Covid-19 Hastalarının Kan Gazı Ölçümleri ve Hematolojik Manifestasyonlarının Mortalite ile İlişkisi: Retrospektif Analiz

Amaç: Amacımız, COVİD-19’lu hastaların yoğun bakım ünitesine yatış ve sonrası dönemde kan gazı ve tam kan sayımı parametrelerinin mortalite ile ilişkilerini araştırmaktır. Gereç ve Yöntemler: Hastalar grup yaşamayan ve grup yaşayan olarak iki gruba ayrıldı. Hematolojik parametreler 1, 3, 5. gün kaydedildi. Bulgular: Yüz kırk iki hasta retrospektif olarak analiz edildi. Bunların 46’sı (%32) kadındı. 71 hasta (%50) yaşamayan gruptaydı. Yaşamayan grupta ortalama yaş 61, yaşayan grupta ortalama yaş 60’tı. Noninvaziv ventilasyon günü ve invaziv ventilasyon günü yaşamayan grupta daha yüksekti. Yaşamayan grupta yoğun bakıma yatışta, 3.günde ve 5.günde PO2/FiO2 (p

Relationship of Blood Gas Measurements and Hematological Manifestations of COVID-19 Patients with Mortality: Retrospective Analysis

Objective: The aim was to investigate the relationship between blood gas and complete blood count parameters and mortality in patients with COVID-19 during and after in the intensive care unit (ICU). Material and Methods: Patients were divided as group nonsurvivor and group survivor. Hematological parameters were registered on the day 1, 3, 5. Results: A total of 142 patients were analyzed retrospectively in the study. Out of them, 46 were women (32%). Seventy-one patients were in group nonsurvivor (50%). The median age of group nonsurvivor patients was 61 years, and the median age of group survivor patients was 60 years. Noninvasive ventilation day and mechanical ventilation day were higher in group nonsurvivor. In group nonsurviver, at the admission to the ICU, in the third day and in the fifth day of ICU, PO2/FiO2 (p

___

  • World Health Organization. Coronavirus Disease (COVID-19) Outbreak. https://www.who.int. Accessed January 31, 2022.
  • Sun X, Wanga T, Cai D, Hu Z, Chen J, Liao H et al. Cytokine storm intervention in the early stages of COVID-19 pneumonia. Cytokine and Growth Factor Rev. 2020;53:38–42.
  • Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z et al. Clinical course and risk factors for mortality of adult inpatients with COVID- 19 in Wuhan, China: a retrospective cohort study. Lancet. 2020;395:1054–1062.
  • Chen G, Wu D, Guo W, Cao Y, Huang D, Wang H et al. Clinical and immunological features of severe and moderate coronavirus disease 2019. J Clin Invest. 2020;130:2620–2629.
  • Lippia G, Plebanib M, Henry BM. Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A meta-analysis. Clin Chim Acta. 2020;506:145–148.
  • Russell CD, Parajuli A, Gale HJ, Bulteel NS, Schuetz P, de Jager CPC et al. The utility of peripheral blood leucocyte ratios as biomarkers in infectious diseases: a systematic review and meta-analysis. J Infect. 2019;78 (5):339–348.
  • Peng J, Qi D, Yuan G, Deng X, Mei Y, Feng L et al. Diagnostic value of peripheral hematologic markers for coronavirus disease 2019 (COVID-19): A multicenter, cross-sectional study. J. Clin. Lab. Anal. 2020;34(10): e23475.
  • Fois AG, Paliogiannis P, Scano V, Cau S, Babudieri S, Perra R et al. The Systemic Inflammation Index on Admission Predicts In-Hospital Mortality in COVID-19 Patients. Molecules. 2020;25(23):5725.
  • Kucukcan NE, Kucukcan A. The relationship between hemogram parameters with clinical progress in COVID-19 patients. Dicle Med J. 2020;47(4):763-769
  • Yang X, Yu Y, Xu J, Shu H, Xia J, Liu H et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: A single-centered, retrospective, observational study. Lancet Respir Med. 2020;8(5):475–481. Deng Y, Liu W, Liu K, Fang YY, Shang J, Zhou L et al. Clinical characteristics of fatal and recovered cases of coronavirus disease 2019 in Wuhan, China: a retrospective study. Chin Med J (Engl). 2020;133(11):1261–1267.
  • Qin C, Zhou L, Hu Z, Zhang S, Yang S, Tao Y et al. Dysregulation of immune response in patients with COVID-19 in Wuhan, China, Clin Infect Dis. 2020;71(15):762–768. 13. Guan WJ, Ni ZY, Hu Y, W. Liang, C. Ou, J. He et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 2020;382:1708–1720.
  • Sun D, Zhang D, Tian R, Li Y, Wang Y, Cao J et al. The underlying changes and predicting role of peripheral blood inflammatory cells in severe COVID-19 patients: A sentinel? Clinica Chimica Acta 2020;508:122–9. 15. Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China. JAMA. 2020;323(11):1061–1069.
  • Wu C, Chen X, Cai Y, Xia J, Zhou X, Xue S et al. Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China. JAMA Intern Med. 2020;180(7):934–943. 17. Zhang H, Cao X, Kong M, Mao X, Huang L, He P et al. Clinical and hematological characteristics of 88 patients with COVID-19. Int J Lab Hematol. 2020;42 (6):780–787.
  • Li X, Liu C, Mao Z, Xiao M, Wang L, Qi S et al. Predictive values of neutrophil-to-lymphocyte ratio on disease severity and mortality in COVID-19 patients: a systematic review and meta- analysis. Crit Care. 2020;24(1):647.
  • Jenne CN, Kubes P. Platelets in inflammation and infection. Platelets. 2015;26 (4):286-292.
  • Qu R, Ling Y, Zhang YH, Wei L, Chen X, Li XM, et al. Platelet- to-lymphocyte ratio is associated with prognosis in patients with coronavirus disease-19. J Med Virol. 2020;92(9):1533-1541.
  • Yang AP, Liu JP, Tao WQ, Li HM. The diagnostic and predictive role of NLR, d-NLR and PLR in COVID-19 patients. Int Immunopharmacol. 2020;84:106504.
  • Lagunas-Alvarado M, Mijangos-Huesca FJ, Teran-Gonz ´ alez JO, Alvarado L, Zavala M, Franco R et al. Systemic immune inflammatory index in sepsis. Med. Int. M´ex. 2017;33(3),303–309.
  • Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395 (10223):497–506.
Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi-Cover
  • ISSN: 1303-6610
  • Yayın Aralığı: Yılda 3 Sayı
  • Başlangıç: 2004
  • Yayıncı: Kahramanmaraş Sütçü İmam Üniversitesi
Sayıdaki Diğer Makaleler

