Hawthorn (Crataegus oxyacantha) Flavonoid Extract as an Effctive Medicinal Plant Derivative to Prevent Pulmonary Hypertension and Heart Failure in Broiler Chickens

The aim of this study was to investigate the effct of crateagus flvonoid extract in preventing pulmonary hypertension syndrome (PHS) in broiler chickens reared at high altitude, encountered ascites was evaluated. A 225 day-old broiler chickens (Ross-308) were randomly assigned to three treatments including diffrent drinking levels of crateagus flvonoid extract (0, 0.1, and 0.2 mL per liter of drinking water) in a 42-day trial. Body weight gain were increased and feed conversion ratio were decreased significantly (P

Etlik Piliçlerde Pulmoner Hipertansiyon ve Kalp Yetmezliğini Engellemede Etkili Bir Tıbbi Bitki Türü Olarak Alıç (Crataegus oxyacantha) Flavanoid Ekstraktı

Bu çalışmanın amacı, yüksek irtifada yetiştirilen broiler tavuklarında pulmoner hipertansiyon sendromunun (PHS) önlenmesinde alıç flvonoid ekstraktının etkisini araştırmaktır. 42 gün süreli çalışmada, 225 adet 1 günlük broiler tavuk (Ross-308) farklı içme suyu seviyelerindeki alıç flvanoid ekstraktlarına göre (0, 0.1 ve 0.2 mL/L içme suyu) rastgele üç uygulama grubuna ayrıldı. Başlangıç ve büyüme evrelerinde tüm çalışma süresince 0.1 ve 0.2 mL/L içme suyu oranında alıç flvanoid ekstraktı tüketen broiler tavuklarda anlamlı derecelerde vücut ağırlık kazanımı artarken yem konversiyon oranı azaldı (P

___

Ahmadipour B, Hassanpour H, Asadi E, Khajali F, Rafiei F, Khajali F: Kelussia odoratissima Mozzaf - A promising medicinal herb to prevent pulmonary hypertension in broiler chickens reared at high altitude. J Ethnopharmacol, 159, 49-54, 2015. DOI: 10.1016/j.jep.2014.10.043

Khajali F, Fahimi S: Inflence of dietary fat source and supplementary alpha-tocopheryl acetate on pulmonary hypertension and lipid peroxidation in broilers. J Anim Physiol Anim Nutr, 94 (6): 767-772, 2010. DOI: 10.1111/j.1439-0396.2009.00959.x

Behrooj N, Khajali F, Hassanpour H: Feeding reduced-protein diets to broilers subjected to hypobaric hypoxia is associated with the development of pulmonary hypertension syndrome. Br Poult Sci, 53 (5): 658-664, 2012. DOI: 10.1080/00071668.2012.727082

Khajali F, Saedi M: The effct of low chloride and high bicarbonate diets on growth, blood parameters, and pulmonary hypertensive response in broiler chickens reared at high altitude. Archiv für Geflgelkunde, 75, 235- 238, 2011.

Wideman RF, Rhoads DD, Erf GF, Anthony NB: Pulmonary arterial hypertension (ascites syndrome) in broilers: A review. Poult Sci, 92 (1): 64- 83, 2013. DOI: 10.3382/ps.2012-02745

Izadinia M, Nobakht M, Khajali F, Faraji M, Zamani F, Qujeq D, Karimi I: Pulmonary hypertension and ascites as affected by dietary protein source in broiler chickens reared in cool temperature at high altitudes. Anim Feed Sci Technol, 155 (2-4): 194-200, 2010. DOI: 10.1016/j. anifeedsci.2009.12.009

Khajali F, Liyanage R, Wideman RF: Methylglyoxal and pulmonary hypertension in broiler chickens. Poult Sci, 90 (6): 1287-1294, 2011. DOI: 10.3382/ps.2010-01120

Saki A, Haghighat M, Khajali F: Supplemental arginine administered in ovo or in the feed reduces the susceptibility of broilers to pulmonary hypertension syndrome. Br Poult Sci, 54 (5): 575-580, 2013. 10.1080/00071668.2013.811716

Chang Q, Zuo Z, Harrison F, Chow MSS: Hawthorn. J Clin Pharmacol, 42 (6): 605-612, 2002. DOI: 10.1177/00970002042006003

Kirakosyan A, Seymour E, Kaufman PB, Warber S, Bolling S, Chang SC: Antioxidant capacity of polyphenolic extracts from leaves of Crataegus laevigata and Crataegus monogyna (Hawthorn) subjected to drought and cold stress. J Agric Food Chem, 51 (14): 3973-3976, 2003. DOI: 10.1021/jf030096r

Salehi S, Long SR, Proteau PJ, Filtz TM: Hawthorn (Crataegus monogyna Jacq.) extract exhibits atropine-sensitive activity in a cultured cardiomyocyte assay. J Nat Med, 63 (1): 1-8, 2009. DOI: 10.1007/s11418-008-0278-4

Bottje WG, Wideman RF: Potential role of free radicals in the pathogenesis of pulmonary hypertension syndrome. Poult Avian Biol Rev, 6, 211-231, 1995.

