Hadi IMANI RASTABI, Ahmad KHAJEH, Hadi NADDAF, Bahman MOSALLANEJAD

Orşiektomi Yapılan Sedasyonlu Köpeklerde Epidural Deksmedetomidinin Fizibilite, Reverzibilite ve Kardiyorespiratuvar Etkilerinin Değerlendirilmesi

Bu çalışmanın amacı; orşiektomi yapılan sedasyonlu köpeklerde epidural deksmedetomidinin (DEX) geri dönüşlü sedasyon ve kardiyorespiratuvar değişiklikleri ile yeterli anti-nosisepsiyon üretip üretmediğini değerlendirmekti. Çalışmada ortalama ağıtlıkları 21.7±5.2 kg olan on iki erkek köpek kullanıldı. Köpeklere intramüsküler yolla asepromazin (0.025 mg/kg) ve morfin (0.25 mg/kg) ardından intravenöz yolla (IV) ikinci bir doz morfin (0.125 mg/kg) uygulandı. Tüm köpeklere (n=12) epidural yolla DEX (3 µg/kg) uygulandı. Prescrotal bölgenin tam duyusal blokajı sağlandıktan sonra orşiektomi operasyonu yapıldı. Ameliyat sırasında herhangi bir rahatsızlık tespit edilirse, ağrılı bölgeye 2-3 mL %1’lik lidokain (en fazla iki kez) uygulandı. Epidural uygulamadan altmış dakika sonra, köpekler IV atipamezol (ATP; n=6) veya salin (SAL; n=6) tedavisi alacak şekilde rastgele gruplandırıldı. Köpeklerin hiçbirinde genel anestezi uygulanması gerekmedi; ancak, on iki köpekten dokuzuna lidokain uygulandı. ATP'de duyusal blokajın süresi, SAL'dan daha kısaydı. Kalp atış hızı, solunum hızı ve rektal sıcaklık, DEX uygulamasından sonraki ölçümler ile karşılaştırıldığında önemli ölçüde düşüş gösterdi. Atipamezol uygulaması, sedasyon, duyusal blokaj ve kardiyorespiratuvar değişiklikleri tersine çevirdi. Sonuç olarak, epidural DEX, sedasyon uygulanan köpeklerde orşiektomi sırasında yeterli anti-nosisepsiyon etki üretmediği belirlendi. Epidural DEX'in neden olduğu sedasyon, duyusal blokaj ve kardiyorespiratuvar değişiklikler IV atipamezol uygulamasıyla tersine çevrilebilir.

Evaluation of the Feasibility, Reversibility and Cardiorespiratory Effcts of Epidural Dexmedetomidine in Sedated Dogs Undergoing Orchiectomy

The objective of the present study was to evaluate whether epidural dexmedetomidine (DEX) produces sufficient anti-nociception withreversible sedation and cardiorespiratory changes in sedated dogs undergoing orchiectomy. Twelve male dogs weighing 21.7±5.2 kg wereused. Dogs received acepromazine (0.025 mg/kg) and morphine (0.25 mg/kg) intramuscularly and a second dose of morphine (0.125 mg/kg)intravenously (IV). DEX (3 µg/kg) was administered epidurally to all dogs (n=12). After confirming complete sensory blockade of the prescrotalregion, orchiectomy was performed. If any discomfort was detected during surgery, 2-3 mL lidocaine 1% (maximum two times) was appliedinto the painful area. Sixty minutes after epidural application, dogs were randomly assigned to receive either treatment of atipamezole(ATP; n=6) or saline (SAL; n=6) IV. None of the dogs required general anesthesia; however, nine out of twelve dogs received lidocaine. Theduration of sensory blockade was significantly shorter in ATP than that of SAL. Heart rate, respiratory rate, and rectal temperature showedsignificantly lower values compared with base after administration of DEX. Administration of atipamezole reversed sedation, sensory blockadeand cardiorespiratory changes. In conclusion, epidural DEX did not produce adequate anti-nociception during orchiectomy in sedated dogs.Sedation, sensory blockade and cardiorespiratory changes induced by epidural DEX can be reversed by IV administration of atipamezole.

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