ŞÜKRÜ METİN PANCARCI, CİHAN KAÇAR, Örsan GÜNGÖR, HASAN ORAL, METİN ÖĞÜN, MAHMUT KARAPEHLİVAN, KUTLAY GÜRBULAK, Mehmet ÇİTİL

Effect of L-carnitine administration on energy metabolism during periparturient period in ewes

Peripartum dönemdeki yağlı kuyruklu koyunlarda L-Karnitinin enerji metabolizması üzerine etkisi iki çalışmayla araştırıldı. Birinci çalışmadaki gebe koyunlara L-Karnitin (1 g/50 kg, uygulama I, n=8) veya fizyolojik tuzlu su (uygulama II; n=8) subkutan yolla haftada bir kez doğuma kadar toplam yedi-sekiz hafta süresince enjekte edildi. İkinci çalışmadaki gebe koyunlara L-Karnitin (0.5 g/50 kg, uygulama I, n=6) veya fizyolojik tuzlu su (uygulama II; n=5) subkutan yolla haftada iki kez doğuma kadar en az üç hafta süreyle enjekte edildi. Uygulamalar süresince ve doğumdan sonraki hafta serumdaki serbest yağ asit (NEFA), β-hidroksibutirik asit (BHBA), toplam trigliserit ve glikoz konsantrasyonlarını belirlemek amacıyla kan örnekleri alındı. Birinci çalışmada, serum NEFA konsantrasyonu doğuma kadar önemli derecede (P

Anahtar Kelimeler:

yağ asitleri, glukoz, kuzulama, doğum öncesi dönem, biyokimyasal parametreler, kan şekeri, karnitin, enerji metabolizması, koyunlar

Koyunlarda periparturient dönemde L-Karnitin uygulamasının enerji metabolizması üzerine etkisi.

Two experiments were conducted to investigate the effect of L-Carnitine administration on energy metabolism during periparturient period in fat tailed ewes. In Experiment I, L-Carnitine (1 g/50 kg, Treatment I, n=8) and physiologic saline (Treatment II; n=8) were administered subcutaneously weekly until lambing for seven or eight weeks. In Experiment II, L-Carnitine (0.5 g/50 kg, Treatment I, n=6) and physiologic saline (Treatment II; n=5) administered subcutaneously twice a week until lambing for at least three weeks. Blood samples were collected during treatments and one week after lambing to determine serum non esterified faty acid (NEFA), β-hidroxybutiric acid (BHBA), total triglyceride and glucose concentrations. In experiment I, NEFA concentrations significantly (P<0.01) increased until parturition followed by sudden decrease, and the concentrations were significantly lower (P<0.01) in L-Carnitine group. In Experiment II, serum NEFA concentrations were significantly (P<0.01) lower at and one week prior to lambing in ewes treated with more than four weeks compared to those treated with four or less than four weeks prepartum. Serum concentrations gradually (P<0.01) increased until parturition followed by sudden decrease in all groups. However, serum NEFA concentrations did not differ in Experiment II. In conclusion, L-Carnitine administration during periparturient period decreased serum NEFA concentrations without any changes in serum BHBA, triglyceride and glucose concentrations.

Keywords:

fatty acids, glucose, lambing, prepartum period, biochemical parameters, blood sugar, carnitine, energy metabolism, ewes,

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