Muhammed SEYİTHANOĞLU, Yılmaz İNANÇ, Songül BAVLİ

Üriner Sistem Semptomları Olan Multipl Sklerozlu Hastalarda Üriner Sinir Büyüme Faktörü Düzeyleri

Amaç: MS hastalarında idrar sinir büyüme faktörünün (NGF) duyarlılığını ve özgüllüğünü detrüsör aşırı aktivitesinin belirteçleri olarak tahmin etmek. Materyal ve Metod: Multipl Skleroz tanısı ile takip edilen üriner sistem semptomları olan 20 gönüllü hasta ve Multipl Skleroz tanısı olan ancak üriner sistem semptomları olmayan 29 gönüllü hasta çalışmaya dahil edildi. Kişilerden kapsamlı bir anamnez ve spot idrar örnekleri alındı. Benzer yaş ve cinsiyet dağılımına sahip 27 sağlıklı gönüllü NGF düzeyleri açısından karşılaştırma yapmak üzere dahil edildi ve spot idrar örnekleri alındı. Bulgular: İdrar NGF düzeyleri ve NGF/idrar Kreatinin oranları üriner semptomları bulunan MS hasta grubunda üriner semptomları bulunmayan hasta grubuna göre istatistiki olarak anlamlı olmayan şekilde daha düşüktü, üriner semptomları olmayan hasta grubunda da control grubuna göre istatistiki olarak anlamlılık içermeyen düşüklük gözlendi (p: 0,114 ve 0,833) Sonuç: Multipl sklerozlu hastalarda idrar nörotrofinleri detrüsör aşırı aktivitesini teşhis etmek için kullanılabilir.

Anahtar Kelimeler:

Multipl skleroz, sinir büyüme faktörü, idrar yolu disfonksiyonu

Urinary Nerve Growth Factor Levels In Multiple Sclerosis Patients With Urinary System Symptoms

Aim: To estimate the sensitivity and specificity of the serum and urinary nerve growth factor (NGF) in MS patients as markers of detrusor overactivity. Materials and Methods: 20 volunteers who were diagnosed with MS and who had urinary tract symptoms and 29 volunteers who were diagnosed with MS however who did not have urinary tract symptoms were included in the study. A comprehensive anamnesis and spot urine samples were obtained from the subjects. Twenty seven healthy volunteers with similar age and gender distribution were included for making a comparison with regard to NGF levels and spot urine samples were obtained. Results: Urinary NGF levels and NGF/urinary creatinine ratios were found lower in the group composed of MS patients who had urinary symptoms compared to the group composed of MS patients who did not have urinary symptoms but the difference was not statistically significant. These parameters were found lower in patient group who did not have urinary symptoms compared to control group however the difference was not statistically significant (p: 0,114 and 0,833) Conclusions: urinary neurotrophins in patients with multiple sclerosis can be used to diagnose detrusor overactivity.

Keywords:

Multiple sclerosis, nerve growth factor, urinary tract dysfunction,

Tam Metin

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Bibtex	@araştırma makalesi { ksutfd793595, journal = {Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi}, issn = {1303-6610}, eissn = {2547-9598}, address = {}, publisher = {Kahramanmaraş Sütçü İmam Üniversitesi}, year = {2021}, volume = {16}, number = {2}, pages = {273 - 278}, doi = {10.17517/ksutfd.793595}, title = {Urinary Nerve Growth Factor Levels In Multiple Sclerosis Patients With Urinary System Symptoms}, key = {cite}, author = {Seyithanoğlu, Muhammed and İnanç, Yılmaz and Bavli, Songül} }
APA	Seyithanoğlu, M. , İnanç, Y. & Bavli, S. (2021). Urinary Nerve Growth Factor Levels In Multiple Sclerosis Patients With Urinary System Symptoms . Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi , 16 (2) , 273-278 . DOI: 10.17517/ksutfd.793595
MLA	Seyithanoğlu, M. , İnanç, Y. , Bavli, S. "Urinary Nerve Growth Factor Levels In Multiple Sclerosis Patients With Urinary System Symptoms" . Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi 16 (2021 ): 273-278 <
Chicago	Seyithanoğlu, M. , İnanç, Y. , Bavli, S. "Urinary Nerve Growth Factor Levels In Multiple Sclerosis Patients With Urinary System Symptoms". Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi 16 (2021 ): 273-278
RIS	TY - JOUR T1 - Üriner Sistem Semptomları Olan Multipl Sklerozlu Hastalarda Üriner Sinir Büyüme Faktörü Düzeyleri AU - MuhammedSeyithanoğlu, Yılmazİnanç, SongülBavli Y1 - 2021 PY - 2021 N1 - doi: 10.17517/ksutfd.793595 DO - 10.17517/ksutfd.793595 T2 - Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi JF - Journal JO - JOR SP - 273 EP - 278 VL - 16 IS - 2 SN - 1303-6610-2547-9598 M3 - doi: 10.17517/ksutfd.793595 UR - Y2 - 2020 ER -
EndNote	%0 Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi Urinary Nerve Growth Factor Levels In Multiple Sclerosis Patients With Urinary System Symptoms %A Muhammed Seyithanoğlu , Yılmaz İnanç , Songül Bavli %T Urinary Nerve Growth Factor Levels In Multiple Sclerosis Patients With Urinary System Symptoms %D 2021 %J Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi %P 1303-6610-2547-9598 %V 16 %N 2 %R doi: 10.17517/ksutfd.793595 %U 10.17517/ksutfd.793595
ISNAD	Seyithanoğlu, Muhammed , İnanç, Yılmaz , Bavli, Songül . "Urinary Nerve Growth Factor Levels In Multiple Sclerosis Patients With Urinary System Symptoms". Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi 16 / 2 (Temmuz 2021): 273-278 .
AMA	Seyithanoğlu M. , İnanç Y. , Bavli S. Urinary Nerve Growth Factor Levels In Multiple Sclerosis Patients With Urinary System Symptoms. KSÜ Tıp Fak Der. 2021; 16(2): 273-278.
Vancouver	Seyithanoğlu M. , İnanç Y. , Bavli S. Urinary Nerve Growth Factor Levels In Multiple Sclerosis Patients With Urinary System Symptoms. Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi. 2021; 16(2): 273-278.
IEEE	M. Seyithanoğlu , Y. İnanç ve S. Bavli , "Urinary Nerve Growth Factor Levels In Multiple Sclerosis Patients With Urinary System Symptoms", , c. 16, sayı. 2, ss. 273-278, Tem. 2021, doi:10.17517/ksutfd.793595