Saime SAĞIROĞLU, Metin KILINÇ, Muhammed Gazi YILDIZ, İrfan KARA, Nagihan BİLAL, İsrafil ORHAN

İdiyopatik Subjektif Tinnituslu Hastaların Trombosit Fonksiyonlarının Değerlendirilmesi

Amaç: Bu çalışmada, idiyopatik subjektif tinnituslu hastalarda, trombosit fonksiyonları değerlendirildi. Bu amaçla trombositlerin agonistlere cevap olarak yaptıkları agregasyon eğrisini inceleyen bir test olarak kullanılan adenozin difosfat (ADP) ve kollajen ile tetiklenen trombosit agregasyon düzeyleri araştırıldı. Gereç ve Yöntemler: Çalışmaya, kliniğe en az 1 yıldır devam eden idiyopatik subjektif tinnitus şikâyeti olan hastalar alındı. İdioyopatik subjektif tinnitusu olan otuz üç hasta ve tinnitus şikayeti olmayan 33 kontrol grubu olmak üzere toplamda 66 kişi dâhil edildi. Tinnitus Handikap İndeksi (THI), tinnitus şiddetini ölçmek için tüm hastalar tarafından dolduruldu. Hastalardan alınan kanda, trombosit sayısı, protrombin zamanı (PT), parsiyel tromboplastin zamanı (aPTT), çalışıldı. Kanda adenozin difosfat kollajenaz (ADP) ve epinefrin kollajenaz ölçüldü. ADP ve kollajen, bir Chrono-log trombosit agregometre cihazında bir Chrono-log kiti kullanılarak ölçüldü. Bulgular: THI’ya göre evre 1’de 4 hasta (%12.1), evre 2’de 8 hasta (%24.2), evre 3’de 10 hasta (%30.3), evre 4’de 7 hasta (%21.2), ve evre 5’de 4 hasta (%12.1) mevcuttu. Tinnituslu hastalarda ADP ile tetiklenen agregasyonda ortalama değer 83.85±16.80 (%), kontrol grubunda ise 91.88±20.67 (%) bulundu ve istatistiksel olarak anlamlı bir fark saptanmadı (p>0.05). Kollajen ile tetiklenen trombosit agregasyonunda tinnituslu hastalarda ortalama değer %119.24±24.76, kontrol grubunda %130.79±38.73 idi ve istatistiksel olarak anlamlı bir fark saptanmadı (p>0.05). Sonuç: Sonuç olarak, trombosit fonksiyonları idiopatik subjektif tinnituslu hastalarda normal olarak değerlendirildi. Ancak, ölçülen değerlerin kontrol grubuna göre daha düşük olmasından dolayı trombosit agregasyonuna eğilimli olduğu tespit edildi.

Anahtar Kelimeler:

Adenozin difosfat, Kollajen. Tinnitus, Trombosit agregasyonu

An Evaluation of Thrombocyte Functions in Patients with Idiopathic Subjective Tinnitus

Objective: The aim of this study was to investigate the thrombocyte agggregation levels which are triggered by adenosine diphosphate (ADP) and collagen in patients with idiopathic subjective tinnitus. Material and Methods: The study included 33 patients who presented at the clinic with complaints of idiopathic subjective tinnitus that had been ongoing for at least 1 year and a control group of 33 subjects with no complaints of tinnitus. The Tinnitus Handicap Index (THI) was completed by all the patients to measure tinnitus severity. Thrombocyte count, prothrombin time (PT), and partial thromboplastin time (aPTT) were examined in blood samples taken from the patients. Adenosine diphosphate (ADP) collagenase and epinephrine collagenase were measured in the blood. Results: According to the THI, 4 (12.1%) patients were grade 1, 8 (24.2%) patients were grade 2, 10 (30.3%) patients were grade 3, 7 (21.2%) were grade 4 and 4 (12.1%) patients were grade 5. Mean aggregation triggered by ADP was determined as 83.85±16.80%in the tinnitus patients and 91.88±20.67% in the control group, with no statistically significant difference determined (p>0.05). The mean thrombocyte aggregation triggered by collagen was determined as 119.24±24.76% in the tinnitus patients and 130.79±38.73% in the control group, with no statistically significant difference determined (p>0.05). Conclusion: The thrombocyte functions were evaluated as normal in patients with idiopathic subjective tinnitus. However, as the measured values were lower than those of the control group, there was determined to be a tendency for thrombocyte aggregation.

Keywords:

Adenosine diphosphate Collagen, Tinnitus, Thrombocyte aggregation,

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