Cihangir ÇAKIR, Hatice KAYA ÖZDEN, Erkan ŞENGÜL

Hemodiyaliz Hastalarında Nötrofil/Lenfosit Oranı ile Kaşıntı Arasındaki İlişki

GİRİŞ ve AMAÇ: Kaşıntı, hemodiyaliz hastalarında en sık karşılaşılan kutanöz problem olup yaşam kalitesini etkileyen önemli bir semptomdur. Kaşıntının önemli bir nedeni inflamasyondur. Kronik hastalıklarda nötrofil/lenfosit oranı inflamatuar bir belirteç olarak kullanılmaktadır. Biz de hemodiyaliz hastalarında nötrofil/lenfosit oranı ile kaşıntı arasında ilişki olup olmadığını araştırmayı amaçladık. YÖNTEM ve GEREÇLER: En az 3 ay süre ile rutin hemodiyalize giren 80 hasta (45 erkek, 35 kadın) ve 80 sağlıklı kontrol (35 erkek,45 kadın) grubu çalışmaya alındı. Hastaların biyokimyasal ve hematolojik değişkenleri kaydedildi, kaşıntısı sorgulandı ve dermatolojik muayeneleri yapıldı. Kontrol grubu ise check-up amaçlı dahiliye polikliniğine başvuru yapan, sağlıklı gönüllülerden oluşturuldu. Verilerin analizi SPSS 25 programında gerçekleştirildi. BULGULAR: Çalışmaya dahil edilen hasta ve kontrol grubunun yaşortalaması sırası ile 59±14.44 ve 57.61±14.29 yıl idi. Hastaların % 70’inde (n=56) kaşıntı yok iken, % 18’inde (n=14) lokalize kaşıntı ve % 12’sinde (n=10) yaygın kaşıntı saptandı. Bu hastaların 20’sinde (% 25) kaşıntı epizodik özellikte iken 4’ünde (%5) persistan idi. Hasta grubunda kontrol grubuna göre nötrofil/lenfosit oranı ve platelet/lenfosit oranıanlamlı olarak daha yüksek saptandı (sırası ile p

The Relationship between Neutrophil/Lymphocyte Ratio and Pruritus in Hemodialysis Patients

INTRODUCTION: Pruritus is themostcommon skin problem in hemodialysispatientsand is an importantsymptomaffectingquality of life. An importantcause of pruritus is inflammation. Neutrophil/lymphocyteratio is used as an inflammatory marker in chronicdiseases. Weaimedtoinvestigatewhetherthere is anyrelationshipbetweenitchingandneutrophil/ lymphocyteratio in hemodialysispatients. METHODS: Eighty patients (45 males, 35 females) and 80 healthycontrols (35 males, 45 females) undergoingroutinehemodialysisfor at least 3 monthswereincluded in thestudy. Biochemicalandhematologicalvariables of thepatientswererecorded, itchingwasdeterminedanddermatologicalexaminationswereperformed. Thecontrolgroupwasconsisted of healthyvolunteerswhoappliedtothedepartment of internalmedicineforthecheck-up. Data wereanalyzedby SPSS 25 program. RESULTS: Themeanage of thepatientsandcontrolswere 59±14.44 and 57.61±14.29 years, respectively. While 70% (n=56) of thepatients had nopruritus, 18% (n=14) had localizeditchingand 12% (n=10) had itching. Itchingwasepisodic in 20 (25%) of thesepatientsandpersistent in 4 (5%). Neutrophil/lymphocyteratioandplatelet/lymphocyteratioweresignifican tlyhigher in thepatientgroupthanthecontrolgroup (p

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