Clinical, Bacteriological, and Histopathological Aspects of Endotoxic Pyometra in Bitches

The object of this study was to compare the histopathologic change in uterus as well as the findings of clinical and bacteriological of twentyfour bitches with pyometra. Uterine lesions were grouped as acute endometritis, subacute endometritis, acute metritis, subacute metritis. Complete blood-count, blood biochemical parameters and toxin levels were determined. Only alkaline phosphatase levels were significantly different between all groups (P

Köpeklerde Endotoksik Pyometranın Klinik, Bakteriyolojik ve Histopatolojik Özellikleri

Bu çalışmanın amacı, pyometralı yirmi dört köpeğin uteruslarındaki histopatolojik değişikliklerin karşılaştırılmasıdır. Uterus lezyonları akut endometritis, subakut endometritis, akut metritis, subakut metritis olarak gruplandırıldı. Tam kan sayımı, kan biyokimyasal parametreler ve toksin seviyeleri belirlendi. Tüm gruplar arasındaki farklılık sadece alkalen fosfotaz seviyesinde önemliydi (P

___

Chatterjee I, Iredell JR, Woods M, Lipman J: The implications of enterococci for the intensive care unit. Crit Care Resusc, 9 (1): 69-75, 2007.

Sierig G, Cywes C, Wessels MR, Ashbaugh CD: Cytotoxic effects of streptolysin o and streptolysin s enhance the virulence of poorly encapsulated group a streptococci. Infect Immun, 71 (1): 446-455, 2003. DOI: 10.1128/IAI.71.1.446-455.2003

Spaulding AR, Salgado-Pabón W, Kohler PL, Horswill AR, Leung DYM, Schlieverta PM: Staphylococcal and streptococcal superantigen exotoxins. Clin Microbiol Rev, 26, 422-447, 2013. DOI: 10.1128/CMR.00104-12

Vehmas-Ali T, Sandholm M: Balance between bacteria and host - the bacteria’s point of view. In, Sandholm M, Honkanen-Buzalski T, Kaartinen L, Pyörälä S (Eds): The Bovine Udder and Mastitis, 49-58, Finland: Gummerus Kirjapaino Oy, Jyväskylä, 1995.

Toydemir Karabulut TSF, Inal Gültekin G, Ateş A, Turna Yilmaz Ö, Enginler SÖ, Kirşan I, Erdoğan Bamaç Ö, Arun SS, Demirtaş B: Effects of pyometra on some oxidative stress parameters, inflammatory mediators and neutrophil segmentation in bitches. Kafkas Univ Vet Fak Derg, 22, 837-846, 2016. DOI: 10.9775/kvfd.2016.15443

Wernicki A, Krzyzanowski J, Puchalski A: Characterization of Escherichia coli strains associated with canine pyometra. Pol J Vet Sci, 5, 51-56, 2002.

Hagman R, Kühn I: Escherichia coli strains isolated from the uterus and urinary bladder of bitches suffering from pyometra: Comparison by restriction enzyme digestion and pulsed-field gel electrophoresis. Vet Microbiol, 84, 143-153, 2002. DOI: 10.1016/S0378-1135(01)00449-7

Bigliardi E, Parmigiani E, Cavirani S, Luppi A, Bonati L, Corradi A: Ultrasonography and cystic hyperplasia-pyometra complex in the bitch. Reprod Domest Anim, 39, 136-140, 2004. DOI: 10.1111/j.1439- 0531.2004.00489.x

Demirel MA, Küplülü Ş: Investigation on the antiendotoxic effect of the combination of polymyxin E and ampicillin in dogs with endotoxic pyometra. Kafkas Univ Vet Fak Derg, 16, 313-318, 2010. DOI: 10.9775/ kvfd.2009.730

Heiene R, Kristiansen V, Teige J, Jansen JH: Renal histomorphology in dogs with pyometra and control dogs, and long term clinical outcome with respect to signs of kidney disease. Acta Vet Scand, 49: 13, 2007. DOI: 10.1186/1751-0147-49-13

Maddens B, Daminet S, Smets P, Meyer E: Escherichia coli pyometra induces transient glomerular and tubular dysfunction in dogs. J Vet Intern Med, 24, 1263-1270, 2010. DOI: 10.1111/j.1939-1676.2010.0603.x

Feldman EC, Nelson RW: Cystic endometrial hyperplasiapyometra complex. In, Feldman EC, Nelson RW (Eds): Canine and Feline Endocrinology and Reproduction, 852-866, W.B. Saunders Co, USA, 2004.

