AçıkKalpCerrahisi SonrasıGelişenDerinSternal Enfeksiyonların TedavisindeVakumYardımlıKapamaYöntemininEtkinliği

GİRİŞ ve AMAÇ: Bu çalışma, kardiyak cerrahi sonrası gelişen derin sternal yara enfeksiyonlarında konvansiyonel tedavi yöntemleriyle vakum yardımlı kapama tedavi yönteminin uygulandığı hastaların ölüm, reenfeksiyon ve hastanede kalış sürelerini karşılaştırmak için tasarlanmıştır. YÖNTEM ve GEREÇLER: Çalışmaya Kasım 2006-Haziran 2014 tarihleri arasında aynı merkezde açık kalp cerrahisi sonrası derin sternal yara enfeksiyon tanısıyla tedavi uygulanan 72 hasta dâhil edildi. Hasta verileri retrospektif olarak incelendi. Konvansiyonel yara bakımı ve pansuman yöntemleriyle tedavi uygulanan hastalar Grup 1(n=38), vakum yardımlı kapama yöntemiyle tedavi uygulanan hastalar ise Grup 2(n=34) olarak sınıflandırıldı. BULGULAR: Hastaların 25'i kadın olup yaş ortalaması 65,3±7,8 yıldı. Tedavinin 7.gününde bakılan ortalama C-reaktif protein(p=0.02), ortalama lökosit sayısı(p=0.01) ve ortalama eritrosit sedimantasyon hızı(p=0.005) değerleri açısından gruplar arasında anlamlı fark mevcuttu. Tedavinin 10.günü alınan mediastinal veya sternal yara akıntı kültüründe Grup 1'de 26 hastada(68,4%), Grup 2'de ise 5 hastada(14,7%) mikroorganizma üremesi mevcuttu(p=0.0001). Doksan günlük mortalite Grup 1'de gelişmezken Grup 2'de ise 6 hasta(%15,8)'da gelişti(p=0.03). Sağ kalan hastaların hastanede kalış süreleri Grup 1'de ortalama 23,3±5,5 gün iken Grup 2'de ise 17,3±3,4 gündü(p=0.0001). TARTIŞMA ve SONUÇ: Açık kalp cerrahisi sonrası gelişen derin sternal yara enfeksiyonların tedavisinde vakum yardımlı kapama yöntemi konvansiyonel tedavi yöntemlerine göre yara iyileşmesini hızlandıran, hastanede kalış süresini kısaltan ve yara yerindeki mikroorganizmaların daha erken eradikasyonunu sağlayan güvenli ve etkili bir yöntemdir.

TheEfficiencyofVacuumAssistedClosureMethodforTreatmentofDeep SternalInfectionsFollowingOpenCardiacSurgery

INTRODUCTION: In this study, we aimed to compare the conventional treatment methods with vacuum assisted closure treatment technique for mortality, re-infection and duration of hospitalization in patients who had deep sternal wound infection after cardiac surgery. METHODS: Seventy two patients who had deep sternal infection after open heart surgery between November 2006-June 2014 were enrolled in the study. The data were collected retrospectively. The patients who were treated with conventional wound care were enrolled in group 1(n=38), the patients who were treated with vacuum assisted closure were enrolled in group 2 (n=34). RESULTS: Twenty five of the patients were female and the mean age of the patients were 65,3±7,8 years. The mean values of C-reactive protein(p=0.02), leukocyte counts(p=0.01) and erythrocyte sedimentation rate (p=0.005) were significantly different between the groups. The incubation of sternal and mediastinal swap at 10 days were positive in 26 patients in group 1(68,4%), and positive in 5 patients in group 2(14,7%)(p=0.0001). The 90-days mortality; no mortality was observed in group 1, and 6 of patients(%15,8) died in group 2 (p=0.03). The duration of hospitalization in survived patients were 23,3±5,5 days in group 1 and were 17,3±3,4 days in group 2 (p=0.0001). DISCUSSION AND CONCLUSION: The patients who were treated with vacuum assisted closure when compared to conventional wound care, for deep sternal wound infection after cardiac surgery, were associated with shortened hospital stay, accelerate in wound healing and eradication of microorganisms.

