İBRAHİM RENCÜZOĞULLARI, YAVUZ KARABAĞ, METİN ÇAĞDAŞ, YASEMEN ADALI, Süleyman KARAKOYUN, EKİN EMRE ERKILIÇ, MAHMUT YESİN, FATİH MEDETALİBEYOĞLU, İnanç ARTAÇ, DOĞAN İLİŞ, UĞUR AYDIN

Impact of Supplementation with Branched Chain Amino Acids on Myocardium and Coronary in Regularly and Intensively Exercising Rats

This study was conducted to investigate the effects of branched chain amino acids (BCAAs) consumption on myocardium and coronary arteries, in rats subjected to regular and intense exercise. Eight-week old, 30 male rats were randomly divided into experimental- and controlgroups. For a total of 8 weeks, every other day, both groups were subjected to a ladder-climbing exercise on a 1.5 m long ladder, with 2.5 cm steps interval, at 70 degrees angle. The experimental group, besides the standard diet, was additionally fed BCAA-supplement at a dose of 1.5 mg/g/day. This study showed that, the experimental group had more frequent atherosclerotic lesions compared to the control group (61.5% vs. 21.4%; p=0.034). Although creatine kinase was similar between the groups, creatine kinase - myocardial band isoform (CK-MB) was significantly higher in the experimental group compared both to control and baseline levels. This is the first study that examines the effects of consuming BCAA supplements on myocardium and coronary arteries in rats subjected to prolonged exercise. We demonstrated that continuous and long-term consumption of BCAA supplement in endurance exercises was associated with coronary atherosclerotic process and myocardial injury.

Düzenli ve Yoğun Egzersiz Yaptırılan Ratlarda Takviye Olarak Tüketilen Dallı Zincirli Amino Asitlerin Miyokard ve Koroner Damarlar Üzerine Etkisi

Bu çalışmada, düzenli ve yoğun olarak egzersiz yaptırılan ratlarda, dallı zincirli amino asit (BCAA) kullanımının miyokard ve koroner arterlere etkisi araştırılmıştır. Sekiz haftalık, 30 erkek rat rastgele deneysel ve kontrol gruplarına ayrıldı. Her iki grup, günaşırı periyotla, 2.5 cm basamak aralığı olan, 1.5 metre uzunluğunda 70 derecelik açıyla duran bir merdiven üzerinde, toplam 8 hafta boyunca, tırmanma egzersize tabi tutuldu. Deney grubu, standart diyete ek olarak BCAA takviyesi ile 1.5 mg/g/gün dozunda beslendi. Çalışma sonunda, deney grubunda, kontrol grubuna göre daha sık aterosklerotik lezyonları vardı (%61.5’e karşı %21.4; P=0.034). Ayrıca, kreatin kinaz, gruplar arasında benzer izlendiyse de, kreatin kinaz-miyokardiyal band izoformu (CK-MB) deney grubunda, hem kontrol, hem de başlangıç düzeylerine kıyasla belirgin olarak daha yüksekti. Bu, BCAA tüketen ve uzun süre egzersize tabi tutulan ratlarda, BCAA takviyesi tüketiminin miyokard ve koronerlere etkilerini inceleyen ilk çalışmadır. Bu çalışma zorlu egzersizle beraber, devamlı ve uzun süreli BCAA tüketiminin, koroner aterosklerotik süreç ve miyokardiyal hasar ile ilişkili olduğu gösterdi.

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