Enflamatuvar Biyobelirteçler Kullanılarak Negatif Apendektomi ve Şiddetli Apendisit İçin Riskli Hastaların Öngörülmesi

Amaç: Bu çalışmanın amacı yetişkinlerde akut apandisit nedeniyle yapılan apendektomilerde negatif laparotomiyi ve akut apandisitin şiddetini ön görmede tam kan sayımının (CBC), enflamatuvar biyo-belirteçlerin, bu parametreler kullanılarak hesaplanan indekslerin ve C-reaktif protein (CRP) seviyelerinin etkinliğinin değerlendirilmesidir. Gereç ve Yöntemler: Bu kesitsel ve gözlemsel çalışmaya Ocak 2015 ile Kasım 2020 tarihleri arasında apendektomi geçirmiş 1389 hasta dâhil edilmiştir. Hastaların yaşı, cinsiyeti ve preoperatif kan tahlillerindeki CRP değerleri, CBC’ye ait enflamatuvar parametreleri ve patolojik tanıları kaydedilmiştir. Gruplar arasında çok değişkenli analizler ve lojistik regresyon analizleri yapılmıştır. Bulgular: Çok değişkenli analiz sonucunda beyaz küre sayısı (WBC), trombosit sayısı (PLT), ortalama trombosit volümü (MPV), mutlak nötrofil ve lenfosit sayıları, nötrofil oranı (%NEU), lenfosit oranı (%LYM), nötrofil/lenfosit oranı (NLR), platelet/lenfosit oranı (PLR) ve CRP/lenfosit oranı (CLR) negatif laparotomiyi anlamlı olarak predikte eden parametreler olarak belirlenmiştir (sırasıyla p

Anahtar Kelimeler:

Akut apandisit, Komplike apandisit, Nötrofil/lenfosit oranı, CRP, Negatif laparotomi

Predicting High Risk Patients for Negative Appendectomy and Severe Appendicitis Using Inflammatory Biomarkers

Objective: The aim of the present study is to evaluate the value of inflammatory parameters and indices of complete blood count (CBC) and C-reactive protein (CRP) in predicting negative laparotomies and severity of acute appendicitis in adults. Material and Methods: A total of 1389 patients who had undergone appendectomy between January 2015 and November 2020 were enrolled in this observational and cross-sectional study. Age, gender, preoperative CRP values, inflammatory parameters of CBC and the pathologic diagnosis were recorded. Multivariate analysis and logistic regression analysis were performed. Results: In multivariate model white blood cell (WBC), platelet count (PLT), mean platelet volume (MPV), absolute neutrophil and lymphocyte counts, neutrophil percentage (NEU%), lymphocyte percentage (LYM%), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio and CRP-to-lymphocyte ratio (CLR) were significant discriminators of negative laparotomy (p

Keywords:

Acute appendicitis, Complicated appendicitis, CRP, Negative laparotomy, Neutrophil-to-lymphocyte ratio,

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