___

  • 1.Joseph L, Jeanmonod RK. Delayed presentation of deep sternal wound infection. West J Emerg Med. 2014;15:134-6.
  • 2.Toumpoulis IK, Anagnostopoulos CE, DeRose JJ. Impact of deep sternal wound infection on long term survival after coronary artery bypass grafting. Chest. 2005;127:464-71.
  • 3.De Feo M, Gregorio R, Della Corte A, et al. Deep sternal wound infection: the role of early debridement surgery. Eur J Cardiothorac Surg 2001;19:811-6.
  • 4.Bryan CS, Yarbrough WM. Prevention of Deep Wound Infection after Coronary Artery Bypass Grafting: a review. Tex Heart Inst J. 2013; 40:125-139.
  • 5.Sommerstein R, Kohler P, Wilhelm MJ, et al. Factors associated with methicillin-resistant coagulasenegative staphylococci as causing organisms in deep sternal wound infections after cardiac surgery. New Microbes New Infect. 2015;6:15-21.
  • 6.Lu JC Grayson AD, Jha P, Srinivasan AK, et al. Risk factors for sternal wound infection and mid-term survival following coronary artery bypass surgery. Eur J Cardiothorac Surg 2003;23:943–9.
  • 7.De Feo M, Della Corte A, Vicchio M, et al. Is poststernotomy mediastinitis still devastating after the advent of negative-pressure wound therapy? Tex Heart Inst J. 2011;38:375-80.
  • 8.Argenta LC, Morykwas MJ. Vacuum-assisted closure: a new method for wound control and treatment: clinical experience. Ann Plast Surg 1997;38: 563–76.
  • 9.Horan TC, Andrus M, Dudeck MA. CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Am J Infect Control. 2008;36:309-32.
  • 10.El Oakley RM, Wright JE. Postoperative mediastinitis: classification and management. Ann Thorac Surg 1996;61: 1030-6.
  • 11.Loop FD, Lytle BW, Cosgrove DM, et al. Sternal wound complications after isolated coronary artery bypass grafting: early and late mortality, morbidity, and cost of care. Ann Thorac Surg 1990;49:179–87.
  • 12.Shi YD, Qi FZ, Zhang Y. Treatment of sternal wound infections after open-heart surgery. Asian J Surg. 2014;37:24-9.
  • 13.Durgun M, Durgun SÖ, Özakpınar HR, et al. Approach to of infected sternotomy wounds in the management of mediastinitis. Turk Gogus Kalp Dama 2012;20:820-5.
  • 14.Tschudin-Sutter S, Meinke R, Schuhmacher H, et al. Drainage days–an independent risk factor for serious sternal wound infections after cardiac surgery: A case control study. Am J Infect Control. 2013; 41:1264-7.
  • 15.Hersh RE, Kaza AK, Long SM, et al.A technique for the treatment of sternal infections using the Vacuum Assisted Closure device. Heart Surg Forum 2001;4:211-5.
  • 16.Ağır H, Özkeskin B, Akbaş H, et al. Triple flap sternal wound closure technique in deep mediastinitis in one. T J Thorac Cardivasc Surg 2005;13:171-3.
  • 17.Fleck TM, Fleck M, Moidl R, et al. The vacuumassisted closure system for the treatment of deep sternal wound infections after cardiac surgery. Ann Thorac Surg 2002;74:1596-600.
  • 18.Agarwal JP, Ogilvie M, Wu LC, et al. Vacuumassisted closure for sternal wounds: a first-line therapeutic management approach. Plast Reconstr Surg 2005;116:1035-40.
  • 19.Vos RJ, Yilmaz A, Sonker U, et al. Vacuum-assisted closure of post-sternotomy mediastinitis as compared to open packing. Interact Cardiovasc Thorac Surg. 2012;14(1):17-21.
  • 20.Obdeijn MC, de Lange MY, Lichtendahl DH, et al. Vacuum-assisted closure in the treatment of poststernotomy mediastinitis. Ann Thorac Surg 1999;68:2358-60.
  • 21.Mokhtari A, Sjögren J, Nilsson J, et al.The cost of vacuum-assisted closure therapy in treatment of deep sternal wound infecti on. Scand Cardiovasc J 2008;42:85-9.
  • 22.Song DH, Wu LC, Lohman RF, et al. Vacuum assisted closure for the treatment of sternal wounds: the bridge between débridement and definiti ve closure. Plast Reconstr Surg 2003;111:92-7.
  • 23.Damiani G, Pinnarelli L, Sommella L, et al. Vacuum-assisted closure therapy for patients with infected sternal wounds: a meta-analysis of current evidence. J Plast Reconstr Aesthet Surg 2011;64:1119–23.
  • 24.Steingrimsson S, Gottfredsson M, GudmundsdottirI, et al. Negative-pressure wound therapy for deep sternal wound infections reduces the rate of surgical interventions for early reinfections. Interact CardioVasc Thorac Surg 2012;15:406–10
Kocaeli Tıp Dergisi-Cover
  • ISSN: 2147-0758
  • Başlangıç: 2012
  • Yayıncı: -