SEVDA ELİŞ YILDIZ, FUNDA YİĞİT, Berna AYDIN DUMAN, EBRU KARADAĞ SARI, TURGAY DEPREM, SERAP KORAL TAŞÇI

Effects of kefir, koumiss, milk and yoghurt administration on distribution of plasma cells and mast cells in mice spleen

Bu çalışma, kefir, kımız, süt ve yoğurt uygulamasının fare dalak dokusunda, karşılaştıkları antijene spesifik antikor sentezleyen plazma hücreleri ile humoral ve hücresel olayların düzenlemesinde rolü olan mast hücrelerinin sayısal dağılımını belirlenmeyi amaçlanmıştır. Fareler (n=30) her grupta 6 adet olacak şekilde 5 gruba ayrıldı. İstatiksel değerlendirmeler sonucunda kefir, kımız, süt ve yoğurt grubunda bulunan farelerin canlı ağırlıklarının kontrol grubuna göre arttığı tespit edildi. Kefir, kımız, süt ve yoğurt uygulanan farelerin sterelojik yöntemle dalaktaki plazma hücreleri sayısına bakıldığında 15. günün sonunda kefir uygulanan farelerin dalağında plazma hücrelerinin sayısında diğer gruplara göre anlamlı bir artışın olduğu tespit edildi. 15. günün sonunda süt uygulanan farelerin dalağında mast hücrelerinin sayısında kontrol grubuna göre anlamlı bir artışın olduğu belirlendi. Yararlı mikroorganizmalardan oluşan kefirin, dalaktaki plazma hücre sayısına bakıldığında kımız, süt ve yoğurttan daha yüksek düzeyde bulunması; ayrıca süt uygulanan farelerin dalağında mast hücrelerinin sayısında kontrol grubuna göre anlamlı bir farkın olması sağlıklı beslenme/fonksiyonel gıda kapsamında dikkat çekicidir.

Kefir, kımız, süt ve yoğurt uygulamasının fare dalağında plazma hücresi ve mast hücrelerinin dağılımı üzerine etkileri

The present study was conducted to investigate the effect of kefir, koumiss, milk and yoghurt administration on plasma cells, which synthesize specific antibodies against antigens, and mast cells, which have a role in the regulation of humoral and cellular events, in the mice spleen tissues. Mice (n=30) were divided into 5 groups. As a result of statistical evaluation, live weights of mice in kefir, koumiss, milk and yoghurt groups were found to be increased compared to the control group. When numbers of plasma cells in spleens of mice treated with kefir, koumiss, milk and yoghurt were checked with stereological methods, significant diference was found to be increased in number of plasma cells of kefir-treated mice compared to other groups at the end of 15 days. At the end of day 15, a significant diference was found to be increased in the number of mast cells in the spleen of milk-treated mice compared to control group. As the number of plasma cells in the spleen is at higher level with kefir, than with koumiss, milk and yoghurt; also there being a significant diference between the numbers of mast cells in the spleens of mice treated with milk compared to control group, this is remarkable for healthy eating/functional food.

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