Hannaneh GOLSHAHI, Abbas TAVASOLY, Annahita REZAIE, Mohammad FARHADI

Immunohistochemical and histopathological findings of chondrosarcoma in mammary gland of a dog: A case report

Kondrosarkoma kondrositlerin malignant bir tumörüdür ve en yaygın olarak yassı kemiklerde ve nazal boşlukta oluşur. Meme kondrosarkomu köpeklerde yaygın değildir. Bu makalenin amacı 10 yaşlı dişi bir Alman çoban köpeğinde meme kondrosarkoma olgusunu tanımlamaktır. Sağ torasik meme bezinde 8 ay süresince büyüme gösteren bir kitleye sahip olan köpek Veteriner Hastanesine getirildi. Kitle ile beraber bölgesel lenf yumrusu total mastektomi ile uzaklaştırıldı ve histopatolojik incelemeler için patoloji anabilim dalına gönderildi. Makroskopik olarak kitle 5x4x5 cm boyutunda, içerisinde sert yapılar ihtiva eden fluktuan bir yapıya sahipti. Kesit yüzü sarı renkli olup içerisi grimsi sıvı ile dolu olan pekçok boşluksu yapılar içermekteydi. Mikroskopik incelemede kitlenin lakuna, kondrosit ve kondroblastlardan oluşan geniş olgun kıkırdak yapısında olduğu belirlendi. İmmunohistokimyasal incelemede kitlenin Östrojen reseptör için negative olduğu gözlemlendi. Makroskopik ve mikroskopik bulgular doğrultusunda kitle kondrosarkoma olarak tanımlandı.

Bir köpeğin meme bezinde gözlenen kondrosarkoma olgusunda immunohistokimyasal ve histopatolojik incelemeler: Olgu sunumu

Chondrosarcoma is a malignant tumor of chondrocytes and occurs most commonly on the flat bones and the nasal cavity. Mammary chondrosarcoma is an uncommon tumor in canine practice. The aim of present paper is to report a case of mammary chondrosarcom in a 10-year-old German shepherd bitch. The dog with a mass in her right caudal thoracic mammary gland which grown gradually in 8 months, was referred to the veterinary teaching hospital. The mass and local lymph nodes were resected by complete mastectomy and were sent to department of veterinary pathology for histopathological examination. Macroscopically, the mass was fluctuant containing firm mases in it, totally measuring 5×4×5 cm in diameter. The cross section was yellow and there were many cavernous structures which were filled with grayish fluid. Microscopic examination revealed a mass of large mature cartilage structures with lacunae and chondrocytes and chondroblastes with new forming structures of cartilage. Immonohistochemical investigation revealed that the tumor is negative for Estrogen receptor (ER) expression. According to macroscopic and microscopic investigations chondrosarcoma was diagnosed.

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