortality rates. EAT communicates locally with coronary vessels and myocardium through paracrine or vasocrine pathways. Although the relationship between EAT and CAD is well known, there is not sufficient information about effect of EAT on SVGD. Therefore, we aimed to investigate the relationship between EAT and SVGD. METHODS: The study population consisted of 124 consecutive patients who underwent elective CAG more than one year after CABG surgery. The patients were divided into two groups depending on the extent of SVG patency. EAT thickness measurements were determined from the low echogenic density area perpendicular to lines drawn from the parasternal long and short axes to the free wall of the right ventricle. RESULTS: EAT thickness was significantly higher in the SVGD (+) group than in the SVGD (-) group (p < 0.001). The multivariate logistic regression models revealed that EAT thickness (p < 0.001, Odds ratio (OR) = 3.65, 95% Confidence interval (C.I.) = 2.52–8.12) was found to be independent factor for predicting SVG stenosis. An EAT thickness value of > 7.4 mm has 86.4 % sensitivity, 69.1 % specificity for the prediction of SVG stenosis. DISCUSSION AND CONCLUSION: EAT thickness is related to the presence of SVG stenosis. EAT thickness therefore could serve as an easily measurable non-invasive adjunctive marker to classical risk factors for the prediction of SVG stenosis.

Epikardiyal Yağ Dokusu Kalınlığı ve Safen Ven Greft Hastalığının Patofizyolojisi ile İlişkisi

GİRİŞ ve AMAÇ: Teknik ve tıbbi ilerlemelere rağmen SVGH, yüksek morbidite ve mortalite oranları ile önemli bir sorun olmaya devam etmektedir. EYD, parakrin veya vazokrin yolaklar ile lokal olarak koroner damarlar ve miyokard ile iletişim kurar. EYD ve KAH arasındaki ilişki iyi bilinmesine rağmen, EYD'nin SVGH üzerindeki etkisi hakkında yeterli bilgi yoktur. Bu nedenle EYD ve SVGH arasındaki ilişkiyi araştırmayı amaçladık. YÖNTEM ve GEREÇLER: Çalışma popülasyonu, KABG cerrahisinden bir yıldan fazla bir süre sonra elektif KAG uygulanan 124 ardışık hastadan oluşmaktaydı. Hastalar SVG açıklığının derecesine göre iki gruba ayrıldı. EYD kalınlığı ölçümleri, parasternal uzun ve kısa eksenlerden sağ ventrikülün serbest duvarına çizilen çizgilere dik olan düşük ekojenik yoğunluk alanından belirlendi. BULGULAR: EYD kalınlığı SVGH (+) grubunda SVGH (-) grubuna göre anlamlı olarak daha yüksekti (p

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