Parvoviral hemorajik gastroenteritisli köpeklerin sağıltımında total parenteral beslemenin etkisi

Çalışmada, yaşları 2-6 ay, vücut ağırlıkları 5-16 kg, farklı ırk ve cinsiyette, 20’si parvoviral gastroenteritis (PVGE)’li, 10’u sağlıklı kontrol olmak üzere toplam 30 köpek kullanıldı. Parvokit kullanılarak PVGE oldukları saptanan 20 köpek, biri klasik sağaltım grubu (Grup II), diğeri modifiye sağaltm grubu (Grup III) olmak üzere rastgele onarlı iki gruba ayrıldı. Al]nan kan örneklerinde hematolojik parametreler, kan gazı değerleri ve biyokimyasal parametreler incelenerek total parenteral besleme (TPB)’nin PVGE’in sağaltımındaki etkinliği araştırıldı. Sağaltım öncesi her iki gruptaki hastaların büyük bir bölümünde kontrol grubu (Grup I)’na göre hipoproteinemi ve hipoglisemi görülmesi PVGE’e bağlı bir protein kalori malnutrisyonu (PKM)’nun geliştiğine yorumlandı. Aynı zamanda lökopeninin görülmesi virusun lenfoid dokuları etkilemesine ve PKM’na bağlı lenfoid yetersizlik ve immun fonksiyonların baskılanmasına bağlandı. Klinik ve laboratuvar bulguları dikkate alınarak, her iki gruptaki hastalara asidozis ve dehidrasyonun sağaltımı için %5 dekstroz’lu Laktatlı Ringer, ayrıca baz durumu (BD) -10’dan fazla olan hastalara %1.3’lük sodyumbikarbonat (NaHO3-) solüsyonu uygulandı. Bunlara ek olarak modifiye sağaltım grubuna TPB solüsyonu verildi. Sekonder enfeksiyonlara karş] ceftazidim 25 mg/kg/gün dozunda intravenöz uygulandı. Çalışma sonuna kadar klasik sağaltım grubunda 5 hasta (%50), modifiye sağaltım grubunda ise 1 hasta (%10) öldü. Sonuç olarak, TPB’ye alınan yanıt ve ölüm oranları dikkate alındığında PVGE’in sağaltımında modifiye sağaltımın klasik sağaltıma göre önemli düzeyde etkili olduğu görüldü.

Anahtar Kelimeler:

gastroenteritis, Parvovirus, kan gazları, köpek parvovirüsü, klinik görünüm, köpek, ölüm oranı, parenteral besleme, biyokimyasal parametreler

Effects of total parenteral nutrition in the treatment of dogs with parvoviral hemorrhagic gastroenteritis

In this study, a total of 30 dogs of different breeds and gender, with 2 to 6 months of age and 5-16 kg in body weights were used. The parvokit were used to confirm the PVGE in dogs with hemorrhagic gastroenteritis. Twenty dogs with Parvoviral gastroenteritis (PVGE) were randomly divided into two groups: a traditional treatment group (Group II) and Modified Treatment group (Group III). In Group III, dogs were given Total Parenteral Nutrition (TPN) in addition to the traditional treatment procedure. Ten healthy dogs served as control. The affects of TPN was evaluated based on haematological parameters, blood gases values and blood biochemical profiles in blood samples. Prior to treatment, presence of hypoproteinemia and hypoglycemia in most the dogs with PVGE was interpreted as having protein calorie malnutrition (PCM) related to PVGE. Presence of leukocytopenia in diseased dogs indicated presence of lymphoid insufficiency and immune suppression consequence to the virus effects on lymphoid tissues. Based on clinical findings and the results of laboratory examinations, Lactated Ringer in 5% dextrose solution was intravenously given to all sick dogs to reduce the effects of acidosis and dehydration. In addition, 1.3% NaHCO3- was administered intravenously to diseased dogs with a base excess status greater than -10. Dogs in modified treatment group also received TPN. Against secondary infections, ceftadizim at 25 mg/kg/daily was given intravenously to the dogs with PVGE. Up to the end of the study, 5 dogs (50%) in the traditional treatment group and one dog in modified treatment group died. As a result, total parenteral nutrition in the treatment of PVGE was found more successful than the traditional treatment as evidenced by the lower mortality rate.

Keywords:

gastroenteritis, Parvovirus, blood gases, canine parvovirus, clinical aspects, dogs, mortality, parenteral feeding, biochemical parameters,

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