EBRU KARADAĞ SARI, Mümtaz NAZLI, Hakan KOCAMIŞ, Nurhayat GÜLMEZ, ŞAHİN ASLAN, TURGAY DEPREM

Immunohistochemical localization of serotonin-, gastrin-,and somatostatin-immunoreactive endocrine cells in the duodenum of the rat (Wistor albino)

Gastrointestinal hormonların bir çoğu ince barsaklarda, özellikle de duodenum mukozasında üretilir. Bu çalışmanın amacı, rat duodenumunda serotonin, gastrin ve somatostatine karşı antikorlar kullanarak immunohistokimyasal yöntemlerle serotonin-, gastrin-, ve somatostatin-immunoreaktif hücrelerin dağılımının incelenmesidir. Rat duodenumunda çok sayıda serotonin-immunoreaktif hücre ile çok az sayıda gastrin-, ve somatostatin-immunoreaktif hücre görüldü.

Anahtar Kelimeler:

somatostatin, hücre, immünohistokimya, serotonin, gastrin, onikiparmak bağırsağı, sıçan, endokrinoloji

Serotonin-, gastrin-, ve somatostatin-imunoreaktif endocrin hücrelerin rat (Wistor albino) duodenumunda immunohistokimyasal lokalizasyonu.

Most of the gastrointestinal hormones are produced in the small intestine particularly in the duodenal mucosa. The objective of the current study was to investigate the distribution of the serotonin-, gastrin-, and somatostatin-immunoreactive endocrine cells in the duodenum of rat by immunohistochemical techniques using antisera against serotonin, gastrin, and somatostatin. Numerous serotonin-immunoreactive cells, and very few gastrin-, and somatostatin-immunorective cells were seen in the rat duodenum.

Keywords:

somatostatin, cells, immunohistochemistry, serotonin, gastrin, duodenum, rats, endocrinology,

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