Elif DOĞAN, Latif EMRAH YANMAZ, Ugur ERSOZ, MÜMİN GÖKHAN ŞENOCAK, Zafer OKUMUŞ

The Effect of Different Doses of Intramuscular Xylazine HCl Administration on Intraocular Pressure in Rabbits

Bu çalışmada tavşanlarda 5 mg/kg (XYL-5) ve 10 mg/kg (XYL-10) dozlarda uygulanan Ksilazin HCl'ün intraoküler basınç üzerine etkilerinin belirlenmesi amaçlandı. İntraoküler basınç ölçümleri Ksilazin HCl uygulamasını takiben bazal (T-1), 5 (T5), 10 (T10), 15 (T15), 20 (T20), 30 (T30), 45 (T45) ve 60 (T60) dakikalarda yapıldı. Grup XYL-5'te T15 (8.37±1.45 mm Hg) ve grup XYL-10'da T5'te (8.00±1.13 mm Hg) önemli derecede IOP ölçümlerinin azaldığı belirlendi. Sonuç olarak, doza bakılmaksızın Ksilazin HCl, uygulamadan en geç 15 dakika sonra Beyaz Yeni Zelanda tavşanlarında intraoküler basıncı düşürdü.

Farklı Dozlarda Uygulanan Ksilazin HCl'ün Tavşanlarda İntraoküler Basınç Üzerine Etkisi

This study was aimed to determine the effects of intramuscular Xylazine HCl administration on intraocular pressure (IOP) in rabbits at 5 mg/kg (XYL-5) and 10 mg/kg (XYL-10) doses. IOP measurements were recorded at baseline (T-1), and at 5 (T5), 10 (T10), 15 (T15), 20 (T20), 30 (T30), 45 (T45) and 60 (T60) minutes following Xylazine HCl administration. IOP values were significantly decreased at T15 in group XYL5 (8.37±1.45 mm Hg) and at T5 in group XYL-10 (8.00±1.13 mm Hg). In conclusion, intramuscular Xylazine HCl significantly reduced IOP in rabbits at the latest after 15 minutes of administration, regardless of the doses used in this study.

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