Nur YÜCEL EKİCİ

Alerjik riniti olan çocuklarda alerji ve hematolojik parametreler arasında bir korelasyon var mı?

GİRİŞ ve AMAÇ: Alerjik rinitte (AR) hematolojik parametrelerin önemi ile ilgili literatür bilgisi net değildir. Bu çalışmanın amacı hematolojik parametrelerin çocuklarda allerjik rinitin tanı ve şiddetiyle ilişkisini ve prediktif değerlerini değerlendirmektir. YÖNTEM ve GEREÇLER: ARIA kılavuzuna göre AR tanısı alan 136 çocuğun klinik kayıtları retrospektif olarak incelendi. Çalışmaya allerjik rinit kanıtı olmayan 60 çocuk kontrol grubu olarak dahil edildi. Total immünoglobulin E düzeyleri, deri prick testleri ve tam kan sayımı değerlendirildi. AR olan çocuklar AR şiddetine göre hafif grup (grup 1) ve orta / şiddetli grup (grup 2) olarak gruplandırıldı. BULGULAR: Eozinofil sayısı (EC), eozinofil yüzdesi (E%) ve eozinofil -lenfosit oranı (ELR) çalışma grubunda kontrol grubuna göre anlamlı olarak daha yüksekti (p

Is there any correlation between allergy and hematological parameters in children with allergic rhinitis?

INTRODUCTION: The importance of hematological parameters in allergic rhinitis (AR) was confusing in the literature. The aim of this study was to evaluate the association and predictive value of hematological parameters with the diagnosis and severity of allergic rhinitis in children.METHODS: The clinical records of 136 children who were diagnosed with AR according to the ARIA guideline were reviewed retrospectively. 60 children with no evidence of allergic rhinitis were included the study as control group. The total immunoglobulin E levels, skin prick tests and complete blood count were assessed. The children with AR were grouped as mild group (group 1) and moderate / severe group (group 2)according to severity of AR.RESULTS: Eosinophil count (EC), percentage of eosinophils (E%) and also eosinophil to lymphocyte ratio (ELR) in study group was significantly higher than control group (p

PDF

___

1- Bousquet J, Khaltaev N, Cruz AA, Denburg J, Fokkens WJ, Togias A, et al. World Health Organization; GA(2)LEN; AllerGen. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen). Allergy 2008;86:8-160.
2- Heinzerling L, Mari A, Bergmann KC, Bresciani M, Burbach G, Darsow U, et al. The skin prick test - European standards. Clin Transl Allergy 2013;3:3.
3- Plebani M. Clinical value and measurement of specific IgE. Clin Biochem 2003;36:453-69.
4- Li Y, Wu R, Tian Y, Bao T, Tian Z. The correlation of serum eosinophil cationic protein level with eosinophil count, and total IgE level in Korean adult allergic rhinitis patients. Asian Pac J Allergy Immunol 2016;34:33-37.
5- Chen ST, Sun HL, Lu KH, Lue KH, Chou MC. Correlation of immunoglobulin E, eosinophil cationic protein, and eosinophil count with the severity of childhood perennial allergic rhinitis. J Microbiol Immunol Infect 2006;39:212-8.
6- Jung YG, Kim KH, Kim HY, Dhong HJ, Chung SK. Predictive capabilities of serum eosinophil cationic protein, percentage of eosinophils and total immunoglobulin E in allergic rhinitis without bronchial asthma. J Int Med Res 2011;39:2209-16.
7- Kuehr J, Frischer T, Barth R, Karmaus W, Krüger S, Meinert R, et al. Eosinophils and eosinophil cationic protein in children with and without sensitization to inhalant allergens. Eur J Pediatr 1994;153:739-44.
8- Yenigun A, Sezen S, Calim OF, Ozturan O. Evaluation of the eosinophil-to-lymphocyte ratio in pediatric patients with allergic rhinitis. Am J Rhinol Allergy 2016;30:21-5.
9- Bakshi SS. Commentary to: ‘Is neutrophillymphocyte ratio associated with the severity of allergic rhinitis in children?' Eur Arch Otorhinolaryngol 2016;273:3447-8.
10- Doğru M, Evcimik MF, Cirik AA. Is neutrophil – lymphocyte ratio associated with the severity of allergic rhinitis in children? Eur Arch Otorhinolaryngol 2016;273:3175-8.
11- Bousquet J, Anto JM, Bachert C, Bousquet PJ, Colombo P, Crameri R, et al. Factors responsible for differences between asymptomatic subjects and patients presenting an IgE sensitization to allergens. A GA2LEN project. Allergy 2006;61:671-80.