İBRAHİM AKYAZI, EVREN ERASLAN, Deniz BALA AKTARAN, L. Zeynep ÇIRAKLI, ÜLKER ÇÖTELİOĞLU

The effects of D-Ala2, D-Leu5-enkephalin (DADLE)'s continuous perfusion on erythrogram and biochemical profile in rats

Bu deneysel çalışmada DADLEnin kronik sürekli uygulamasının bazı eritrositer parametreler (eritrogram) ve biyokimyasal profil (ALP, ALT, AST, LDH, glikoz, üre, kreatinin, albümin, total protein) üzerine olan etkilerinin araştırılması amaçlanmıştır. Çalışmada 48 adet yetişkin erkek Wistar sıçan kullanılmıştır. DADLE deri altına implante edilen ozmotik mini pompalar ile uygulanmıştır. Yirmisekiz günlük uygulama sonrası deney grubu hayvanlarının plazma glikoz düzeyleri artarken üre düzeyleri düşmüş ve bu değişikliklerin kontrol grubu ile karşılaştırıldığında istatistiksel önemde olduğu görülmüştür. İncelenen diğer parametreler açısından gruplar arasındaki farklar istatistiksel olarak önemli bulunmamıştır. Bu nedenle DADLEnin ozmotik mini pompalar ile kronik ve sürekli uygulanmasının sıçanlarda eritrogram ve biyokimyasal profil açısından herhangi bir zararlı etki oluşturmadığı sonucuna varılmıştır.

D-Ala2, D-Leu5-enkephalin (DADLE)in sıçanlarda sürekli perfüzyonunun eritrogram ve biyokimyasal profile etkisi

In this experimental study it was aimed to investigate the effects of chronic continuous DADLE administration on erythrogram and the biochemical profile (ALP, ALT, AST, LDH, glucose, urea, creatinine, albumin, total protein). The study was carried on 48 adult male Wistar rats. DADLE was administered via osmotic mini-pumps, implanted subcutaneously. After the 28-day treatment, plasma glucose levels increased and urea levels decreased significantly in experimental group animals compared to the control group. Differences between the groups were not found to be statistically significant with respect to the other investigated parameters. So we conclude that chronic continuous administration of DADLE via osmotic mini-pumps did not exert any detrimental effect on erythrogram and the biochemical profile in rats.

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