Polikistik Over Sendromu ve Uyku Bozuklukları: Uyku Bileşenleri ile Metabolik ve Androjenik Bozukluklar Arasındaki İlişki

Amaç: Polikistik over sendromlu (PKOS) hastalarda uyku kalitesinin araştırılması ve metabolik parametrelerin uyku bozuklukları üzerine etkilerini incelenmesi amaçlanmıştır. Gereç ve Yöntemler: Çalışmaya PKOS tanısı alan 50 hasta ve 51 normal sağlıklı gönüllü dahil edildi. Uyku kalitesini değerlendirmek için Pittsburgh Uyku Kalitesi İndeksi (PSQİ) kullanıldı. İndeks, 18 madde ve yedi bileşenden oluşmaktadır ve endekse göre alınan beş veya daha fazla toplam puan, kötü uyku kalitesini göstermektedir. Uyku kalitesi skorları belirlendikten sonra serum insülin, trigliserit, kolesterol, açlık glikoz ve androjen seviyeleri geriye dönük olarak kaydedildi ve tüm parametreler gruplar arasında karşılaştırıldı. Bulgular: PKOS’lu hastalarda uyku kalitesi, sağlıklı kontrol grubuna göre daha düşüktü fakat istatistiksel olarak anlamlı değildi (p>0.05). Serum Dihidroepiandrosteron sülfat (DHESO4) ve total testosteron düzeyi ile uyku süresi ve toplam PSQİ skorları arasında anlamlı negatif korelasyon vardı. Ek olarak serum total testosteron düzeyi ile de uyku gecikmesi, uyku bozuklukları ve öznel uyku kalitesi arasında anlamlı negatif korelasyon saptandı. Ayrıca uyku kalitesi düşük olan hastaların serum DHESO4 ve testosteron düzeyleri normal uyku kalitesine sahip olanlara göre anlamlı olarak daha düşüktü (p

Anahtar Kelimeler:

Dislipidemi, Pittsburgh Uyku Kalitesi İndeksi, Polikistik over sendromu, Uyku kalitesi

Polycystic Ovary Syndrome and Sleep Disorders: Association Between Metabolic and Androgenic Alterations with Sleep Components

Objective: To investigate the sleep quality in patients with polycystic ovary syndrome (PCOS) and to examine the effects of metabolic parameters on sleep disturbances. Material and Methods: The study included 50 patients diagnosed as PCOS and 51 normal healthy volunteers. The Pittsburgh Sleep Quality Index (PSQI) was used to evaluate the sleep quality. Index consists of 18 items and seven components and according to the index, the total scores of five or more indicate a poor sleep quality. After the sleep quality scores were determined, serum insulin, triglyceride, cholesterol, fasting glucose and androgen levels were recorded retrospectively and all parameters compared between groups. Results: The sleep quality was lower in the patients with polycystic ovary syndrome than in the healthy control group but this was not statistically significant (p>0.05). Serum dehydroepiandrosterone sulfate (DHESO4) and total testosterone level had a significant negative correlation with sleep duration and total PSQI scores. In addition, serum total testosterone level also had a significant negative correlation with sleep latency, sleep disturbance and subjective sleep quality. Besides, the patients with the poor sleep quality had significantly lower serum dehydroepiandrosterone sulfate and testosterone levels than those with a normal sleep quality (p

Keywords:

Dyslipidemia, The Pittsburgh Sleep Quality Index, Polycystic ovary syndrome, Sleep quality,

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