Küçük Hayvan Cerrahisinde Gözardı Edilen Bir Başlık: Dalak Hastalıkları

Vücutta hayati öneme sahip bir işlevi olan dalak, karnın sol kısmında yer alır. Dalağın birincil görevleri, kan hücrelerinin rezervuarı ve bağışıklıksisteminin savunma hücrelerinin üretilmesi gibi hematopoez ve bağışıklık olaylarıdır. Çoğu zaman -klinik belirtilerin patognomik olmaması nedeniyle- dalak hastalıkları, operasyon esnasında rastlantısal olarak tespit edilmektedir. Splenoz dalak dokusunun diğer vücut kompartmanlarındaki heterotopik bir ototransplantasyonudur ve görüntüleme esnasında patolojik bir durum olarak yorumlanabilir. Yaşlanma sürecine bağlı olarak dalakta demir birikimi yani sideroz gibi yabancı madde birikimleri izlenebilir. Dalağın patolojileri çoğunlukla organın genişlemesi (splenomegali) ile karakterizedir. Hemanjiyosarkom, dalakta en sık karşılaşılan neoplazidir ve genellikle kalbin sağ atriyumuna metastaz yapar. Ultrasonografi, dalak bozukluklarının tanısında en sık kullanılan tanı aracıdır. Ayrıca manyetik rezonans görüntüleme (MRG) ve bilgisayarlı tomografi (BT) teknikleri de kullanılabilir. Preoperatif dönemde tam kan, plazma veya her ikisi birden hazır edilmelidir. Dalak patolojilerinin cerrahi müdahaleleri arasında splenorafi, parsiyel splenektomi ve total splenektomi sayılabilir. Dalak yaralanmaları genellikle künt travmadan kaynaklanır. Yaşamı tehdit eden miktarda kan kaybı olmadıkça cerrahi müdehale endikasyonu doğmaz. Genellikle derin göğüslü köpek ırklarında mide dilatasyonu ve volvulusa bağlı olarak karşılaşılan ve akut bir dalak hastalığı olan dalak torsiyonun tanısı oldukça zordur. Bu durumda total splenektomi, dalak derotasyonundan ziyade tercih edilen tedavi seçeneğidir. Postoperatif erken dönem komplikasyonları, pankreas ve mide duvarında kanama, kardiyak aritmi ve iskemiyi içerir; postoperatif seyrin komplikasyonları olarak metastaz ve mide dilatasyonu ve volvulus görülür. Bu derleme, bir organ olarak dalağın fonksiyonel önemini ve işlevlerini daha iyi anlamak için yeni bir kapı açmayı, tanı araçları hakkında bilgiler paylaşmayı ve hastalıklarında uygun cerrahi yaklaşımın seçilmesine rehberlik etmeyi amaçlamıştır.

An Overlooked Entities in Small Animal Surgery: Splenic Disorders

The spleen, which has a vitally important function in the body, is located in the left part of the abdomen. The spleen’s primary tasks are hematopoiesis and immunity, such as the reservoir of blood cells and the production of the immune system’s defense cells. On most occasions -due to the lack of clinical manifestation- splenic disorders are coincidental findings at surgery despite their prevalence. Splenosis is a heterotopic autotransplantation of splenic tissue in other body compartments, which may be interpreted as a pathological entity through imaging techniques. Foreign substance accumulation, such as iron deposition, namely siderosis, may be monitored in the spleen due to the aging process. The pathologies of the spleen are mostly characterized by the enlargement of the organ (splenomegaly). Hemangiosarcoma is the most frequently encountered neoplasia in the spleen, usually metastasizing to the heart’s right atrium. Ultrasonography is the most commonly utilized diagnostic tool in splenic disorders. Besides, the magnetic resonance imaging (MRI) and computed tomography (CT) techniques may be applied. Whole blood, plasma, or both are prerequisites that should be kept at disposal in the preoperative approach to the splenic disorders. Surgical interventions of splenic pathologies include splenorrhaphy, partial splenectomy, and total splenectomy. Splenic injuries usually result from blunt trauma. Surgery is not an indication unless there is a life-threatening amount of blood loss. Splenic torsion, which is an acute disorder of the spleen usually encountered in deep-chested dog breeds due to gastric dilatation and volvulus presents a diagnostic challenge. Total splenectomy is the favored treatment of choice in the approach of the relevant conditions rather than splenic derotation. Early phase complications include hemorrhage, cardiac arrhythmia, and ischemia in the pancreas and gastric wall, and metastasis and gastric dilatation and volvulus appear as the complications of the postoperative course. This review has aimed to open a new gate to better understanding the importance and functions of the spleen in normal physiology and also aimed to share information about the diagnostic tools and guide through to apply appropriate surgical approach in term of discorders.

