AYSEL GÜVEN, Serpil ERGİNSOY, NECATİ KAYA

Kazlarda karobn tetraklorür zehirlenmesinin biyokimyasal ve patolojik parametrelere etkisi

Bu çalışmada karbon tetraklorür (CC14) ile karaciğer dejenerasyonu oluşturulan kazlarda lipid peroksidasyonunun (LPO) göstergesi olan malondialdehid (MDA) ve serum total lipid, total protein, albumin, glukoz, üre, ürik asit, kolesterol, kalsiyum, inorganik fosfat, sodyum ve potasyum düzeylerindeki değişiklikler incelenerek dejenerasyon ile olan ilişkileri araştırıldı. Karaciğer dejenerasyonu, ortalama 3 haftalık kaz palazlarına 10 hafta süre ile haftada 3 kez (2 ml/kg vücut ağırlığı olacak şekilde) CCl4'ün oral olarak verilmesiyle oluşturuldu. CC14 uygulanan grupta plazma MDA düzeyleri kontrol grubuna göre yüksek (P< 0,01) bulundu. Kontrol ve deneme grubun üre, ürik asit, albumin, Na ve K düzeylerinde 5 ve 10. haftalarda alman örneklerde önemli bir farklılık gözlenmezken, total protein, total lipid, kalsiyum inorganik fosfat ve potasyum oranlarında artış, kolesterol ve glukoz düzeyinde ise önemli oranda düşjiş (P

Anahtar Kelimeler:

üre, kaz, lipit, karaciğer, patoloji, kümes hayvanları, protein, kolesterol, ürik asit, biyokimyasal parametreler, karbon tetraklorür

The effects, of carbon tetrachlorür poison on the biochemical and pathologic parameters as a result of lipid perowidation in geese

Changes in the level of malondialdehyde (MDA, a degradative product of lipid peroxidation) and the levels of serum, total lipid, total proteine, albumin, glucose, ure, uric acid, cholesterol, calcium, inorganic phosphete, sodium, potasium in geese with carbon tetrachloride-induced liver degeranation were studied, in order to determine whether there is any relation between these parameters and the degeranation. Liver degeration was induced in geese by carbon tetrachloride (2 ml/kg body weight) Which was oral-pathway three times a week for ten weeks. Malondialdeyide content of the plasma was higher than the control value at the first sampling (P<0.01) 5. week after treatment and decreased to the control level there after. No significant changes were found ure, uric acid albumin, Na and K levels between at the first 5 and 10th week sampling. The level of serum total protein, total lipid, inorganic phosphere Ca in the group with degerations were significantly higher than in the control group (P< 0.01). The lipid peroxidation of every parameter was seen as logical in terms of statistical (P<0.05). Under microscopic examination hydropic and fat degeneration of the liver were observed and the skeleton system was seen to be completely deformed with the bones twisted, in part. Thus, we consider that cirhosis causes changes lead to oxidative stress and peroxidation and it can blood serum of geese biochemical parameters.

Keywords:

urea, geese, lipids, liver, pathology, poultry, protein, cholesterol, uric acid, biochemical parameters, carbon tetrachloride,

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