Özgür AKSOY, Oğuz MERHAN, Cihan KAÇAR, Semra KAYA, Rukiye TÜRK, İsa Özaydın, Ürfettin HÜSEYİNOĞLU, İlksen DÖNMEZ, Uğur AYDIN, Sadık YAYLA, Celal Şahin ERMUTLU

Genel Anestezi Altındaki Gebe Tavşanlarda Rocuronium ve Sugammadex’in Progesteron Düzeyine Etkisi

Sunulan çalışmada, genel anestezi uygulanan gebe tavşanlarda, rocuronium ve sugammadex uygulamasının progesteron düzeyine etkisinin saptanması amaçlandı. Çalışmada, 21 adet gebe Yeni Zelanda tavşanı kullanıldı. Her grupta 7 tavşan olacak şekilde üç gruba ayrıldı (Kontrol, Grup I, Grup II). Gebeliğin 21. gününde bulunan tüm tavşanlara 0.5 mg/kg midazolam ve 6 mg/kg propofol verildi. Daha sonra Sevofluran ile genel anesteziye alındı. Kontrol (C; n=7) grubundaki tavşanlar ise yalnızca genel anesteziye alındı. Grup I’deki tavşanlara genel anestezi başladığında roküronyum verildi. Grup II’de yer alan tavşanlara ise, genel anestezi ve rocuronium uygulamasından 60 dk sonra sugammadex verildi. Tüm tavşanlar genel anestezi süresince monitorize edildi. Tüm tavşanlardan venöz kan örneği alındı ve biyokimyasal olarak progesteron düzeyi analiz edildi. Rocuronium uygulamasının serum progesteron düzeyini tüm kaydedilen dakikalarda artışa neden olduğu belirlendi. Sugammadex uygulamasının ise, progesteron düzeyinde sayısal bir azalmaya neden olduğu belirlendi. Sonuç olarak, genel anesteziye alınan gebe tavşanlarda, rocuronium ve sugammadex uygulamasının progesteron düzeyi üzerine olumsuz bir etkisinin olmadığı saptandı.

The Effect of Rocuronium and Sugammadex on Progesterone Levels in Pregnant Rabbits Under General Anesthesia

The purpose of this study was to investigate the effect of rocuronium and sugammadex on progesterone (P4) levels in pregnant rabbitsunder general anesthesia. Twenty-one pregnant New Zealand rabbits were used in the study. After the rabbits were divided into threegroups of three (Control, Group I and Group II), each animal was given 0.5 mg/kg midazolam and 6 mg/kg propofol and then put undergeneral anesthesia with sevoflurane on the 21st day of pregnancy. No procedure was performed on the control group apart from anesthesia.Rocuronium was administered to GI at the onset of anesthesia, and in GII, sugammadex was administered 60 min after general anesthesia+ rocuronium. All of the rabbits were monitored during the anesthesia procedure. A sample of venous blood was taken and biochemicallyanalyzed to test P4 levels. The administration of rocuronium was determined to have caused an increase in the serum progesterone level inall recorded min. Sugammadex was found to cause a quantitative decrease in the level of progesterone. In conclusion, it was found out thatrocuronium and sugammadex administration did not have a negative effect on progesterone levels in pregnant rabbits receiving generalanesthesia.

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