___

  • 1. Bezuidenhout AJ: The lymphatic system. In, Hermanson J, Lahunta A (Eds): Miller’s Anatomy of the Dog. 5th ed., 644, WB Saunders, Philedelphia, 2019.
  • 2. Dyce KM, Sack WO, Wensing CJ: Textbook of Veterinary Anatomy, 5th ed., Saunders, Philedelphia, 2017.
  • 3. Fife WD, Samii VF, Drost WT, Mattoon JS, Hoshaw-Woodard S: Comparison between malignant and non malignant splenic masses in dogs using contrast-enhanced computed tomography. Vet Radiol Ultrasound, 45 (4): 289-297, 2004. DOI: 10.1111/j.1740-8261.2004.04054.x
  • 4. Richer MC: Spleen. In, Tobias KM, Johnston SA (Eds): Veterinary Surgery, Small Animal, Vol. 2, 1551-1564, Elsevier - Saunders, St. Louis, 2018.
  • 5. Awal MA, Asaduzzaman M, Anam MK, Prodhan MAA, Kurohmaru M: Arterial supply to the stomach of indigenous dog (Canis familiaris) in Bangladesh. Exp Anim, 50 (4): 349-352, 2001. DOI: 10.1538/expanim.50.349
  • 6. Bloom E, Fawcett DW: A Textbook of Histology, 8th ed., Saunders, Philadelphia, 1986.
  • 7. Gaunt SD: Hemolytic anemias caused by blood rickettsial agents and protozoa. In, Feldman BF, Zinkl JG, Jain NC (Eds): Schalms’ Veterinary Hematology. 5th ed., 154, Lippincott Williams & Wilkins, Philadelphia, 2000.
  • 8. Spangler WL, Culbertson MR: Prevalence and type of splenic diseases in cats: 455 cases (1985-1991). J Am Vet Med Assoc, 201 (5): 773-776, 1992b.
  • 9. Hottendorf GH, Hirth RS: Lesions of spontaneous subclinical disease in beagle dogs. Vet Pathol, 11 (3): 240-258, 1974. DOI: 10.1177/ 030098587401100306
  • 10. Brisson BA: Spleen. In, Monnet E, Bojrab MJ (Eds): Disease Mechanisms in Small Animal Surgery, 3rd ed., 616, Teton-NewMedia, Jackson, 2010.
  • 11. Boes KM, Durham AC: Bone marrow, blood cells, and lymphatic system. In, Zachary JF (Ed): Pathologic Basis of Veterinary Disease. 6th ed., 780-788, Elsevier St Louis, 2017.
  • 12. Robertson JL, Newman SJ: Disorders of the spleen. In, Feldman BF, Zinkl JG, Jain NC (Eds): Schalms’ Veterinary Hematology, 5th ed., 272, Lippincott Williams & Wilkins, Philadelphia, 2000.
  • 13. Hanson JA, Papageorges M, Girard E, Menard M, Hebert P: Ultrasonographic appearance of splenic disease in 101 cats. Vet Radiol Ultrasound, 42 (5): 441-445, 2001. DOI: 10.1111/j.1740-8261.2001.tb00967.x
  • 14. Elders R: Haematological parameters in dogs presenting with malignant and benign splenic lesions. Proceedings of the 21st Annual Forum of the American College of Veterinary Internal Medicine, 2003.
  • 15. Ward PM, McLauchlan G, Millins C, Mullen D, McBrearty AR: Leishmaniosis causing chronic diarrhoea in a dog. Vet Rec Case Rep, 7:e000768, 2019. DOI: 10.1136/vetreccr-2018-000768
  • 16. Maheshwarappa YP, Patil SS, Swapna CR, Chandrashekarappa M, Kotresh AM, Pradeep BS: Therapeutic management of ehrlichiosis in German Shepherd Dog: A Case Report. Int J Curr Microbiol Appl Sci, 9 (3): 2440-2444, 2020.
  • 17. Meléndez-Lazo A, Ordeix L, Planellas M, Pastor J, Solano-Gallego L: Clinicopathological findings in sick dogs naturally infected with Leishmania infantum: Comparison of five different clinical classification systems. Res Vet Sci, 117, 18-27, 2018. DOI: 10.1016/j.rvsc.2017.10.011
  • 18. Aroch I, Ofri R, Baneth G: Concurrent epistaxis, retinal bleeding and hypercoagulability in dog with visceral leishmaniosis. Israel J Vet Med, 72 (4): 39-48, 2017.
