OSMAN KUTSAL, HAMİT KAAN MÜŞTAK, İnci Başak KAYA, GÖZDE YÜCEL TENEKECİ, Tuncer KUTLU

Concomitant Mammary Tuberculosis and Malignant Mixed Tumor in a Dog

Tüberküloz ve tümörler hem insanlarda hem de hayvanlarda gözlenen önemli birer sağlık problemi olup bu iki hastalık arasındaki ilişki hakkında halen çok soru işaretleri mevcuttur. Bu olguda 8 yaşlı, dişi, terrier bir köpekte malign miks tümör ve prodüktif tüberkülozün birlikte seyrettiği gözlendi. Klinikte operasyonla alınan sol meme zinciri patolojik yönden incelenmesi için getirildi. Histopatolojik inceleme için doku %10'luk tamponlu formalin solüsyonunda tespit edildi. Rutin doku takibinin ardından hazırlanan parafin bloklardan kesitler alınarak hematoksilen eozin ve asid fast tüberküloz basili tespiti için Ziehl- Neelsen boyamaları yapıldı. Mikroskobik incelemede atipik neoplazik bez epitel hücreleri ile merkezinde kazeifikasyon nekrozu bulunan tüberküllere rastlandı. Ayrıca Mycobacterium spp. PCR amplifikasyonu ile teyit edildi. Tüberküloz ve tümörün bir arada bulunması daha önce sadece bir keçide bildirilmiş olup evcil hayvanlarda nadir gözlenen bir olgudur

Bir Köpekte Memede Beraber Seyreden Tüberküloz ve Malign Mikst Tümör

Tuberculosis and tumors are two major health problems in both humans and animals; and there are still many question marks in the association between these two important diseases. In this case, malignant mixed tumor and productive tuberculosis were observed simultaneously in 8 years old, terrier, and female dog. After mastectomy of the left mammary chain; removed tissue was brought for pathological examination. For the histopathology examination, specimens were fixed in 10% neutral buffered formalin. Tissues were processed routinely and stained with hematoxylin-eosin and Ziehl-Neelsen for acid-fast bacilli detection. Microscopically, atypical neoplastic cells and caseation necrosis located in the center of tubercle were seen. After these findings, Mycobacterium spp. was investigated in the same sample and was confirmed by PCR amplification. Concomitant tuberculosis and neoplasm, previously reported in only a goat, is a rare occurrence in domestic animals

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