Yu BP: Cellular defenses against damage from reactive oxygen species. Physiol Rev, 74 (1): 139-162, 1994. DOI: 10.1152/physrev.1994.74.1.139

Cawthon D, Beers K, Bottje WG: Electron transport chain defect and inefficient respiration may underlie pulmonary hypertension syndrome (ascites)-associated mitochondrial dysfunction in broilers. Poult Sci, 80 (4): 474-484, 2001. DOI: 10.1093/ps/80.4.474

Nain S, Wojnarowicz C, Laarveld B, Olkowski AA: Effcts of dietary vitamin E and C supplementation on heart failure in fast growing commercial broiler chickens. Br Poult Sci, 49 (6): 697-704, 2008. DOI: 10.1080/00071660802415658

Ladmakhi MH, Buys N, Dewil E, Rahimi G, Decuypere E: The prophylactic effect of vitamin C supplementation on broiler ascites incidence and plasma thyroid hormone concentration. Avian Pathol, 26 (1): 33-44, 1997. DOI: 10.1080/03079459708419191

Tekeli A: Effct of rosehip fruit (Rosa canina l.) supplementation to rations of broilers grown under cold stress conditions on some performance, blood, morphological, carcass and meat quality characteristics. Europ Poult Sci, 78, 1612-9199, 2014. DOI: 10.1399/eps.2014.19

Julian RJ: The response of the heart and pulmonary arteries to hypoxia, pressure, and volume. A short review. Poult Sci, 86 (5): 1006-1011, 2007. DOI: 10.1093/PS/86.5.1006

Seevers PM, Daly JM: Studies on wheat stem rust resistance controlled at the Sr6 locus. II. Peroxidase activities. Phytopathology 60 (11): 1642-1647, 1970. DOI: 10.1094/Phyto-60-1642

Chapman ME, Wideman Jr RF: Evaluation of total plasma nitric oxide concentrations in broilers infused intravenously with sodium nitrite, lipopolysaccharide, aminoguanidine, and sodium nitroprusside. Poult Sci, 85 (2): 312-320, 2006. DOI: 10.1093/ps/85.2.312

Nair V, Turner GA: The thiobarbituric acid test for lipid peroxidation: Structure of the adduct with malondialdehyde. Lipids, 19 (10): 804-805, 1984. DOI: 10.1007/bf02534475

Saedi M, Khajali F: Blood gas values and pulmonary hypertension as affcted by dietary sodium source in broiler chickens reared at cool temperature in a high-altitude area. Acta Vet Hung, 58 (3): 379-388, 2010. DOI: 10.1556/AVet.58.2010.3.10

Rehman ZU, Worku T, Davis JS, Talpur HS, Bhattarai D, Kadariya I, Hua G, Cao J, Dad R, Farmanullah, Hussain T, Yang L: Role and mechanism of AMH in the regulation of Sertoli cells in mice. J Steroid Biochem Mol Biol, 174, 133-140, 2017. DOI: 10.1016/j.jsbmb.2017.08.011

Ruijter JM1, Ramakers C, Hoogaars WM, Karlen Y, Bakker O, van den Hof MJ, Moorman AF: Amplification efficiency: Linking baseline and bias in the analysis of quantitative PCR data. Nucleic Acids Res, 37 (6): e45, 2009. DOI: 10.1093/nar/gkp045

Dorak M: Real Time PCR. Taylor & Francis, Oxford, UK, 2006.

