MUTALİP ÇİÇEK, Osman EVLİYAOĞLU, Abdullah BÖYÜK, Alicem TEKİN

Investigation of Some Sera Biomarker Levels in Fascioliasis Patient

Çoğunlukla koyun ve sığırların karaciğer trematodu olarak bilinen Fasciola sp. insanlarda da enfeksiyon oluşturmaktadır. Bu çalışmada, fascioliasisli hastaların serumlarında Paraoxonase, Total oksidan seviye, Total antioksidan kapasite, Apolipoprotein A, Apolipoprotein B, Transferin ve Nitrik oksit düzeylerinin nasıl etkilendiği araştırıldı. Bu amaçla çalışmaya 45 fascioliasisli hasta ve 38 sağlıklı bireylerden oluşan kontrol grubu dâhil edildi. Fascioliasisli hastalar ELISA IgG, dışkı bakısı ve radyolojik görüntüleme ile teşhis edildi. Hasta ve kontrol grubunda kadın ve erkek sayıları sırasıyla 34/11ve 30/8 olarak belirlendi. Ortalama yaş hasta grubunda 38.1±11.7, kontrol grubunda ise 35.8±16.9 idi. İki grup arasında yaş, cinsiyet ve vücut kitle indeksi açısından istatistik olarak farklılık saptanmadı (P>0.05). Bu çalışma sonucunda fascioliasisli hastalarda Paraoxonase (P

Fascioliasisli Hastalarda Bazı Serum Biyomarkır Düzeylerinin Araştırılması

Fasciola sp. that are generally known as liver trematode of sheep and cattle cause infections also in the human. In this study, we investigated in the sera of patients with fascioliasis how paraoxonase, total oxidant level, total antioxidant capacity, apolipoprotein A-I, apolipoprotein B, transferrin and nitric oxide levels are affected. For this purpose, 45 patients with fascioliasis and 38 healthy controls were enrolled in the study. Fascioliasis was diagnosed with ELISA IgG, stool examination and radiologic imaging. Number of females and males were determined as 34/11 and 30/8 in patient and control groups. Mean age was 38.1±11.7and 35.8±16.9 years in patient and control groups, respectively. A statistically significant difference was not detected between groups in terms of age, gender and body mass index (P>0.05). As the result of the study, paraoxonase (P<0.001), Apolipoprotein A-I (P<0.001), transferrin (P<0.001) and total antioxidant capacity (P<0.024) levels were found lower in patient group compared to control group and the difference was statistically significant (P<0.001). A difference was not detected between two groups in terms of apolipoprotein B levels. Lower paraoxonase, total antioxidant capacity, transferrin and Apolipoprotein A-I levels in patients with fascioliasis compared to controls and higher nitric oxide and total oxidant status may be guide for understanding pathogenesis and immunity of fascioliasis and for novel biomarkers that could aid for diagnosis

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