INTRODUCTION: Hemogram parameters are considered as inflammatory markers in various diseases. The objective of this study was to assess mean platelet volume to lymphocyte ratio (MPVLR) of subjects with IBS and to compare to those in healthy population. METHODS: Patients with IBS whose admissions to our outpatient internal medicine clinic were enrolled to the study. Patients with IBS were divided into two groups according to the predominant symptom, either IBS diarrhea predominant (IBS-D) or IBS constipation predominant (IBS-C). Healthy volunteers were enrolled as control group. General characteristics and MPVLR levels of the groups compared. RESULTS: The MPVLR of IBS-C, IBS-D and control groups were 0.005 (0.001), 0.004 (0.001) and 0.003 (0.001), respectively (p
GİRİŞ ve AMAÇ: Hemogram parametreleri birçok çalışmada inflamatuvar belirteç olarak kullanılmaktadır. Bu çalışmamızdaki amacımız İBS ve sağlıklı kontrollerdeki ortalama trombosit hacmi/lenfosit oranının (MPVLR) karşılaştırılmasıdır. YÖNTEM ve GEREÇLER: İç hastalıkları polikliniğimize başvuran İBS’li hastalar çalışmamıza alındı. İBS’li hastalar diyare predominat İBS (IBS-D) ve konstipasyon predominant İBS (IBS-C) olarak iki ana gruba ayrıldı. Sağlıklı kişilerden de kontrol grubu oluşturuldu. Çalışmamızda grupların genel özellikleri ve MPVLR seviyeleri karşılaştırıldı. BULGULAR: IBS-C, IBS-D ve kontrol gruplardaki MPVLR sırasıyla; 0.005 (0.001), 0.004 (0.001) ve 0.003 (0.001), (p
___
1. Mearin F, Lacy BE, Chang L, Chey WD, Lembo AJ, Simren M, et al. Bowel Disorders. Gastroenterology. 2016.
2. Camilleri M, Katzka DA. Irritable bowel syndrome: methods, mechanisms, and pathophysiology. Genetic epidemiology and pharmacogenetics in irritable bowel syndrome. American journal of physiology Gastrointest Liver Physiol. 2012;302(10):G1075-84.
3. Park Y, Schoene N, Harris W. Mean platelet volume as an indicator of platelet activation: methodological issues. Platelets. 2002;13(5- 6):301-6.
4. Gasparyan AY, Stavropoulos-Kalinoglou A, Toms TE, Douglas KM, Kitas GD. Association of mean platelet volume with hypertension in rheumatoid arthritis. Inflam Allergy Drug Targets. 2010;9(1):45-50.
5. Aktas G, Kocak MZ, Duman TT, Erkus E, Atak BM, Sit M, et al. Mean Platelet Volume (MPV) as an inflammatory marker in type 2 diabetes mellitus and obesity. Bali Med J. 2018;7(3):650-3.
6. Karagoz I, Aktas G, Yoldas H, Yildiz I, Ogun MN, Bilgi M, et al. Association Between Hemogram Parameters and Survival of Critically Ill Patients. J Intensive Care Med. 2019;34(6):511-3.
7. Ha S-I, Choi D-H, Ki Y-J, Yang J-S, Park G, Chung J-W, et al. Stroke prediction using mean platelet volume in patients with atrial fibrillation. Platelets. 2011;22(6):408-14.
8. Dagistan Y, Dagistan E, Gezici AR, Halicioglu S, Akar S, Ozkan N, et al. Could red cell distribution width and mean platelet volume be a predictor for lumbar disc hernias? Ideggyogy Sz. 2016;69(11-12):411-4.
9. Kapsoritakis AN, Koukourakis MI, Sfiridaki A, Potamianos SP, Kosmadaki MG, Koutroubakis IE, et al. Mean platelet volume: a useful marker of inflammatory bowel disease activity. Am J Gastroenterol. 2001;96(3):776-81.