Chandra R, Villanueva E, Feketova E, Machiedo GW, Haskò G, Deitch EA, Spolarics Z: Endotoxemia down-regulates bone marrow lymphopoiesis but stimulates myelopoiesis: The effect of G6PD deficiency. J Leukoc Biol, 83, 1541-1550, 2008. DOI: 10.1189/jlb.1207838

Hagman R, Kindahl H, Lagerstedt AS: Pyometra in bitches induces elevated plasma endotoxin and prostaglandin F2α metabolite levels. Acta Vet Scand, 47 (1): 55-68, 2006. DOI: 10.1186/1751-0147-47-55

Jena B, Rao KS, Reddy KCS, Raghavender KBP: Comparative efficacy of various therapeutic protocols in the treatment of pyometra in bitches. Vet Med, 58 (5): 271-276, 2013

Fransson BA: Ovaries and uterus. In, Tobias KM, Johnston SA (Eds): Veterinary Surgery: Small Animal: 2-Volume Set. Urogenital System, Section XI, Chapter 109, 1871-1891, Saunders Elsevier, 2012

Bassessar V, Verma Y, Swamy M: Antibiogram of bacterial species isolated from canine pyometra. Vet World, 6 (8): 546-549, 2013. DOI: 10.5455/vetworld.2013.546-549

Voorwald FA, Marchi FA, Villacis RAR, Alves CEF, Toniollo GH, Amorim RL, Drigo SA, Rogatto SR: Molecular expression profile reveals potential biomarkers and therapeutic targets in canine endometrial lesions. PLoS One, 10 (7): e0133894, 2015. DOI: 10.1371/journal.pone. 0133894

Dovc P, Kunej T, Williams GA: Genetics and Genomics of Reproductive Disorders. In, Jiang Z, Ott TL (Eds): Reproductive Genomics in Domestic Animals, Chapter 4, 67-97, Wiley-Blackwell, USA, 2010

Ishiguro K, Baba E, Torii R, Tamada H, Kawate N, Hatoya S, Wijewardana V, Kumagai D, Sugiura K, Sawada T, Inaba T: Reduction of mucin-l gene expression associated with increased Escherichia coli adherence in the canine uterus in the early stage of dioestrus. Vet J, 173, 325-332, 2007. DOI: 10.1016/j.tvjl.2005.11.009

Kida K, Baba E, Torri R, Kawate N, Hatoya S, Wijewardana V, Sugiura K, Sawada T, Tamada H, Inaba T: Lactoferrin expression in the canine uterus during the estrous cycle and with pyometra. Theriogenology, 66, 1325-1333, 2006. DOI: 10.1016/j.theriogenology.2006.04.028

Coggan JA, Melville PA, Motos de Oliveira C, Faustino M, Moreno AM, Benites NR: Microbiological and histopathological aspects of canine pyometra. Braz J Microbiol, 39 (3): 477-483, 2008. DOI: 10.1590/S1517- 83822008000300012

Arora A, Sandford J, Browning GF, Sandy JR, Wright PJ: A model for cystic endometrial hyperplasia/pyometra complex in the bitch. Theriogenology, 66, 1530-1536, 2006. DOI: 10.1016/j.theriogenology. 2006.02.019

Siqueira AK, Ribeiro MG, Leite D da S, Tiba MR, de Moura C, Lopes MD, Prestes NC, Salerno T, da Silva AV: Virulence factors in Escherichia coli strains isolated from urinary tract infection and pyometra cases and from feces of healthy dogs. Res Vet Sci, 86 (2): 206-210, 2009. DOI: 10.1016/j.rvsc.2008.07.018

Radwińska J, Domosławska A, Pomianowski A, Żarczyńska K, Jurczak A: Implications of blood coagulation and fibrinolytic disorders in severe endometritis-pyometra complex in bitches. Bull Vet Inst Pulawy, 56, 293-297, 2012. DOI: 10.2478/v10213-012-0053-x

Tanja P, Barbara C, Kristina D, Pečar J, Alenka N, Butinar J: Haemostasis impairment in bitches with pyometra. Acta Vet-Beograd, 56: (5-6), 529-540, 2006. DOI: 10.2298/AVB0606529P