  • 19. Geiger J, Morton BA, Vasconcelos EJR, Tngrian M, Kachani M, Barrón EA, Gavidia CM, Gilman RH, Angulo NP, Lerner R, Scott T, Mirrashed NH, Oakley B, Diniz PPVP: Molecular characterization of tandem repeat protein 36 gene of Ehrlichia canis detected in naturally infected dogs from Peru. Am J Trop Med Hyg, 99 (2): 297-302, 2018, DOI: 10.4269/ajtmh.17-0776
  • 20. DeGroot W, Giuffrida MA, Rubin J, Runge JJ, Zide A, Mayhew PD, Culp WTN, Mankin KT, Amsellem PM, Petrukovic B, Ringwood PB, Case JB, Singh A: Primary splenic torsion in dogs: 102 cases (1992-2014). J Am Vet Med Assoc, 248 (6): 661-668, 2016. DOI: 10.2460/javma.248.6.661
  • 21. Matos AJF, Duarte S, Lopes C, Lopes JM, Gartner F: Splenic hamartomas in a dog. Vet Rec, 161, 308-310, 2007. DOI: 10.1136/vr.161.9.308
  • 22. Leyva FJ, Loughin CA, Dewey CW, Marino DJ, Akerman M, Lesser ML: Histopathologic characteristics of biopsies from dogs undergoing surgery with concurrent gross splenic and hepatic masses: 125 cases (2012–2016). BMC Res Notes 11 (1):122, 2018. DOI: 10.1186/s13104-018- 3220-1
  • 23. Gärtner F, Schmitt F, Santos M, Gillette D: Inflammatory pseudotumor of the spleen in a dog. Vet Rec, 150, 697-698, 2002. DOI: 10.1136/vr.150.22.697
  • 24. Culp WTN, Aronson LR: Splenic foreign body in a cat. J Feline Med Surg, 10 (4): 380-383, 2008. DOI: 10.1016/j.jfms.2007.12.005
  • 25. Larson MM: The liver and spleen. In, Thrall DE (Ed): Textbook of Veterinary Diagnostic Radiology. 7th ed., 792, Saunders, St. Louis, 2017.
  • 26. Salgueiro NBM, Junior ACCL, Tavares ACG, de Souza Santos MA: Sonographic aspects of splenic torsion due to abdominal eventration in a dog. Acta Sci Vet, 45 (Suppl. 1): 197, 2017.
  • 27. Neath PJ, Brockman DJ, Saunders HM: Retrospective analysis of 19 cases of isolated torsion of the splenic pedicle in dogs. J Small Anim Pract, 38 (9): 387-392, 1997. DOI: 10.1111/j.1748-5827.1997.tb03491.x
  • 28. Radlinsky M, Fossum TW: Surgery of Hemolympatic System, In, Fossum TW (Ed): Small Animal Surgery, 5th ed., 631, Elsevier/Mosby, St Louis, 2019.
  • 29. Rossi F, Leone VF, Vignoli M, Laddaga E, Terragni R: Use of contrast enhanced ultrasound for characterization of focal splenic lesions. Vet Radiol Ultrasound, 49 (2): 154-164, 2008. DOI: 10.1111/j.1740- 8261.2008.00343.x
  • 30. Mangano C, Macrì F, Di Pietro S, Pugliese M, Santoro, S, Iannelli NM, Mazzullo G, Crupi R, De Majo M: Use of contrast enhanced ultrasound for assessment of nodular lymphoid hyperplasia (NLH) in canine spleen. BMC Vet Res, 15:196, 2019. DOI: 10.1186/ s12917-019- 1942-5
  • 31. Hughes JR, Szladovits B, Drees R: Abdominal CT evaluation of the liver and spleen for staging mast cell tumors in dogs yields nonspecific results. Vet Radiol Ultrasound, 60 (3): 306-315, 2019. DOI: 10.1111/vru.12717
  • 32. Sutil DV, Mattoso CR, Volpato J, Weinert N C, Costa, Á, Antunes RR, Muller TR, Beier SL, Tochetto R, Comasetto F, Saito ME: Hematological and splenic Doppler ultrasonographic changes in dogs sedated with acepromazine or xylazine. Vet Anaesth Analg, 44 (4): 746-754, 2017. DOI: 10.1016/j.vaa.2016.11.012
  • 33. Kutara K, Seki M, Ishigaki K, Teshima K, Ishikawa C, Kagawa Y, Edamura K, Nakayama T, Asano K: Triple-phase helical computed tomography in dogs with solid splenic masses. J Vet Med Sci, 79 (11): 1870- 1877, 2017. DOI: 10.1292/jvms.17-0253