Asistan Hekimlerde Tükenmişlik Sendromu

Elif BEYOĞLU, Ayşegül ERDOĞAN, Ramazan Azim OKYAY

Neonatal Sepsis Şüphesi Olan Yenidoğanlarda Akut Faz Reaktanı Olarak C Reaktif Protein, Prokalsitonin, İnterlökin-18 Düzeylerinin Değerlendirilmesi

Büşra SEĞMEN, Sadık YURTTUTAN, Nurten SERİNGEÇ AKKEÇECİ, Fatma İNANÇ TOLUN, Aydın BOZKAYA

RT-PCR Pozitif COVID-19 Pnömonili Hastalarda Radyolojik Bulguların ve Akciğer Tutulum Oranının Değerlendirilmesi

Bedriye KOYUNCU SÖKMEN, Soheil SABET

Karaciğer Sirozu Tanısı ile Takip Edilen Konstriktif Perikardit Olgusu

Murat KERKÜTLÜOĞLU, Enes ÇELİK, Bayram ÖZTÜRK, Hakan GÜNEŞ

İdiyopatik Subjektif Tinnituslu Hastaların Trombosit Fonksiyonlarının Değerlendirilmesi

Saime SAĞIROĞLU, Metin KILINÇ, Muhammed Gazi YILDIZ, İrfan KARA, Nagihan BİLAL, İsrafil ORHAN

İnce Barsak Atrezi ve Stenozu Olgularında Sağ Kalımı Etkileyen Faktörler

Selcan TÜRKER ÇOLAK, Murat ALKAN, Recep TUNCER

Gebelikte Ödem ve Proteinürinin Çok Nadir Görülen Bir Nedeni: Mirror Sendromu

Abdullah TOK, Fatma Betül GÜZEL, İlyas OZTURK, Ertuğrul ERKEN, Orçun ALTUNÖREN, Özkan GÜNGÖR

Covid-19 Hastalarının Kan Gazı Ölçümleri ve Hematolojik Manifestasyonlarının Mortalite ile İlişkisi: Retrospektif Analiz

Refika KILIÇKAYA, Yavuz ORAK, Filiz ORAK, Adem DOĞANER

Kronik Aort Yetmezliği Olan Hastalarda Hipertansiyon Sıklığı

Oguzhan YÜCEL, Hakan GÜNEŞ, Mehmet Birhan YILMAZ

İnmeli Hastalarda Malnütrisyon ve Disfajinin Önemi

Nurbanu GÜÇMEN, Burhan GÜÇMEN, Tuba Tülay KOCA