10. Cakir L, Aktas G, Enginyurt O, Cakir SA. Mean platelet volume increases in type 2 diabetes mellitus independent of HbA1c level. Acta Med Mediterranea. 2014;30(2):425-8.
11. Choi CU, Seo HS, Kim YK, Na JO, Lim HE, Kim JW, et al. Can mean platelet volume predict coronary vasospasm? Platelets. 2011;22(3):173-8.
12. Aktas G, Cakiroglu B, Sit M, Uyeturk U, Alcelik A, Savli H, et al. Mean platelet volume: a simple indicator of chronic prostatitis. Acta Med Mediterranea. 2013;29:551-4.
13. Sit M, Aktaş G, Yilmaz EE, Hakyemez IN, Alçelik A, Küçükbayrak A. Platelet parameters in hepatic hydatid cysts. Int J Inflam. 2013;2013.
14. Erkus E, Aktas G, Atak BM, Kocak MZ, Duman TT, Savli H. Haemogram Parameters in Vitamin D Deficiency. J Coll Physicians Surg Pak. 2018;28(10):779-82.
15. Sincer I, Gunes Y, Mansiroglu AK, Cosgun M, Aktas G. Association of mean platelet volume and red blood cell distribution width with coronary collateral development in stable coronary artery disease. Postepy Kardiol Interwencyjnej. 2018;14(3):263-9.
16. Aktas G, Alcelik A, Tekce BK, Tekelioglu V, Sit M, Savli H. Red cell distribution width and mean platelet volume in patients with irritable bowel syndrome. Prz Gastroenterol. 2014;9(3):160-3.
17. Aktas G, Sit M, Tekce H, Alcelik A, Savli H, Simsek T, et al. Mean platelet volume in nasal polyps. West Ind Med J. 2013;62(6):515-8.
18. Kocak MZ, Aktas G, Erkus E, Duman TT, Atak BM, Savli H. Mean Platelet Volume to Lymphocyte Ratio as a Novel Marker for Diabetic Nephropathy. J Coll Physicians Surg Pak. 2018;28(11):844-7.
19. Imtiaz F, Shafique K, Mirza SS, Ayoob Z, Vart P, Rao S. Neutrophil lymphocyte ratio as a measure of systemic inflammation in prevalent chronic diseases in Asian population. Int Arch Med. 2012;5(1):2.
20. Allavena P, Sica A, Solinas G, Porta C, Mantovani A. The inflammatory microenvironment in tumor progression: the role of tumor-associated macrophages. Crit Rev Oncol Hematol. 2008;66(1):1-9.
21. Ornek E, Kurtul A. Relationship of mean platelet volume to lymphocyte ratio and coronary collateral circulation in patients with stable angina pectoris. Cor Artery Dis. 2017;28(6):492-7.
22. Hudzik B, Szkodziński J, Lekston A, Gierlotka M, Poloński L, Gąsior M. Mean platelet volume-to-lymphocyte ratio: a novel marker of poor short-and long-term prognosis in patients with diabetes mellitus and acute myocardial infarction. J Diabetes Complications. 2016;30(6):1097-102.
23. Tasoglu O, Sahin A, Karatas G, Koyuncu E, Tasoglu I, Tecimel O, et al. Blood mean platelet volume and platelet lymphocyte ratio as new predictors of hip osteoarthritis severity. Medicine. 2017;96(6):e6073.
24. Kurtul A, Acikgoz SK. Usefulness of Mean Platelet Volume-to-Lymphocyte Ratio for Predicting Angiographic No-Reflow and ShortTerm Prognosis After Primary Percutaneous Coronary Intervention in Patients With STSegment Elevation Myocardial Infarction. Am J Cardiol. 2017;120(4):534-41.
25. Bozlu G, Karpuz D, Hallioglu O, Unal S, Kuyucu N. Relationship between mean platelet volume-to-lymphocyte ratio and coronary artery abnormalities in Kawasaki disease. Cardiol Young. 2018;28(6):832-6.