Surai PF: Polyphenol compounds in the chicken/animal diet: From the past to the future. J Anim Physiol Anim Nutr, 98 (1): 19-31, 2014. DOI: 10.1111/jpn.12070

Belge C, Massion PB, Pelat M, Balligand JL: Nitric oxide and the heart: Update on new paradigms. Ann N Y Acad Sci, 1047 (1): 173-182, 2005. DOI: 10.1196/annals.1341.016

Hassanpour H, Yazdani A, Khabir Soreshjani K, Asgharzadeh S: Evaluation of endothelial and inducible nitric oxide synthase genes expression in the heart of broiler chickens with experimental pulmonary hypertension. Br Poult Sci, 50 (6): 725-732, 2009. DOI: 10.1080/ 00071660903141005

Munshi-South J, Wilkinson GS: Bats and birds: Exceptional longevity despite high metabolic rates. Ageing Res Rev, 9 (1): 12-19, 2010. DOI: 10.1016/j.arr.2009.07.006

Sohal RS, Weindruch R: Oxidative stress, caloric restriction, and aging. Science, 273 (5271): 59-63, 1996. DOI: 10.1126/science.273.5271.59

Nagy KA: Field metabolic rate and body size. J Exp Biol, 208: 1621- 1625, 2005. DOI: 10.1242/jeb.01553

Braun EJ, Sweazea KL: Glucose regulation in birds. Comp Biochem Physiol B Biochem Mol Biol, 151 (1): 1-9, 2008. DOI: 10.1016/j.cbpb. 2008.05.007

Jorge VG, Angel JR, Adrian TS, Francisco AC, Anuar SG, Samuel ES, Angel SO, Emmanuel HN: Vasorelaxant activity of extracts obtained from Apium graveolens: possible source for vasorelaxant molecules isolation with potential antihypertensive effct. Asian Pac J Trop Biomed, 3 (10): 776-779, 2013. DOI: 10.1016/s2221-1691(13)60154-9

Barros L, Carvalho AM, Ferreira ICFR: Comparing the composition and bioactivity of Crataegus Monogyna flwers and fruits used in folk medicine. Phytochem Anal, 22 (2): 181-188, 2011. DOI: 10.1002/pca.1267

Liu J: Pharmacology of oleanolic acid and ursolic acid. J Ethnopharmacol, 49 (2): 57-68, 1995. DOI: 10.1016/0378-8741(95)90032-2

Sajjadi SE, Shokoohinia Y, Moayedi NS: Isolation and identifiation of ferulic acid from aerial parts of Kelussia odoratissima Mozaff Jundishapur J Nat Pharm Prod, 7 (4): 159-162, 2012.

Mills S, Bone K: Principles and practice of phytotherapy. Modern Herbal Medicine. Churchill Livingstone, 2000.

Özcan M, Hacıseferoğulları H, Marakoğlu T, Arslan D: Hawthorn (Crataegus spp.) fruit: Some physical and chemical properties. J Food Eng, 69 (4): 409-413, 2005. DOI: 10.1016/j.jfoodeng.2004.08.032

Zulkifli I, Che Norma MT, Chong CH, Loh TC: Heterophil to lymphocyte ratio and tonic immobility reactions to preslaughter handling in broiler chickens treated with ascorbic acid. Poult Sci, 79 (3): 402-406, 2000. DOI: 10.1093/ps/79.3.402

Rajendran S, Deepalakshmi PD, Parasakthy K, Devaraj H, Devaraj SN: Effct of tincture of Crataegus on the LDL-receptor activity of hepatic plasma membrane of rats fed an atherogenic diet. Atherosclerosis, 123 (1- 2): 235-241, 1996.

Zhang Z, Ho WKK, Huang Y, James AE, Lam LW, Chen ZY: Hawthorn fruit is hypolipidemic in rabbits fed a high cholesterol diet. J Nutr, 132 (1): 5-10, 2002. DOI: 10.1093/JN/132.1.5

Long SR, Carey RA, Crofoot KM, Proteau PJ, Filtz TM: Effct of hawthorn (Crataegus oxycantha) crude extract and chromatographic fractions on multiple activities in a cultured cardiomyocyte assay. Phytomedicine, 13 (9-10): 643-650, 2006. DOI: 10.1016/J.PHYMED.2006.01.005

Chen JJ, Li XR: Hypolipidemic effct of flvonoids from mulberry leaves in triton WR-1339 induced hyperlipidemic mice. Asia Pac J Clin Nutr, 16 (Suppl. 1): 290-294, 2007.