  • 34. Hwang Y, Noh D, Choi S, Choi H, Lee Y, Lee K: Changes of ultrasonographic pattern of the spleen examined with a high‐frequency linear transducer during growth in puppies. Vet Radiol Ultrasound, 61, 577-582, 2020. DOI: 10.1111/vru.12873
  • 35.Day MJ, Lucke VM, Pearson H: A review of pathological diagnoses made from 87 canine splenic biopsies. J Small Anim Pract, 36 (10): 426- 433, 1995.
  • 36. Ramani M, Reinhold C, Semelka RC, Siegelman ES, Liang L, Ascher SM, Brown JJ, Eisen RN, Bret PM: Splenic hemangiomas and hamartomas: MR imaging characteristics of 28 lesions. Radiology, 202 (1): 166-172, 1997. DOI: 10.1148/radiology.202.1.8988207
  • 37. Reddy S, Reddy S: Hemangiosarcoma of the spleen: Helical computed tomography features. South Med J, 93 (8): 825-827, 2000.
  • 38. Héry G, Becmeur F, Méfat L, Kalfa D, Lutz P, Lutz L, Guys JM, de Lagauise P: Laparoscopic partial splenectomy: Indications and results of a multicenter retrospective study. Surg Endosc, 22, 45-49, 2008. DOI: 10.1007/s00464-007-9509-0
  • 39. Fremont RD, Rice TW: Splenosis: A review. South Med J, 100 (6): 589- 593, 2007. DOI: 10.1097/SMJ.0b013e318038d1f8
  • 40. Buracco P, Massari F: Splenectomy. In, Griffon D, Hamaide A (Eds): Complications in Small Animal Surgery. 401-409, Wiley&Sons, Iowa, 2015.
  • 41. Spangler WL, Kass PH: Pathologic factors affecting postsplenectomy survival in dogs. J Vet Intern Med, 11 (3): 166-171, 1997. DOI: 10.1111/ j.1939-1676.1997.tb00085.x
  • 42. Story AL, Wavreille V, Abrams B, Egan A, Cray M, Selmic LE: Outcomes of 43 small breed dogs treated for splenic hemangiosarcoma. Vet Surg, 49 (6): 1154-1163, 2020 DOI: 10.1111/vsu.13470
  • 43. Bray JP, Orbell G, Cave N. Munday JS: Does thalidomide prolong survival in dogs with splenic haemangiosarcoma? J Small Anim Pract, 59 (2): 85-91, 2018. DOI: 10.1111/jsap.12796
  • 44. Mackenzie G, Barnhart M, Kennedy S, DeHoff W, Schertel E: A retrospective study of factors influencing survival following surgery for gastric dilatation-volvulus syndrome in 306 dogs. J Am Anim Hosp Assoc, 46 (2): 97-102, 2010. DOI: 10.5326/0460097
  • 45. Sartor AJ, Bentley AM, Brown DC: Association between previous splenectomy and gastric dilatation-volvulus in dogs: 453 cases (2004- 2009). J Am Vet Med Assoc, 242 (10): 1381-1384, 2013. DOI: 10.2460/javma. 242.10.1381
  • 46. Song KK, Goldsmid SE, Lee J, Simpson DJ: Retrospective analysis of 736 cases of canine gastric dilatation volvulus. Aust Vet J, 98, 232-238, 2020. DOI: 10.1111/avj.12942
  • 47. Maki LC, Males KN, Byrnes MJ, El-Saad AA, Coronado GS: Incidence of gastric dilatation-volvulus following a splenectomy in 238 dogs. Can Vet J, 58 (12): 1275-1280, 2017.
  • 48. Paravicini PV, Gates K, Kim J: Gastric dilatation organoaxial volvulus in a dog. J Am Anim Hosp Assoc, 56 (1): 42-47, 2020. DOI: 10.5326/JAAHAMS-6733
  • 49. Angelou V, Chatzimisios K, Patsikas M, Psalla D, Papazoglou LG: Omental torsion associated with splenic torsion in a dog. Vet Rec Case Rep, 8 (3): e001153, 2020 DOI: 10.1136/vetreccr-2020-001153
Kafkas Üniversitesi Veteriner Fakültesi Dergisi-Cover
  • ISSN: 1300-6045
  • Yayın Aralığı: Yılda 6 Sayı
  • Başlangıç: 1995
  • Yayıncı: Kafkas Üniv. Veteriner Fak.
Sayıdaki Diğer Makaleler

