Polymorphism in GHRH Gene and Its Association with Growth Traits in Tibetan Sheep

The objectives of this study were to identify single nucleotide polymorphisms (SNPs) in the growth hormone-releasing hormone (GHRH) gene and to evaluate their associations with growth traits in two main Tibetan sheep breeds. Through sequencing technology, four SNPs were identified in the 5’UTR region of GHRH gene. Both g.794A>C and g.1497C>A exhibited significant inflence on the growth-related traits in Tibetan sheep (P

Tibet Koyunlarında Büyüme Hormonunu Salgılatıcı Hormon (GHRH) Genindeki Polimorfizmlerin Büyüme Özellikleri İle İlişkisi

Bu çalışmanın amacı, büyüme hormonu salgılatıcı hormon (GHRH) genindeki tek nükleotid polimorfizmlerini (SNPs) tanımlamak ve bunların iki Tibet koyun ırkının büyüme özellikleri ile olan ilişkilerini değerlendirmektir. Sıralama teknolojisi ile, GHRH geninin 5’UTR bölgesinde dört SNP tanımlandı. Hem g.794A> C hem de g.1497C> A, Tibet koyunlarında büyümeyle ilgili özellikler üzerinde önemli bir etki gösterdi (P

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1. Xin GS, Long RJ, Guo XS, Irvine J, Ding LM, Ding LM, Sahng ZH: Blood mineral status of grazing Tibetan sheep in the Northeast of the Qinghai-Tibetan Plateau. Livest Sci, 136, 102-107, 2011. DOI: 10.1016/j. livsci.2010.08.007

2. Zhou JW, Mi JD, Titgemeyer EC, Guo XS, Ding LM, Wang HC, Qiu Q, Li ZP, Long RJ: A comparison of nitrogen utilization and urea metabolism between Tibetan and fine-wool sheep. J Anim Sci, 93, 3006-3017, 2015. DOI: 10.2527/jas.2014-8865

3. Raisingani M, Preneet B, Kohn B, Yakar S: Skeletal growth and bone mineral acquisition in type 1 diabetic children; abnormalities of the GH/IGF-1 axis. Growth Horm IGF Res, 34, 13-21, 2017. DOI: 10.1016/j. ghir.2017.04.003

4. Chen D, Liu J, Chen W, Shi S, Zhang W, Zhang L: Expression and ontogeny of growth hormone (Gh) in the protogynous hermaphroditic ricefield eel (Monopterus albus). Fish Physiol Biochem, 41, 1515-1525, 2105. DOI: 10.1007/s10695-015-0104-3

5. Gahete MD, Duran-Prado M, Luque RM, Martinez-Fuentes AJ, Quintero A, Gutierrez-Pascual E, Cordoba-Chacon J, Malagon MM, Gracia-Navarro F, Castano JP: Understanding the multifactorial control of growth hormone release by somatotropes: Lessons from comparative endocrinology. Ann N Y Acad Sci, 1163, 137-153, 2009. DOI: 10.1111/j.1749- 6632.2008.03660.x

6. Isgaard J, Arcopinto M, Karason K, Cittadini A: GH and the cardiovascular system: An update on a topic at heart. Endocrine, 48, 25- 35, 2015. DOI: 10.1007/s12020-014-0327-6

7. Sun YG, Han YC: Genetic polymorphisms of myogenin gene and their associations with growth traits in the Chinese Tibetan Sheep. Kafkas Univ Vet Fak Derg, 23, 253-258, 2017. DOI: 10.9775/kvfd.2016.16371

8. Cordell HJ, Barratt BJ, Clayton DG: Case/pseudocontrol analysis in genetic association studies: A unified framework for detection of genotype and haplotype associations, gene-gene and gene-environment interactions, and parent-of-origin effcts. Genet Epidemiol, 26, 167-185, 2004. DOI: 10.1002/gepi.10307

9. Botstein D, White RL, Skolnick M, Davis RW: Construction of a genetic linkage map in man using restriction fragment length polymorphisms. Am J Hum Genet, 32, 314-331, 1980.

10. Piorkowska K, Ropka-Molik K, Oczkowicz M, Rozycki M, Zukowski K: Association study of PIT1 and GHRH SNPs with economically important traits in pigs of three breeds reared in Poland. Anim Sci Pap Rep, 4, 303- 314, 2013.

11. Dybus A, Kmiec M, Sobek Z, Pietrzyk W, Wisniewski B: Associations between polymorphisms of growth hormone releasing hormone (GHRH) and pituitary transcription factor 1 (PIT1) genes and production traits of limousine cattle. Arch Anim Breed, 46, 527-534, 2003. DOI: 10.5194/aab- 46-527-2003

12. Cheong HS, Yoon DH, Kim LH, Park BL, Choi YH, Chung ER, Cho YM, Park EW, Cheong IC, Oh SJ, Yi SG, Park T, Shin HD: Growth hormonereleasing hormone (GHRH) polymorphisms associated with carcass traits of meat in Korean cattle. BMC Genet, 7:35, 2006. DOI: 10.1186/1471- 2156-7-35

13. Zhang B, Zhao G, Lan X, Lei C, Zhang C, Chen H: Polymorphism in GHRH gene and its association with growth traits in Chinese native cattle. Res Vet Sci, 92, 243-246, 2012. DOI: 10.1016/j.rvsc.2011.01.023

14. Wei DW, Gui LS, Raza SHA, Zhang S, Khan R, Wang L, Guo HF, Zan LS: NRF1 and ZSCAN10 bind to the promoter region of the SIX1 gene and their effcts body measurements in Qinchuan cattle. Sci Rep, 7:7867, 2107. DOI: 10.1038/s41598-017-08384-1

15. Han YC, Sun YG, Li Q: Growth hormone polymorphisms and growth traits in Chinese Tibetan sheep Ovis aries. Genet Mol Res, 15 (3): gmr.15038397, 2016. DOI: 10.4238/gmr.15038397
Kafkas Üniversitesi Veteriner Fakültesi Dergisi-Cover
  • ISSN: 1300-6045
  • Yayın Aralığı: Yılda 6 Sayı
  • Başlangıç: 1995
  • Yayıncı: Kafkas Üniv. Veteriner Fak.
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