Kouba M, Catheline D, Leclercq B: Lipogenesis in turkeys and chickens: A study of body composition and liver lipogenic enzyme activities. Br Poult Sci, 33 (5): 1003-1014, 1992. DOI: 10.1080/00071669208417543

Chu Y, Iida S, Lund DD, Weiss RM, DiBona GF, Watanabe Y, Faraci FM, Heistad DD: Gene transfer of extracellular superoxide dismutase reduces arterial pressure in spontaneously hypertensive rats. Circ Res, 92 (4): 461-468, 2003. DOI: 10.1161/01.RES.0000057755.02845.F9

Brixius K, Willms S, Napp A, Tossios P, Ladage D, Bloch W, Mehlhorn U, Schwinger RHG: Crataegus special extract WS® 1442 induces an endothelium-dependent, NO-mediated vasorelaxation via eNOSphosphorylation at serine 1177. Cardiovasc Drugs Ther, 20 (3): 177-184, 2006. DOI: 10.1007/s10557-006-8723-7

Lu Q, Qiu TQ, Yang H: Ligustilide inhibits vascular smooth muscle cells proliferation. Eur J Pharmacol, 542 (1-3): 136-140, 2006. DOI: 10.1016/j. ejphar.2006.04.023

Mladěnka P, Zatloukalová L, Filipský T, Hrdina R: Cardiovascular effects of flavonoids are not caused only by direct antioxidant activity. Free Radic Biol Med, 49 (6): 963-975, 2010. DOI: 10.1016/j.freeradbiomed. 2010.06.010
Kafkas Üniversitesi Veteriner Fakültesi Dergisi-Cover
  • ISSN: 1300-6045
  • Yayın Aralığı: Yılda 6 Sayı
  • Başlangıç: 1995
  • Yayıncı: Kafkas Üniv. Veteriner Fak.
Sayıdaki Diğer Makaleler

Polymorphisms of MBL Gene Introns and Their Association with MBL Serum Levels in Hu Sheep

Mengtig ZHAI, Jian MOU, Mengtig ZHU, Yanping LIANG, Mingyuan WANG, ? Zongsheng 1 ZHAO, Hongmei ZHANG

The Effct of Hot-Iron Disbudding on Thiol-Disulphide Homeostasis in Calves

Hasan ERDOĞAN, İlker ÇAMKERTEN, Güzin ÇAMKERTEN, Kerem URAL, SONGÜL ERDOĞAN, İsmail GÜNAL, Özcan EREL

Köpek ve Kedilerden Thermofilik Campylobacter İzolasyonu ve Moleküler Karakterizasyonu

Özkan ASLANTAŞ

Immunohistochemical Distribution of Somatostatin in Gastric Tissue of Diabetic Rats Treated with Cinnamon Extract

SEVDA ELİŞ YILDIZ, BUKET BAKIR, Şükran YEDİEL ARAS, SERPİL DAĞ, EBRU KARADAĞ SARI

Tarçın Ekstraktı İle Tedavi Edilen Diyabetik Sıçanların Mide Dokusunda Somatostatinin İmmunohistokimyasal Dağılımı

Buket BAKIR, Ebru KARADAĞ SARI, Sevda ELİŞ YILDIZ, Şükran YEDİEL ARAS, Serpil DAĞ

entamisinin İndüklediği Nefrotoksisitede Ozonun Koruyucu Etkisi ve Neutrophil Gelatinase-Associated Lipocalin (NGAL) Düzeyleri: Deneysel Çalışma

Sefer ÜSTEBAY, Ömer ERTEKİN, Döndü Ülker ÜSTEBAY, Yasemen ADALI, Ömür ÖZTÜRK

Establishment and Application of a Real-time, Duplex PCR Method for Simultaneous Detection of Mycoplasma hyopneumoniae and Mycoplasma hyorhinis

Yuzi WU, Hassan Z. A. ISHAG, Lizhong HUA, Lei ZHANG, Beibei LIU, Zhenzhen ZHANG, Haiyan WANG, Yanna WEI, Zhixin FENG, Hafizah Yousuf CHENIA, Guoqing SHAO, Qiyan XIONG

Evaluation of Intramammary Platelet Concentrate Efficacy as a Subclinical Mastitis Treatment in Dairy Cows Based on Somatic Cell Count and Milk Amyloid A Levels

GAMZE EVKURAN DAL, AHMET SABUNCU, SİNEM ÖZLEM ENGİNLER, Ali Can ÇETİN, BARAN ÇELİK, ÖMÜR KOÇAK

Mycoplasma hyopneumoniae ve Mycoplasma hyorhinis’in Aynı Anda Tespitinde Gerçek Zamanlı, Dubleks PCR Metodunun Uygulanması

Qiyan XIONG, Hassan Z. A. ISHAG, Zhixin FENG, Lizhong HUA, Beibei LIU, Zhenzhen ZHANG, Hafizah Yousuf CHENIA, Lei ZHANG, Haiyan WANG, Guoqing SHAO, Yuzi WU, Yanna WEI

Farklı Kürleme İşlemleri İle Üretilen Pastırmada Laktik Asit Bakterilerinin Genotipik İdentifikasyonu

Kübra ÇINAR, Güzin KABAN, Kübra FETTAHOĞLU