Murat FINDIK, Duygu KAYA, Serhan Serhat AY, Firdevs ÖNYAY, Gülşah SARAL, Selim ASLAN

Kedilerde Orta Dönem Gebeliklerin Sonlandırılmasında Aglepriston ve Cabergolinin Tek Başlarına veya Birlikte Uygulanmasının Etkinliği

Bu çalışmada kedilerde orta dönem gebeliklerin sonlandırılmasında aglepriston ve cabergolin kombinasyonunun etkinliği belirlendi. Çalışmada istenmeyen gebeliği olan ve gebeliğin 30-40. günleri arasında olan 20 kedi kullanıldı. AGL grubuna (n=6) aglepriston (10 mg/kg, sc) 24 saat arayla iki defa uygulandı. CBG grubuna (n=7) cabergolin (5 μg/kg, peros) abortuslar başlayana kadar veya 8 gün süreyle günlük olarak uygulandı. AGL+CBG (n=7) grubuna ise her iki ilaç birlikte verildi. AGL grubunda kedilerin %50’sinde, CBG grubunda %71.4’ünde ve AGL+CBG grubunda ise %100’ünde abortuslar şekillendi. Bununla birlikte AGL+CBG grubundaki bir kedide fetal retensiyondan dolayı gebelik sonlanma oranı %85.7 olarak şekillendi. Tedavi-abortus başlama aralığı (T-SA) AGL+CBG grubunda (3.6±0.3 gün) AGL (6.5±0.0) ve CBG (6.2±0.2) gruplarından daha kısa bulundu (P

The Efficacy of Alone or Combined Treatment of Aglepristone and Cabergoline on Termination of Mid-term Pregnancy in Cats

This study determined the efficacy of a combination of aglepristone and cabergoline on termination of mid-term cat pregnancies. Twenty cats withunwanted pregnancies between 30-40 days were included in the study. Aglepristone (10 mg/kg, sc) was given to the AGL group (n=6) twice in a24-h interval. Cabergoline (5 μg/kg, peros) was administered to the CBG group (n=7) once daily until abortion started or for 8 days. AGL+CBG (n=7)received a combined treatment with both drugs. Abortion occurred in 50% of cats in the AGL group, 71.4% in the CBG group, and 100% in theAGL+CBG. However, the completion of pregnancy termination rate was 85.7% because of fetal retention in one cat from the AGL+CBG group.The interval between treatment-start of abortion (T-SA) was shorter in the AGL+CBG group (3.6±0.3 days) than in the AGL (6.5±0.0) and CBG(6.2±0.2) groups (P

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