Ratlarda Oluşturulan Mezenterik Arter İskemisinin Erken Belirteçleri

Feray AYDIN, Bilge ASLAN

Enfektif Hastalıklarda Oksidan ve Antioksidan Parametrelerin Rolü: Sistematik Bir Literatür Değerlendirmesi

Sena ÇENESİZ

Chlamydophila abortus Kaynaklı Enzootik Koyun Abortlarının Başarılı Yönetimi: Şavşat Örneği (Türkiye)

Emin KARAKURT, Serpil DAĞ, Ediz Kağan ÖZGEN, Murat ÖZMEN, Elif KARADENİZ PÜTÜR, Mustafa ULUCAN, Hilmi NUHOĞLU, Fatih BÜYÜK, Aliye GÜLMEZ SAĞLAM, Elif ÇELİK, Mustafa Reha COŞKUN, Eray BÜYÜK, Mitat ŞAHİN

Efficacy and Toxicity of Doxorubicin and Cyclophosphamide for the Neoadjuvant Treatment of Locally Advanced Stage Canine Mammary Tumors

Fikriye Ecem KURUOĞLU, Musa Özgür ÖZYİĞİT, Deniz NAK, Zehra AVCI KÜPELİ, Zeynep Merve EKİCİ, Davut KOCA, Talha AVCILAR, Mustafa Eren ŞAHİN, Yavuz NAK, Abid Hussain SHAHZAD

Polymorphisms in Some Candidate Genes Associated with Egg Yield and Quality in Five Different White Layer Pure Lines

Eymen DEMİR, Taki KARSLI, Hüseyin Göktuğ FiDAN, Bahar Argun KARSLI, Mehmet ASLAN, Sedat AKTAN, Serdar KAMANLI, Kemal KARABAĞ, Emine ŞAHİN SEMERCİ, Murat BALCIOĞLU

Klorojenik Asit ve Rhabdosciadium anatolyi’nin Siklofosfamid İle Ratlarda Oluşturulan Ovaryum Toksisitesine Karşı Koruyucu Etkisinin Histopatolojik ve İmmunohistokimyasal Bulgularla Değerlendirilmesi

Mehmet FIRAT, Suat EKİN, İsmet ALKIŞ, Ahmet BAKIR, Gizem ESER, Serkan YILDIRIM

The Role of Oxidant and Antioxidant Parameters in the Infectious Diseases: A Systematic Literature Review

Sena ÇENESİZ

Effect of Resveratrol Supplemented to Japanese Quail (Coturnix coturnix japonica) Rations on Performance and Some Biochemical Parameters

Mükremin ÖLMEZ, TARKAN ŞAHİN, Mustafa MAKAV, Özlem KARADAĞOĞLU

Dystocia Caused by Spinal Paraplegia in a Cat with Superfetation

Hilal ACAR, Barış GÜNER, Volkan İPEK

Evaluation of the Protective Effect of Chlorogenic Acid and Rhabdosciadium anatolyi Against Cyclophosphamide-Induced Ovarian Toxicity in the Rat with Histopathological and Immunohistochemical Findings

İsmet ALKIŞ, Suat EKİN, Serkan YILDIRIM, Ahmet BAKIR, Gizem ESER, Mehmet FIRAT