Smith FO: Canine pyometra. Theriogenology, 66, 610-612, 2006. DOI: 10.1016/j.theriogenology.2006.04.023

De Bosschere H, Ducatelle R, Vermeirsch H, Simoens, P, Coryn M: Estrogen-alpha and progesterone receptor expression in cystic endometrial hyperplasia and pyometra in the bitch. Anim Reprod Sci, 70, 251-259, 2002. DOI: 10.1016/S0378-4320(02)00013-1

Bartel C, Tichy A, Schoenkypl S, Aurich C, Walter I: Effects of steroid hormones on differentiated glandular epithelial and stromal cells in a three dimensional cell culture model of the canine endometrium. BMC Vet Res, 9:86, 2013. DOI: 10.1186/1746-6148-9-86

Ambrósio CE, Brolio MP, Martins DS, Morini JC, Carvalho AF, Miglino MA: Endometrial alterations, early placentation and maternal fetal interaction in carnivores. Rev Bras Reprod Anim, 35 (2): 217-228, 2011

Hagman R, Kindahl H, Fransson BA, Bergström A, Ström Holst B, Lagerstedt AS: Differentiation between pyometra and cystic endometrial hyperplasia/mucometra in bitches by prostaglandin F2α metabolite analysis. Theriogenology, 66, 198-206, 2006. DOI: 10.1016/j. theriogenology.2005.11.002

Van Cruchten S, Van den Broeck W, Simoens P, Lauwers H: Scanning electron microscopic changes of the canine uterine luminal surface during oestrus and late metoestrus. Reprod Domest Anim, 37 (3):121-126, 2002. DOI: 10.1046/j.1439-0531.2002.00347.x

Bronwyn Crane M: Pyometra. In, Silverstein D, Hopper K (Eds): Small Animal Critical Care Medicine Part XIII: Urogenital Disorders Chapter 126, 2nd edn., 667-671, Saunders Elsevier, 2015.

Sant’Anna MC, Giordano LGP, Flaiban KKMC, Muller EE, Martins MIM: Prognostic markers of canine pyometra. Arq Bras Med Vet Zootec, 66 (6): 1711-1717, 2014. DOI: 10.1590/1678-6859

Gibson A, Dean R, Yates D, Stavisky J: A retrospective study of pyometra at five RSPCA hospitals in the UK: 1728 cases from 2006 to 2011. Vet Rec, 173, 396, 2013. DOI: 10.1136/vr.101514

Jitpean S, Ström-Holst B, Emanuelson U, Höglund O, Pettersson A, Alneryd-Bull C, Hagman R: Outcome of pyometra in female dogs and predictors of peritonitis and prolonged postoperative hospitalization in surgically treated cases. BMC Vet Res, 10: 6, 2014. DOI: 10.1186/ 1746-6148-10-6

8. Jena B, Sadasiva Rao K, Reddy KCS, Raghavend KBP: Physiological and haematological parameters of bitches affected with pyometra. Vet World, 6 (7): 409-412, 2013. DOI: 10.5455/vetworld.2013.409-412

Küplülü S, Vural MR, Demirel A, Polat M, Akcay A: The comparative evaluation of serum biochemical, haematological, bacteriological and clinical findings of dead and recovered bitches with pyometra in the postoperative process. Acta Vet-Beograd, 59 (2-3): 193-204, 2009. DOI: 10.2298/AVB0903193K

6. Ramachandran G: Gram-positive and gram-negative bacterial toxins in sepsis. Virulence, 5, 213-218, 2014. DOI: 10.4161/viru.27024

5. Sykes JE: Gram negative bacterial infections. In, Sykes JE (Ed): Canine and Feline Infectious Diseases. Part II Major infectious diseases and their etiologic agents. Section 2 Bacterial diseases, 355-364, Saunders Elsevier, 2013.

