Erkingül BİRDAY, Murat ATMACA, Esme EKİZOĞLU, Murat KÜRTÜNCÜ, Mefküre ERAKSOY

Travma ve Multipl Skleroz

Multipl skleroz ve travma arasındaki ilişki yıllardır tartışılan bir konudur. Kafa ve boyun travmaları kan beyin bariyerinde değişikliğe yol açarak bazı multipl skleroz hastalarında yeni ve rekürren belirtileri tetikleyebilmektedir. Bu bildiride ağır kafa ve boyun travma öyküsü olan, bu travma sonrası multipl skleroz belirtileri gösteren, mevcut travmaları ile multipl skleroz arasındaki ilişki irdelenen olgular literatür eşliğinde tartışılacaktır.

Anahtar Kelimeler:

Multipl skleroz, travma, kan-beyin bariyeri

PDF

___

Al-Afasy HH, Al-Obaidan MA, Al-Ansari YA, Al-Yatama SA, Al-Rukaibi MS, Makki NI, Suresh A, Akhtar S. Risk Factors for Multiple Sclerosis in Kuwait: A Population-Based Case-Control Study. Neuroepidemiology. 2013; 40 (1): 30-5.
Kang JH, Lin HC. Increased risk of multiple sclerosis after traumatic brain injury: a nationwide population-based study. J Neurotrauma. 2012; 29 (1); 90-5.
Charles M. Poster. Trauma to the Central Nervous System May Result in Formation or Enlargement of Multiple Sclerosis Plaques. Arch Neurol. 57: 1074-1076.
Compston D, Immunological aspects of MS. In: Matthews WB, ed. McAlpine’s Multiple Sclerosis. 2nd ed, New York, NY: Churchill-Livingstone Inc., 1991: 321-39.
Hickey WF. Migration of hematogenous cells through the blood-brain barrier and the initiation of CNS inflammation. Brain Pathol. 1991; 1(2): 97-105.
Mc Alpine D. The problem of disseminated sclerosis. Brain. 1946; 69: 233-50.
Miller H. Trauma and MS. Lancet. 1964; 1: 848-850.
Levin H, Amparo E, Eisenberg HM, Williams DH, High WM Jr, McArdle CB, Weiner RL. Magnetic resonance imaging and computerized tomography in relation to neuro-behavioral sequelae of mild and moderate head injuries. J Neurosurg. 1987; 66: 706-713.
Ommaya A, Rockoff D, Baldwin M. Experimental cocussion: a first report. J Neurosurg. 1964; 21: 249-265.
Rinder L, Olsson Y. Studies on vascular permeability in experimental brain concussion. Acta Neuropathol. 1968; 11: 185-200.
Goodman J, Bingham W, Hunt W. Ultrastructural blood-brain barrier alteration and edema formation in acute spinal cord trauma. J Neurosurg. 1976; 44: 418-24.
Kapadia S. Ultrastructural alterations in blood vessels of the white matter after experimental cord trauma. J Neurosurg. 1984; 61: 539-44.
Kobrine A; Doyle T, Rizzoli H. The effect of antihistamines pn experimental psotraumatic edema of the spinal cord. Surg Neurol. 1976; 5: 307-09.
Oppenheimer D. The cervical cord in multiple sclerosis. Neuropathol Appl Neurobiol. 1978; 4: 151-162.
Chaudhuri A, Behan PO. Acute cervical hyperextension-hyperflexion injury may precipitate and/or exacerbate symptomatic multiple sclerosis. Eur J Neurol. 2001; 8 (6): 659-64.
Goodin DS, Ebers GC, Johnson KP, Rodriguez M, Sibley WA, Wolinsky JS. The relationship of MS to physical trauma and psychological stress: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Neurology; 52(9): 1737-45.
Goldacre MJ, Abisgold JD, Yeates DG, Seagroatt V. Risk of multiple sclerosis after head injury: record linkage study. J Neurol Neurosurg Psychiatry. 2006; 77(3): 351–3.
Pfleger CC, Koch-Henriksen N, Stenager E, Flachs EM, Johansen C. Head injury is not a risk factor for multiple sclerosis: a prospective cohort study. Mult. Scler. 2009; 15(3): 294-8.