The Role of Oxidant and Antioxidant Parameters in the Infectious Diseases: A Systematic Literature Review

The formation of reactive oxygen species is a physiological event in aerobic life. In case of infection, if the increased oxidant substances cannot be cleaned sufficiently by antioxidants, oxidative stress occurs. As a result, a number of pathological problems occur by damaging DNA, protein, carbohydrate and lipids. In biological systems, the balance between oxidants and antioxidants is important. In oxidative stress situations where the balance cannot be achieved sufficiently, support can be provided with the use of exogenous antioxidants. However, the molecular structure, route of administration and concentrations of these exogenous antioxidants are important. Otherwise, they may show a pro-oxidative effect. The present rewiev study makes a general overview of oxidative-nitrosative stress markers commonly used in infective clinical studies, antioxidant enzymes and parameters and antioxidant supplements.

Enfektif Hastalıklarda Oksidan ve Antioksidan Parametrelerin Rolü: Sistematik Bir Literatür Değerlendirmesi

Reaktif oksijen türlerinin oluşumu arerobik yaşamda fizyolojik bir olaydır. Bu serbest radikal türlerinin daha fazla üretilmesine neden olan paraziter, bakteriyel ve viral enfeksiyonlarda antioksidan sistemin kapasitesi bu reaktifleri yeterince temizleyemez ise oksidatif stres gelişir. Sonuçta DNA, protein, karbonhidrat ve lipidlerde hasar oluşarak bir takım patolojik problemler meydana gelir. Biyolojik sistemlerde oksidan ve antioksidanlar arasındaki denge önemlidir. Dengenin yeterince sağlanamadığı oksidatif stres durumlarında bazan eksojen antioksidan kullanımı ile destek sağlanabilir. Ancak bu eksojen antioksidanların molekül yapısı, veriliş yolu ve konsantrasyonları önemlidir. Aksi takdirde pro-oksidatif etki gösterebilirler. Bu çalışma ile yaygın olarak görülen enfektif klinik çalışmalarda kullanılan oksidatif-nitrozatif stres belirteçlerinin, antioksidan enzim ve parametreleri ile ileriye yönelik olarak yapılacak bazı antioksidan supplementlerinin genel bir durumu değerlendirilmiştir.

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Kafkas Üniversitesi Veteriner Fakültesi Dergisi-Cover
  • ISSN: 1300-6045
  • Yayın Aralığı: Yılda 6 Sayı
  • Başlangıç: 1995
  • Yayıncı: Kafkas Üniv. Veteriner Fak.
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