Kempisty B, Bukowska D, Wozna M, Piotrowska H, Jackowska M, Zuraw A, Ciesiolka S, Antosik P, Maryniak H, Ociepa E, Porowski Sz, Brussow KP, Jaskowski JM, Nowicki M: Endometritis and pyometra in bitches: A review. Vet Med, 58 (6): 289-297, 2013

Karlsson I, Hagman R, Guo Y, Humblot P, Wang L, Wernersson S: Pathogenic Escherichia coli and lipopolysaccharide enhance the expression of IL-8, CXCL5, and CXCL10 in canine endometrial stromal cells. Theriogenology, 84, 34-42, 2015. DOI: 10.1016/j.theriogenology. 2015.02.008

Uçmak M, Tek Ç, Gündüz MC, Sabuncu A, Şenünver A, Bağcigil FA, Bakırel T: Optimum timing for operation in bitches with pyometra related to endotoxemia. Turk J Vet Anim Sci, 36 (1): 35-42, 2012. DOI: 10.3906/vet-1102-762

Baithalu RK, Maharana BR, Mishra C, Sarangi L, Samal L: Canine pyometra. Vet World, 3 (7): 340-342, 2010
Kafkas Üniversitesi Veteriner Fakültesi Dergisi-Cover
  • ISSN: 1300-6045
  • Yayın Aralığı: Yılda 6 Sayı
  • Başlangıç: 1995
  • Yayıncı: Kafkas Üniv. Veteriner Fak.
Sayıdaki Diğer Makaleler

Evaluation of Se, Cr and Zn-enriched Yeast Culture in Improving in vitro Fermentation Characteristics of Cereal Straws

Liang CHEN, Bin LI, Ao REN, Zhiwei KONG, Zhiliang TAN, Mahmoud ALAGAWANY, Mohamed Ezzat Abd EL-HACK, Chuanshe ZHOU

Çiğ Tavuk Etlerinden İzole Edilen Termofilik Campylobacter İzolatlarının Prevalansı ve Antimikrobiyal Direnci

Mehmet Cemal ADIGUZEL, Gülay Merve BAYRAKAL, Esra AKKAYA, Ahmet KOLUMAN, Tolga KAHRAMAN, Beren BAŞARAN KAHRAMAN, Ghassan ISSA, Funda YILMAZ EKER

Bimanual Capsulorhexis Using a New Hand Tool: An Experimental Study in Sheep Eye

Koray KARADAYI, Çağrı GÜLTEKİN, Ersin AYTAÇ

Birinci (1927) ve İkinci (1929) Balkan Veteriner Bulaşıcı Hayvan Hastalıkları Kongreleri Üzerine Tarihsel Bir İnceleme

Mehmet Yavuz ERLER, Ayşe Menteş GÜRLER, Şule SANAL

The Influence of Carcass Microlocation on the Speed of Postmortem Changes and Carcass Decomposition

Zdravko TOMIĆ, Nenad STOJANAC, Marko R. CINCOVIĆ, Nikolina NOVAKOV, Zorana KOVACEVIC, Ognjen STEVANCEVIC, Jelena ALEKSIĆ

Tavuk Karkaslarından İzole Edilen Salmonella spp. ve Listeria monocytogenes Prevalansı, Antimikrobiyal Direnci ve Moleküler Karakterizasyonu

Tolga KAHRAMAN, Beren BAŞARAN KAHRAMAN, Ghassan ISSA

Evaluation of Dietary Synbiotic Supplementation on Growth Performance, Muscle Antioxidant Ability and Mineral Accumulations, and Meat Quality in Late-finishing Pigs

Ye Fei CHENG, Yue Ping CHEN, Ming Fang DU, Chao WEN, Yan Min ZHOU

Effect of Different Dietary Lysine Regimens on Meat Quality Attributes in Varieties of Indigenous Aseel Chicken

Tahira BATOOL, Salman FAROOQ, Nabila ROOHI, Athar MAHMUD, Muhammad USMAN, Abdul GHAYAS, Sohail AHMAD

Farklı Probiyotik Kültür ve Ambalaj Malzemesiyle Üretilen Erzincan Tulum Peynirlerinin Bazı Özelliklerinin İncelenmesi

Oktay TOMAR, Gökhan AKARCA, Abdullah ÇAĞLAR, Mehmet BEYKAYA

Erdebil Bölgesinde Farklı Ölçeklerde Süt Üretimi Olan Geleneksel ve Endüstriyel Hayvancılık İşletmelirindeki Risk Faktörlerinin Ekonomik Değerlendirmesi

Azadeh BOUSTAN, Mohammad GHADIMI, Hossein ABDI BENAMAR, Reza SEYEDSHARIFI, Nemat HEDAYAT EVRIGH, Jamal SEIFDAVATI